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9 927 (0,113s) •

Project

Fatty acid- and glucose-induced changes in gene expression of peroxisome proliferator-activated receptor (PPAR) signalling cascade molecules (OC 153)

investigation of effects of major energetic substrates on gene expression of major molecular components of signalling molecules...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2010
    • •
  • 2 910 tis. Kč
    • •
  • 1 895 tis. Kč
    • •
  • MŠMT
Project

Generation of high throughput in vitro models based on reporter gene assays for toxicological and environmental application (GA16-07544S)

easily gain entry to the food chain. The peroxisome proliferator-activated receptors (PPARs) and their heterodimeric partner retinoid X receptor alpha (RXR-alpha) are very often target of EDCs. <...

DN - Vliv životního prostředí na zdraví

  • 2016 - 2018
    • •
  • 4 691 tis. Kč
    • •
  • 4 691 tis. Kč
    • •
  • GA ČR
Project

Cardiovascular risk factors cluster analyzed by transgenesis of the peroxisome proliferatoractivated receptor gamma (GA301/01/0278)

The thiazolidinediones (TZD) belongs to a class of insulin-sensitizing, antidiabetic drugs which exert their effects through interactions with peroxisome proliferator-activated receptor gamma (PPARgamma). Although ...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 5 017 tis. Kč
    • •
  • 3 564 tis. Kč
    • •
  • GA ČR
Project

Influence of cadmium and mercury compounds and fish lipids on cell lipid metabolism, oxidative stress and cell viability (GA13-01543S)

on peroxisome proliferates activated receptors (PPARs) α, β and γ and the desaturases ∆-5...

GM - Potravinářství

  • 2013 - 2017
    • •
  • 5 190 tis. Kč
    • •
  • 5 190 tis. Kč
    • •
  • GA ČR
Project

The study of antitumor activity of synthetic ligands of PPARs on glioblastoma cell lines and on explants of glial tumors of brain (NR8370)

To find if selected synthetic ligands of PPARs (ciglitazone, etc.) affect growth and differentiation of cell explants of glial tumors. Analysis of effect of PPAR antagonists (Diclofenac, Nimesulid, MK 886, etc.) on proliferation...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 2 915 tis. Kč
    • •
  • 2 215 tis. Kč
    • •
  • MZ
Project

Study of the genetic background of the polycystic ovary syndrome (GA301/04/1085)

receptor, sex hormone binding globulin, insulin variable number of tandem repeats, insulin receptor, insulin receptor substrate 2, peroxisome proliferator activator......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 4 460 tis. Kč
    • •
  • 4 454 tis. Kč
    • •
  • GA ČR
Project

Complexes of selected transition metals with plant-derived compounds with anti-NF-kappa B and pro-PPAR dual activities (GF21-38204L)

problem.Promising approach to manage inflammatory processes is the modulation of activity of pro-inflammatory transcription factor NFκB and simultaneous activation of anti-inflammatory nuclear receptors PPAR. This...

Inorganic and nuclear chemistry

  • 2021 - 2023
    • •
  • 9 028 tis. Kč
    • •
  • 9 028 tis. Kč
    • •
  • GA ČR
Project

The role of peripheral metabolism of glucocorticoids in inflammation-induced changes in humans and animal model of inflammatory bowel disease (NR8576)

-up. Receptors of PPAR gama could modulate expression of 11HSDTissue concentration of steroid metabolites will be measured in experimental models of IBD activity of 11 HSD will be estimated in tisue homogenates.Expression m...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2005 - 2007
    • •
  • 3 732 tis. Kč
    • •
  • 3 607 tis. Kč
    • •
  • MZ
Project

Inhibition of metastatic spread via impact on components of plasminogen activator (KJB501070501)

. Consequently PPAR? receptors are activated and the activity of NF-kappa-B transcription. Through additive application of thiazolidinediones (agonists of PPAR? receptorsThe project is targeted on...

FD - Onkologie a hematologie

  • 2005 - 2007
    • •
  • 1 155 tis. Kč
    • •
  • 1 155 tis. Kč
    • •
  • AV ČR
Project

Biochemical and cellular markers of toxic and carcinogenic effects of xenobiotics (GA525/98/1266)

of changes in bioactivation processes, oxidative stress, peroxisomal proliferation and in parameters reflecting cell kinetics (cell cycle, proliferation, and apoptosis) of the project are: 1) to recognise possible changes ...

DN - Vliv životního prostředí na zdraví

  • 1998 - 2000
    • •
  • 3 328 tis. Kč
    • •
  • 2 827 tis. Kč
    • •
  • GA ČR
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