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514 (0,091s) •

Project

Differences in parameters of platelets aggregation and blood coagulation between healthy individuals and patients with metabolic diseases (NU21J-02-00021)

that these diseases affect also directly platelet aggregation and blood coagulation. In particular sensitivity of platelets from familial hypercholesterolemic patients are already known phenomena. In this study, we aim to ...

Pharmacology and pharmacy

  • 2021 - 2024
    • •
  • 6 741 tis. Kč
    • •
  • 6 705 tis. Kč
    • •
  • MZ
Project

The use of low-molecular weight heparin during percutaneous trannsluminal coronary angioplasty (PTCA). Laboratory and clinical evaluation. (NA6579)

Use of LMWH during PTCA in stable angina. Evaluation of number, activity and aggregation response of platelets and thrombin activity. Difference in complication occurrence after PTCA in patients treated with UFH and LMWH.......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2001 - 2003
    • •
  • 1 350 tis. Kč
    • •
  • 1 315 tis. Kč
    • •
  • MZ
Project

Platelet activity after on-pump versus off-pump coronary artery bypass surgery. Is there a platelet hyperaggregation after off-pump procedures? (NR8526)

early andlate platelet activity in on-pump and off-pump patients. Platelet activity will be measured by the aggregability test and flow cytometry. Hypothesis of platelet higher......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2005 - 2007
    • •
  • 1 276 tis. Kč
    • •
  • 1 276 tis. Kč
    • •
  • MZ
Project

Aspirin resistance in patients with cardiovascular diseasae and changes of thrombocyte function in aspirin non responders, bioindicators of therapy and prognosis of non responders (NR8036)

of two independent methods (platelet aggregation after induction by propyl gallate and assessment of platelet function by PFA 100 method). The second aim of thestudy is to find and acquired platelet dysfunction (e...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2004 - 2006
    • •
  • 1 769 tis. Kč
    • •
  • 1 717 tis. Kč
    • •
  • MZ
Project

Determination and significance of resistance to antiplatelet therapy (NR9174)

To asses the prognostic impact of laboratory resistance to antiplatelet therapy as measured by either PFA-100 or SPAT (slide platelet aggregation test with cationic propylgallate) in group of 300 patients.......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2007 - 2010
    • •
  • 2 395 tis. Kč
    • •
  • 2 324 tis. Kč
    • •
  • MZ
Project

Effect of various methods of white blood cell reduction on platelet function and the pro-coagulant activity of platelet concentrates (NC7557)

A white blood cell (WBC) reduction of platelet concentrates and its influence on platelet function and activation of coagulation. A comparison of platelet concentrates prepared by a three commonly used techniques for WBC-re...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 4 258 tis. Kč
    • •
  • 4 137 tis. Kč
    • •
  • MZ
Project

PLATELETS - use of cryopreserved platelets for treatment of massive bleeding in combat casualties (OWUVN20170002)

To determine the optimal manufacturing process of cryopreserved platelets, reconstitution and use of cryopreserved platelets in clinical use and in the field, based the quality parameters of cryopreserved platelets after th...

KA - Vojenství

  • 2017 - 2019
    • •
  • 8 833 tis. Kč
    • •
  • 8 833 tis. Kč
    • •
  • MO
Project

Analysis of altered platelet aggregation signalling pathways in diabetes mellitus and the search for an effective antiplatelet drug in these patients (NW25-01-00008)

. In this grant, we aim to see the differences in platelet aggregation pathways in patients on platelets (high glucose and lactate concentration, hyperosmolarity) for the purpose......

Pharmacology and pharmacy

  • 2025 - 2028
    • •
  • 15 269 tis. Kč
    • •
  • 14 789 tis. Kč
    • •
  • MZ
Project

The effect of oxidation stress on the properties of human blood platelets (NK4809)

The study of oxidative stress effect on human blood platelets in platelet concentrates stored at various conditions and on platelets of patients overloaded with iron. The effect of oxido-reduction state of latelet concentra...

FP - Ostatní lékařské obory

  • 1998 - 2000
    • •
  • 4 021 tis. Kč
    • •
  • 3 267 tis. Kč
    • •
  • MZ
Project

Influence of oxidative modification of proteins on activation of human blood platelets (NK6841)

mediate platelet function in vitro. The modification of proteins by oxidant species generated during activation of platelets will be detected. LDL from normal donors LDLand Fbg on platelets will be studied using aggregomet...

FP - Ostatní lékařské obory

  • 2001 - 2003
    • •
  • 2 178 tis. Kč
    • •
  • 2 100 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 514