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961 (0,124s) •

Project

Materials with nanostructured surface for biomedical applications (GA16-02702S)

peptides. Nano-pattern of ligands will be created by photocatalyzed CuAAC-based analogous ligands for cell receptors (integrins), with adequate molecular structure procedures that would allow the material surface to be mod...

CD - Makromolekulární chemie

  • 2016 - 2018
    • •
  • 6 111 tis. Kč
    • •
  • 5 574 tis. Kč
    • •
  • GA ČR
Project

Selection of diagnostic markers of the long-term effect of multifunctional peptide agonists and antagonists targeting µ-, δ- and κ-opioid receptors – search for new possibilities for treatment (LTAUSA18110)

The aim of this project is to test the effect of multifunctional peptides will be exposed or un-exposed to these multifunctional peptides for prolonged period of time by a given peptide. In parallel with these experiments, ...

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 4 982 tis. Kč
    • •
  • 4 982 tis. Kč
    • •
  • MŠMT
Project

Fundamental Principles of Protein Folding and Protein-Ligand Interactions Revealed by High-Level Quantum Chemical Calculations (GA20-08772S)

in protein structure, design, and protein-ligand interactions. Specifically, we will map and study the so-called protein frustration (strain) of the peptide fragments within the context of the protein. We will compare computed valu...

Physical chemistry

  • 2020 - 2022
    • •
  • 8 433 tis. Kč
    • •
  • 6 555 tis. Kč
    • •
  • GA ČR
Project

Research of Therapeutic Radiopharmaceuticals Based on Labeled Peptides with 177Lu (7AMB14AR009)

Joint research of targeted therapeutic radiopharmaceuticals based on bombesine and minigastrine derivetives labelled with therapeutic Lu-177 beta emitter. Development of methods for peptides derivatives conjugation and purification methods, ...

CH - Jaderná a kvantová chemie, fotochemie

  • 2014 - 2015
    • •
  • 148 tis. Kč
    • •
  • 148 tis. Kč
    • •
  • MŠMT
Project

Application of combinatorial libraries of affinity carriers for the identificatio of new interactions of the protein-ligand type (IAB4055003)

a variety of proteins and ligands. The principe of the method is based on the interaction of mixtures of immobilized ligands (arrays of affinity carriers of sublibraries) should lead to the identification of the unique ligand

CE - Biochemie

  • 2000 - 2002
    • •
  • 2 242 tis. Kč
    • •
  • 1 384 tis. Kč
    • •
  • AV ČR
Project

Preparation of surface nanoclusters of integrin ligands for control of cell adhesion (GPP207/10/P569)

of peptide-derived integrin ligands using spherical nanoparticles assembled from amphiphilic diblock copolymers. Ligands will be conjugated on the nanoparticles to create through the presentation of ligands of int...

CD - Makromolekulární chemie

  • 2010 - 2014
    • •
  • 1 008 tis. Kč
    • •
  • 1 008 tis. Kč
    • •
  • GA ČR
Project

Protein-protein interactions from molecular simulations (7AMB15AT029)

of theinteraction between the 14-3-3 protein and various phosphorylated peptides, studying the effect of local changes in the sequence on the affinity of the peptides to allowfor an accurate description of protein-peptide ...

CF - Fyzikální chemie a teoretická chemie

  • 2015 - 2016
    • •
  • 160 tis. Kč
    • •
  • 160 tis. Kč
    • •
  • MŠMT
Project

Affinity capillary electromigration methods for selective nanoanalysis of biomolecules and investigation of their interactions (GAP206/12/0453)

nanoanalysis of biomolecules (drugs, biomarkers, structural proteins, peptide/protein characterization of their interactions. New affinity ligands based on oligopyrrol macrocycles- and glyco-moieties of proteins/peptides o...

CB - Analytická chemie, separace

  • 2012 - 2014
    • •
  • 9 592 tis. Kč
    • •
  • 9 592 tis. Kč
    • •
  • GA ČR
Project

Synthesis of Ligands for Interactions with Tetrameric and Pentameric Proteins (GP14-24880P)

Proteins composed from symmetric units have an important role in biological systems, many of them control the core elements of life. This project deals with the preparation of ligands based on 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraace...

CC - Organická chemie

  • 2014 - 2016
    • •
  • 2 664 tis. Kč
    • •
  • 2 664 tis. Kč
    • •
  • GA ČR
Project

Affinity capillary electrophoresis and electrochromatography, their use for study of biomolecular interactions (GA203/06/1044)

for highlysensitive and highly selective analysis of biomolecules, such as drugs, peptide of these biomolecules with both low- and high-molecular mass ligands. New types of affinity ligands electrochromatography. New l...

CB - Analytická chemie, separace

  • 2006 - 2008
    • •
  • 2 850 tis. Kč
    • •
  • 2 850 tis. Kč
    • •
  • GA ČR
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