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111 (0,094s) •

Project

Targeted gene therapy for pharmacoresistant focal epilepsy (NU21-08-00533)

Pharmacoresistant epilepsy is a substantial global disease burden that has of patients with pharmacoresistant epilepsy remains unchanged. There is an urgent need is a suitable approach to tackle pharmacoresista...

Neurosciences (including psychophysiology)

  • 2021 - 2024
    • •
  • 11 568 tis. Kč
    • •
  • 11 568 tis. Kč
    • •
  • MZ
Project

Lesion detection in non-lesional epilepsies using multimodal imaging methods (NV17-32292A)

with pharmacoresistent epilepsy classified as non-lesional/lesional, resp., will be rescannedPrecise localisation of brain lesion is critical for the outcome of epilepsy surgery. The definition of non-lesional epilepsy...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2021
    • •
  • 14 206 tis. Kč
    • •
  • 12 846 tis. Kč
    • •
  • MZ
Project

Enhanced pre-surgical evaluation in drug-resistant epilepsy using machine/deep learning models (NU22-08-00278)

Surgical removal of the epileptogenic tissue or implantation of a stimulation device represents the best chance for patients with pharmacoresistant epilepsy to be seizure-free. Intracranial EEG acquisition, processing, and machine l...

Clinical neurology

  • 2022 - 2025
    • •
  • 7 865 tis. Kč
    • •
  • 7 865 tis. Kč
    • •
  • MZ
Project

The Optimization of methodics of analysis and evaluation of the simultaneous EEG-fMRI in patient with pharmacoresistant epilepsy (GAP304/11/1318)

for candidates to epilepsy surgery. The main objective of proposed project...

FH - Neurologie, neurochirurgie, neurovědy

  • 2011 - 2013
    • •
  • 6 359 tis. Kč
    • •
  • 6 359 tis. Kč
    • •
  • GA ČR
Project

Intracranial EEG signal processing; epileptogenic zone identification in non-lesional refractory epilepsy patients (NT11460)

One third of epilepsy patients are pharmacoresistent and epilepsy surgery is considered. The outcome in non-lesional cases remains unsatisfactory and one of the crucial steps is the ability to better identify the epileptoge...

FH - Neurologie, neurochirurgie, neurovědy

  • 2010 - 2013
    • •
  • 5 094 tis. Kč
    • •
  • 5 094 tis. Kč
    • •
  • MZ
Project

Detection of seizure onset zone in multi-lesional epilepsies using multimodal imaging methods (NU21-04-00254)

is therefore considered as a treatment option. Epilepsy surgery is the most efficient therapy for patients with pharmacoresistant epilepsy. In multi-lesional focal epilepsies (MLE) surgical resection is possible o...

Clinical neurology

  • 2021 - 2024
    • •
  • 11 819 tis. Kč
    • •
  • 11 819 tis. Kč
    • •
  • MZ
Project

Advancing MRI Protocol for Detecting Epileptogenic Tissue through Vascular Response Analysis during Hypercapnic Challenge - /MrEpiVaR/ (NW25-08-00371)

pharmacoresistant epilepsy. Accurate localization of these epileptogenic areas is essential. Consequently, its utilization is rather low. In 2023, at the Centre for Pharmacoresistant Epilepsies of Motol University...

Radiology, nuclear medicine and medical imaging

  • 2025 - 2028
    • •
  • 16 733 tis. Kč
    • •
  • 16 733 tis. Kč
    • •
  • MZ
Project

Hippocampal involvement in neocortical epilepsy networks Implications for surgical planning (NU21J-08-00081)

Epilepsy is a neurological disorder characterized by recurrent seizures. A subpopulation of patients with pharmacoresistant epilepsy can benefit from epilepsy surgery in last ten decades. Results of the epileps...

Clinical neurology

  • 2021 - 2024
    • •
  • 6 706 tis. Kč
    • •
  • 6 706 tis. Kč
    • •
  • MZ
Project

The role of neurodegeneration in pathogenesis, manifestations and prognosis of MTLE/HS - in vivo, ex vivo and in vitro perspective (NU22-04-00366)

Temporal lobe epilepsy as the most prevalent form of focal epilepsy poses of neurodegenerative pathways in epilepsy, mostly exploring neurodegeneration associated proteins isoforms and alpha-synuclein). Studies focusing on ...

Neurosciences (including psychophysiology)

  • 2022 - 2025
    • •
  • 10 693 tis. Kč
    • •
  • 10 693 tis. Kč
    • •
  • MZ
Project

Enhancing epilepsy treatment with temporal interference of electric fields and advanced computational strategies (NW25-04-00226)

Surgical removal of the epileptogenic tissue or implantation of a stimulation device represents the best chance for patients with pharmacoresistant epilepsy to be seizure-free. Novel cutting-edge technologies of deep brain stimulati...

Clinical neurology

  • 2025 - 2028
    • •
  • 7 773 tis. Kč
    • •
  • 7 773 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 111