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4 881 (0,14s) •

Project

Sensing of hepatitis B virus-infected hepatocytes by plasmacytoid dendritic cells (GA17-15422S)

The role of plasmacytoid dendritic cells (pDCs), a major source of interferon (IFN) alpha in human organism, in pathogenesis of hepatitis B virus (HBV) infection is not clear. We hypothesize that pDCs could be involved via ...

EE - Mikrobiologie, virologie

  • 2017 - 2021
    • •
  • 7 608 tis. Kč
    • •
  • 6 891 tis. Kč
    • •
  • GA ČR
Project

Sensing of HIV-1 by plasmacytoid dendritic cells dichotomy of immunoreceptor signaling (GA14-32547S)

The role of plasmacytoid dendritic cells (pDCs), the major source of type I interferon (IFN-I) in human organism, in pathogenesis of HIV-1 infection is not clear. In contrast to HIV-1 infected lymphocytes, HIV-1 virions are...

EE - Mikrobiologie, virologie

  • 2014 - 2018
    • •
  • 6 397 tis. Kč
    • •
  • 6 397 tis. Kč
    • •
  • GA ČR
Project

Functional characteristics of circulating dendritic cells in patients with X-linked agammaglobulinemia (NS10489)

Study of homeostasis and function of peripheral blood dendritic cell subsets of antigen presenting cells, their capacity to recognize the presence of pathogen-derived thefunction of all identified Toll like receptors on mye...

EC - Imunologie

  • 2009 - 2011
    • •
  • 5 717 tis. Kč
    • •
  • 5 717 tis. Kč
    • •
  • MZ
Project

Phenotype and function of head and neck squamous cell carcinoma immune cells as predictive markers of clinical response (NV17-28055A)

cells and tumor-associated plasmacytoid dendritic cells (pDCs) will be studied. One squamous cell carcinoma ( HNSCC) to improve the predictivity of the clinical response and circulating cells of ...

FE - Ostatní obory vnitřního lékařství

  • 2017 - 2021
    • •
  • 13 556 tis. Kč
    • •
  • 13 098 tis. Kč
    • •
  • MZ
Project

Comparison of dendritic cells from healthy volunteers, patients with monoclonal gammopathy and multiple myeloma according to their functional properties (NR8081)

The aim of project is analysis of function state of dendritic cells generated volunteers. The aim of project is finding of possible defects of dendritic cells result inhibitors from seras can be used to regenerate ...

EC - Imunologie

  • 2004 - 2006
    • •
  • 1 367 tis. Kč
    • •
  • 1 315 tis. Kč
    • •
  • MZ
Project

Glycobiological characterization of head and neck tumors (GP304/03/P027)

Dendritic cells represent the most potent antigen-presenting cells in the human reaction. The expression of dendritic cells in normal human squamous epithelia of dendritic cells focusing ...

EA - Morfologické obory a cytologie

  • 2003 - 2005
    • •
  • 738 tis. Kč
    • •
  • 738 tis. Kč
    • •
  • GA ČR
Project

Optimized dendritic cells loaded with universal tumor antigens as a potent individualized cancer vaccine (NS9871)

This study aims to prepare a clinical grade cancer vaccine based on optimized dendritic cells loaded with tumor associated antigens tailored for each individual patient.......

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 8 171 tis. Kč
    • •
  • 8 171 tis. Kč
    • •
  • MZ
Project

The ability of dendritic cells to stimulate the tumor specific immune response in patients with lymphoid malignancies (NR8092)

The ability of intranodally injected dendritic cells, pulsed with tetanus toxm toxoid or apoptotic tumor cells will be studied in 20-40 patients with chronic dendritic cells will be compared with a respons...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 1 660 tis. Kč
    • •
  • 1 513 tis. Kč
    • •
  • MZ
Project

Induction of immunity against HPV16 E6/E7 oncogenes-induced tumours with peptide- and dendritic cell-based vaccines; immunotherapy of minimal residual tumour disease. (IAA500520605)

This project is focused on the analysis of the differences in the effectiveness of the antigen presentation by dendritic cells in healthy, tumour-bearing and surgically treated animals. Peptide-loaded dendritic cells

EC - Imunologie

  • 2006 - 2009
    • •
  • 3 329 tis. Kč
    • •
  • 3 329 tis. Kč
    • •
  • AV ČR
Project

Impact of the digestion and absorption processes on the final biological activity of diet phytonutrients real health added-value (8X20023)

reaching the targeted cells (such as ovarian cells, mononuclear and dendritic cells). 2 dendritic cells developed from CD14+ blood mononuclear cells and on human blood BDCA-1+ (CD1c+)

Cell biology

  • 2020 - 2022
    • •
  • 203 tis. Kč
    • •
  • 203 tis. Kč
    • •
  • MŠMT
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