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12 985 (0,171s) •

Project

Influence of metallothionein on binding of platinum cytostatics to DNA in cancer cells (NV15-28334A)

The objective of the project is to study the binding of platinum cytostatics for study of Pt-DNA and Pt-MT complexes. Liposome based transporter carrying platinum of cancer cells to treatment with platinum...

FD - Onkologie a hematologie

  • 2015 - 2019
    • •
  • 15 620 tis. Kč
    • •
  • 15 620 tis. Kč
    • •
  • MZ
Project

Research of New Cytostatics Based on Platinum Complexes (TA02010781)

The aim of the project is a new platinum drug based on Pt (IV) complex for tumor therapy with the improved efficacy and therapeutic possibilities of an oral drug administration. The project strategy is based on a targeted o...

CC - Organická chemie

  • 2012 - 2014
    • •
  • 15 036 tis. Kč
    • •
  • 9 223 tis. Kč
    • •
  • TA ČR
Project

Study of binding of platinum cytostatics to DNA structure; Influence of metallothionein (IAA401990701)

of patients' treatment could be developed. The binding of platinum cytostatics to ds-DNASuggestion of biosensor for determination of platinum, which could be applied to direct detection of platinum therapeutic con...

CG - Elektrochemie

  • 2007 - 2011
    • •
  • 2 904 tis. Kč
    • •
  • 2 904 tis. Kč
    • •
  • AV ČR
Project

Molecular mechanism of antitumor effect of new cytostatics based on trisubstituted platinum( II ) complexes (GA301/95/1264)

FD - Onkologie a hematologie

  • 1995 - 1997
    • •
  • 1 164 tis. Kč
    • •
  • 1 164 tis. Kč
    • •
  • GA ČR
Project

New Drugs for Cancer Therapy. (PZ-Z2/29)

Application of new drugs for therapy of cancer into the production and clinical praxis. It treats of new platinum complexes for oral administration, liposomat forms of cytostatics, sensilizers for photodynamic therapy, inhibitors of...

FR - Farmakologie a lékárnická chemie

  • 1997 - 2003
    • •
  • 112 811 tis. Kč
    • •
  • 32 666 tis. Kč
    • •
  • MH
Project

Intracellular and extracellular targets for antitumor activity and toxicity of ruthenium complexex (1P05OC070)

complexex of rhutenium as a new class of promising cytostatics effective in tumor cell resistant to platinum cytostatics...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2006
    • •
  • 705 tis. Kč
    • •
  • 522 tis. Kč
    • •
  • MŠMT
Project

New mechanisms of platinum-based drug action as a tool for anticancer therapeutic strategies (NT11201)

The project aims to improve our understanding of novel mechanisms of the effects of platinum (Pt) cytostatics, PPAR? ligands and their combinations at both molecular and cellular level. We will analyze specific genes and proteins re...

FD - Onkologie a hematologie

  • 2010 - 2014
    • •
  • 7 664 tis. Kč
    • •
  • 7 664 tis. Kč
    • •
  • MZ
Project

DNA interactions of polynuclear platinum (ME 152)

Dinuclear and trinuclear platinum complexes represent a novel class of antitumor compounds. The development of polynuclear platinum complexes is based platinum complexes. This joint project has been proposed on the...

FR - Farmakologie a lékárnická chemie

  • 1998 - 2000
    • •
  • 5 344 tis. Kč
    • •
  • 2 127 tis. Kč
    • •
  • MŠMT
Project

Effects of geometric isomerism in antitumor dinuclear platinum complexes on binding properties and conformational alterations in DNA (IAA5004702)

application of platinum complexes with unique DNA binding activities capable of overcoming the problem of cellular resitance to platinum cytostatics already used in clinic of anticancer activity of the new metal-based<...

EB - Genetika a molekulární biologie

  • 1997 - 2000
    • •
  • 5 177 tis. Kč
    • •
  • 2 673 tis. Kč
    • •
  • AV ČR
Project

Affection of DNA conformation by metal-based anticancer drugs. Relations to the development of new cytostatics (GA305/99/0695)

to metal-based cytostatics already used in clinic and of their limited activity against activity of the metal-based compounds and is based on recent progress reached of platinum or ruthenium complexes mos...

CE - Biochemie

  • 1999 - 2001
    • •
  • 3 315 tis. Kč
    • •
  • 2 607 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 12 985