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1 158 (0,254s) •

Project

The influence of X-inactivation on phenotype in comon X-linked metabolic disorder, its tissue distribution and inheritance (NR8361)

and similar assays. We will also study polymorphisms in Xist/TSIX. We will study tissue studies. We will study the relationship between X-inactivation and phenotype the X-inactivation studies can be used for prediction of pheno...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 3 901 tis. Kč
    • •
  • 3 869 tis. Kč
    • •
  • MZ
Project

System for searching for new biologically active compounds. Foccused combinatorial libraries. (FT-TA5/136)

IMG AS CR owns a unique technology for high-throughput screening for biological activity. RE&D VUFB company is experienced in medicinal chemistry and builds the technology for parallel synthesis combinatorial chemistry. In this co-operation IMG would...

CC - Organická chemie

  • 2008 - 2010
    • •
  • 11 224 tis. Kč
    • •
  • 7 127 tis. Kč
    • •
  • MPO
Project

Molecular characterisation of resistant mutants of viral protease from HIV-positive patients developed under the selection pressure of protease inhibitors design of novel inhibitors and diagnostics for individualised molecular medicine (NR8571)

The project involves analysis of resistance development in HIV-positive patients treated by protease inhibitors in the CR, design of novel, non-infectious phenotypic resistance assays and design of novel inhibitors, active against r...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2005 - 2007
    • •
  • 3 829 tis. Kč
    • •
  • 3 621 tis. Kč
    • •
  • MZ
Project

Human milk immune factors and their influence on atopic reactivity in breastfed infants with high risk of atopy (NI5206)

Human milk will be assayed for cytokine (IL-4, IFN- y, TGF - beta) and immunoglobuline pattern in a cohort of atopic and nonatopic lactating women. Human milk cell phenotype (CD4, CD8, CD 45RA/RO) will be determined with flow cytome...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1999 - 2001
    • •
  • 1 931 tis. Kč
    • •
  • 1 931 tis. Kč
    • •
  • MZ
Project

Regeneration initiation cells - a new player in healing and regeneration (GA24-12027S)

with functional assays and phenotype characterization. The results from this research...

Cell biology

  • 2024 - 2026
    • •
  • 8 984 tis. Kč
    • •
  • 8 901 tis. Kč
    • •
  • GA ČR
Project

Role of the ERK-RSK signaling module in the temporal control of epithelial-mesenchymal transition. (GA13-06405S)

phenotypic siRNA screen to identify proteins that function specifically downstream of ERK or RSK signaling during epithelial-mesenchymal transition. The phenotypic assays......

EB - Genetika a molekulární biologie

  • 2013 - 2017
    • •
  • 11 868 tis. Kč
    • •
  • 11 868 tis. Kč
    • •
  • GA ČR
Project

p53 gene mutations in patients with chronic lymphocytic leukemia and their biological and prognostical significance (NR9186)

not a priori mean a phenotype. Functional testing of p53 in patients with CLL employing in vitro assay FASAY allows to assess possible biological activity of p53 variants.......

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 4 533 tis. Kč
    • •
  • 4 349 tis. Kč
    • •
  • MZ
Project

Molecular DNA repair characteristics in CRC tumor tissue (GAP304/12/1585)

repair capacities reflect the actual cell phenotype of both hereditary and variable assay (both base and nucleotide excision repair) in the tumor tissue is conducted phenotypes.......

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 13 871 tis. Kč
    • •
  • 13 871 tis. Kč
    • •
  • GA ČR
Project

Investigation on the role of cholinergic neurotransmission in aging and pathogenesis of Alzheimer´s disease (IAA500110703)

physiological functional ex vivo experiments, ligand binding assays, and cholinergic protein activity assays. Changes in gene transcription and translation will be detected using......

ED - Fyziologie

  • 2007 - 2011
    • •
  • 7 060 tis. Kč
    • •
  • 7 060 tis. Kč
    • •
  • AV ČR
Project

A functional assay for heterozygous mutations in the GTPase activating protein related domain of the neurofibromatosis type 1 gene (NM7627)

to phenotype...

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 563 tis. Kč
    • •
  • 553 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 1 158