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Projects

43 projects (0,199s) •

Project

Translation Omics technologies into better understanding of Bordetella pertussis pathogenicity (NV16-30782A)

Bordetella pertussis is the causative agent of human whooping cough (pertussis-preventable infectious disease. Despite generalized vaccination, pertussis is again in pertussis cases has been mostly attributed to sh...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2016 - 2019
    • •
  • 10 854 tis. Kč
    • •
  • 10 611 tis. Kč
    • •
  • MZ
Project

Study and comparison of the Bordetella pertussis strains isolated during the period 1964-2015 by molecular biological methods and applications of the results as the basis for the draft update (NT14058)

B. pertussis isolates from 1964-2015 obtained from CR will be analysed set will include 190 isolates of B. pertussis. The data will be used for analysing with the whole-cell and later with acellular pertussis vaccines in th...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2013 - 2015
    • •
  • 4 330 tis. Kč
    • •
  • 4 330 tis. Kč
    • •
  • MZ
Project

Interactions of Bordetella pertussis virulence factors with host cells (GA19-12695S)

Bordetella pertussis causes the respiratory infectious disease called pertussis the adenylate cyclase toxin (CyaA), the pertussis toxin (PT) and the filamentous. pertussis virulence in vivo and on the role of diffe...

Microbiology

  • 2019 - 2021
    • •
  • 9 821 tis. Kč
    • •
  • 9 821 tis. Kč
    • •
  • GA ČR
Project

Interaction of the pertussis agent with ciliated epithelia of nasal mucosa (GX25-18104X)

Interactions of Bordetella pertussis with nasopharyngeal epithelium remain poorly understood. For long time it could not be studied how does the human pertussis infection in immunodeficient MyD88 KO mice, in which B. pertussis

Microbiology

  • 2025 - 2029
    • •
  • 50 000 tis. Kč
    • •
  • 50 000 tis. Kč
    • •
  • GA ČR
Project

Role of filamentous hemagglutinin in complement resistance of B. pertussis (GA24-10936S)

The Gram-negative respiratory pathogen Bordetella pertussis produces a surface. pertussis attachment to airway epithelium. FhaB was also proposed to exert data indicate that FhaB plays a critical role in B. pertussis evasio...

Infectious Diseases

  • 2024 - 2026
    • •
  • 12 462 tis. Kč
    • •
  • 12 462 tis. Kč
    • •
  • GA ČR
Project

Transcriptomics of Bordetella pertussis and human phagocytes interplay (GF16-34825L)

Bordetella pertussis is the causative agent of human whooping cough, a highly vaccinated populations. B. pertussis has been traditionally viewed as a typical, it was demonstrated that B. pertussis cells upon infection of...

EB - Genetika a molekulární biologie

  • 2016 - 2020
    • •
  • 6 942 tis. Kč
    • •
  • 6 942 tis. Kč
    • •
  • GA ČR
Project

Immunosuppressive action of the whooping cough agent and new vaccination tools for prevention of pertussis (NV16-28126A)

Pertussis or whooping cough is a life threatening infectious disease. This is largely due to use of safe but less efficient acellular pertussis vaccines that were developed without the understanding of mechanisms by which Bordetella...

EE - Mikrobiologie, virologie

  • 2016 - 2019
    • •
  • 9 920 tis. Kč
    • •
  • 9 920 tis. Kč
    • •
  • MZ
Project

The role of the non-coding RNome in the physiology and virulence of the human pathogen Bordetella pertussis (GA19-12338S)

Bordetella pertussis is a Gram-negative strictly human pathogen of the respiratory tract and the etiological agent of whooping cough (pertussis). This highly for virulence of B. pertussis and thereby suggested that riboregu...

Microbiology

  • 2019 - 2021
    • •
  • 8 758 tis. Kč
    • •
  • 8 758 tis. Kč
    • •
  • GA ČR
Project

Concerted toxin action in Bordetella pertussis virulence (GX19-27630X)

of its protein toxins, the whooping cough agent Bordetella pertussis compromises. A set of specifically mutated B. pertussis strains will be used for intranasal eliciting the initial pertussis phase coryza and enabling spr...

Microbiology

  • 2019 - 2023
    • •
  • 49 158 tis. Kč
    • •
  • 49 158 tis. Kč
    • •
  • GA ČR
Project

Actions of Bordetella pertussis effector protein BteA in respiratory epithelia (GA21-05466S)

by Bordetella pertussis and B. parapertussis. These pathogenic bacteria employ a type III in modulation of ciliated respiratory epithelia and in human pertussis. We hypothesize that BteA-induced modulation of respiratory epithelia ...

Cell biology

  • 2021 - 2023
    • •
  • 9 724 tis. Kč
    • •
  • 9 724 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 43