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2 307 (0,118s) •

Project

In-solution study of the lipid kinase PI4KB heteromeric protein complexes (GA17-05200S)

Large dynamic protein complexes cannot be studied by traditional protein crystallography due to their intrinsically disordered regions. Traditional NMR techniques are also not suitable due to their size. Phosphatidylinositol 4-kinas...

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 5 616 tis. Kč
    • •
  • 4 734 tis. Kč
    • •
  • GA ČR
Project

Good-Cop/Bad-Cop Distinct roles of anionic phospholipids in plant endocytosis (GA19-21758S)

higher content of phosphatidic acid (PA) and phosphatidylinositol 4-phosphate. In ourEndocytosis is crucial process in the establishment and maintenance of cell polarity. Minor anionic phospholipids are key regulators of c...

Cell biology

  • 2019 - 2022
    • •
  • 7 356 tis. Kč
    • •
  • 7 356 tis. Kč
    • •
  • GA ČR
Project

The role of phosphoinositides in Wnt signalling (GJ16-17966Y)

, we will study the role of phosphatidylinositol-4-phosphate 5-kinase (PIP5K...

EB - Genetika a molekulární biologie

  • 2016 - 2020
    • •
  • 6 795 tis. Kč
    • •
  • 6 795 tis. Kč
    • •
  • GA ČR
Project

Rational design of phosphatidylinositol 4-kinase IIalpha inhibitors as tools for chemical biology and potential therapeutics (GA15-09310S)

Phosphatidylinositol 4-kinase IIalpha (PI4KIIa) is an enzyme which belongs to the family of human lipid kinases and which participates on a number of physiological and pathological processes in cells. Among others, it seems to play ...

CC - Organická chemie

  • 2015 - 2017
    • •
  • 5 104 tis. Kč
    • •
  • 5 104 tis. Kč
    • •
  • GA ČR
Project

Bottom-up unraveling of biophysical determinants of ORP5/8 mediated lipid transport using in vitro reconstitution and model membranes (GA19-18917S)

in the control of phosphatidylserine and phosphatidylinositol 4-phosphate content in plasma...

Biochemistry and molecular biology

  • 2019 - 2021
    • •
  • 3 705 tis. Kč
    • •
  • 3 705 tis. Kč
    • •
  • GA ČR
Project

Phospholipid metabolizing enzymes as new components of salicylic acid signalling pathway (GA17-05151S)

that phosphatidylinositol-4-kinases β1 and β2 are negative regulators of SA biosynthesis. Additionally...

CE - Biochemie

  • 2017 - 2021
    • •
  • 10 465 tis. Kč
    • •
  • 9 874 tis. Kč
    • •
  • GA ČR
Project

Phospholipase D regulated transcriptome of systemic acquired resistence in Arabidopsis thaliana (ME 943)

willbe mostly identical with those regulated by phosphatidylinositol 4-kinase, the enzyme producing phosphatidylinositol 4,5-bisphospahate, an activator of PLD......

CE - Biochemie

  • 2007 - 2008
    • •
  • 381 tis. Kč
    • •
  • 381 tis. Kč
    • •
  • MŠMT
Project

Advanced correlated light and electron microscopy as a tool for studying novel nuclear structures and their impact on the gene transcription and global nuclear architecture (LTC19048)

interactions of functional molecules in the cell nucleus. 4. Characterization of NLI...

Cell biology

  • 2019 - 2022
    • •
  • 8 308 tis. Kč
    • •
  • 8 308 tis. Kč
    • •
  • MŠMT
Project

Metal Oxides and Phosphates as Nuclear Waste Forms Sonochemical Precipitation, Thermal Transformations, and Solubility Studies (GAP207/11/0555)

The central topic of the project is the study of sonochemical precipitation of binary and multimetallic oxides and phosphates from solutions of UO22+, metals, high-boiling hydrocarbons, and tributyl phosphate. We will develop the op...

CA - Anorganická chemie

  • 2011 - 2013
    • •
  • 6 842 tis. Kč
    • •
  • 6 842 tis. Kč
    • •
  • GA ČR
Project

Preparation and properties studies of scntillating phosphate glasses with increased efficiency (IAA2010304)

Recently we have developed an original concept of transferefficeincy increace based on the embedded energy-guiding sublattice of Gd3+ in the phosphate glass durability. Accordingly, preparation and characterisation of doped Na phosphate<...

BM - Fyzika pevných látek a magnetismus

  • 2003 - 2005
    • •
  • 3 391 tis. Kč
    • •
  • 2 038 tis. Kč
    • •
  • AV ČR
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