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6 034 (0,067s) •

Project

Novel readouts for the planar cell polarity (PCP) pathway (GA17-16680S)

pathways regulating polarity is the non-canonical Wnt/planar cell polarity (PCP) pathway, which mediates cytoskeletal changes underlying cell polarity and migration. Im...

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 7 020 tis. Kč
    • •
  • 6 801 tis. Kč
    • •
  • GA ČR
Project

Structural insights into the function of the key planar cell polarity regulator Vangl2 (GA25-17258S)

The Wnt/planar cell polarity (PCP) pathway is a non-canonical Wnt signaling branch, known for controlling the polarization and migration of cells. Wnt/PCP protein Vangl2. Vangl2 ...

Biochemistry and molecular biology

  • 2025 - 2027
    • •
  • 13 424 tis. Kč
    • •
  • 13 424 tis. Kč
    • •
  • GA ČR
Project

Structural biology of the Wnt/PCP signaling pathway (LUAUS25170)

The non-canonical Wnt pathway, specifically the planar cell polarity (PCP, tissue homeostasis, and cell migration. The PCP pathway controls cell polarity and

Biochemistry and molecular biology

  • 2025 - 2028
    • •
  • 11 980 tis. Kč
    • •
  • 11 980 tis. Kč
    • •
  • MŠMT
Project

Revealing the Mechanism of Neural Tube Formation (GA22-06405S)

of the apical cell surface. NT formation has been shown to involve planar cell polarity (PCP). PCP is a universal property of cells polarized in the plane of tissue, which is ma...

Developmental biology

  • 2022 - 2024
    • •
  • 6 444 tis. Kč
    • •
  • 6 444 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of non-canonical Wnt signaling in leukemia (GAP301/11/0747)

of non-canonical Wnt signalling (Wnt/PCP pathway) in context of B-Cell Chronic LymphocyticLeukaemia (CLL). Functional studies of the Wnt/PCP pathway in disease conditions by studying the role of the Wnt/<...

FD - Onkologie a hematologie

  • 2011 - 2014
    • •
  • 5 360 tis. Kč
    • •
  • 5 360 tis. Kč
    • •
  • GA ČR
Project

Analysis of WNT/PCP pathway for better management of chronic lymphocytic leukemia (NV15-29793A)

Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults in the Czech Republic. The recent data from our laboratories suggest that one of the crucial molecular pathways associated with pathogenesis of CLL is Wnt/PCP

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 9 937 tis. Kč
    • •
  • 9 937 tis. Kč
    • •
  • MZ
Project

The regulatory function of the ERK pathway in the spatial distribution of intracellular organelles. (GA204/09/0614)

of the earliest steps in cell migration process is the establishment of migration polarity cell motility by regulating the establishment of cell polarity. My preliminary data regulates the nuclear reposit...

EB - Genetika a molekulární biologie

  • 2009 - 2013
    • •
  • 7 072 tis. Kč
    • •
  • 7 072 tis. Kč
    • •
  • GA ČR
Project

The role of cytoskeleton and cell wall in the cell polarization (GA204/99/D025)

) in the process of the cell polarity will be studied on the model of budding yeast as processes changing cell polarity. Cdc mutants showing defect in the cell polarization glycerol pathway

EA - Morfologické obory a cytologie

  • 1999 - 2002
    • •
  • 740 tis. Kč
    • •
  • 540 tis. Kč
    • •
  • GA ČR
Project

The role of the exocyst complex in the plant-pathogen interaction (GAP501/10/2081)

, was extensively studied in yeast and mammals in relation to cell polarity. Recently we mutants exhibit defective cell polarity and growth. Cell polarization is a crucial factor for the efficient...

EF - Botanika

  • 2010 - 2012
    • •
  • 4 165 tis. Kč
    • •
  • 4 165 tis. Kč
    • •
  • GA ČR
Project

Touching the untouchable; biochemistry of full-length Vangl2 protein (8J25FR012)

The main gap we have identified in the WNT/PCP field is on mechanistic as a scaffold upon which the core pathway components as well as positive and negative regulators of the WNT/PCP signaling assemble. By applying state-of...

Biochemistry and molecular biology

  • 2025 - 2026
    • •
  • 200 tis. Kč
    • •
  • 200 tis. Kč
    • •
  • MŠMT
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