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Projects

5 680 projects (0,198s) •

Project

DNA reactions of aminophoshine platinum(II) compounds. Relations to the development of new platinum antitumor drugs (GA301/98/P231)

This project is aimed at the study of some aspects of molecular mechanism of antitumor activity of selected platinum complexes. For this study, new platinum complexes with amino- phosphine ligands were chosen. Thes...

CE - Biochemie

  • 1998 - 2001
    • •
  • 810 tis. Kč
    • •
  • 750 tis. Kč
    • •
  • GA ČR
Project

DNA interactions of the second generation platinum anticancer drugs (IAA7004805)

axpect of this approach is to 1) find the DNA adduct of platinum complexes most, 2) examine and compare the mechanism of action of platinum complexes structurally distinct from cisplatin, 3) describe reactions of ...

FR - Farmakologie a lékárnická chemie

  • 1998 - 2001
    • •
  • 4 219 tis. Kč
    • •
  • 2 481 tis. Kč
    • •
  • AV ČR
Project

Platinum complexes of biorelevant sulphur ligands (ME 439)

The study of platinum complexes with sulphur containing ligans is of considerable interest in the contex of the tumor chemotheraphy and certain catalytic processes. Therefore new types of platinum complexes with su...

CF - Fyzikální chemie a teoretická chemie

  • 2001 - 2002
    • •
  • 440 tis. Kč
    • •
  • 210 tis. Kč
    • •
  • MŠMT
Project

Structure, recognition and biochemistry of DNA modified by antitumor platinum drugs (IAA5004101)

a systematic and complex theoretical background to the synthesis of novel platinum the mechanism of action of platinum complexes structurally distinct from those used in the clinic. The anticancer activity of ...

EB - Genetika a molekulární biologie

  • 2001 - 2005
    • •
  • 4 464 tis. Kč
    • •
  • 2 629 tis. Kč
    • •
  • AV ČR
Project

Platinum Metal Complexes as DNA-Protein Cross-Linking Agents (ME08017)

This project is aimed to find out data on covalent interactions of DNA modified by platinum complexes with proteins....

BO - Biofyzika

  • 2008 - 2010
    • •
  • 2 226 tis. Kč
    • •
  • 2 226 tis. Kč
    • •
  • MŠMT
Project

Research of New Cytostatics Based on Platinum Complexes (TA02010781)

The aim of the project is a new platinum drug based on Pt (IV) complex for tumor therapy with the improved efficacy and therapeutic possibilities of an oral of the structure ofPt (IV) complex in comparison to ?satraplatin? ...

CC - Organická chemie

  • 2012 - 2014
    • •
  • 15 036 tis. Kč
    • •
  • 9 223 tis. Kč
    • •
  • TA ČR
Project

New platinum (IV) complexes for anticancer therapy (EG15_018/0004605)

New platinum (IV) complexes for anticancer therapy...

FD - Onkologie a hematologie

  • 2015 - 2020
    • •
  • 15 081 tis. Kč
    • •
  • 2 503 tis. Kč
    • •
  • MPO
Project

DNA interactions of polynuclear platinum (ME 152)

Dinuclear and trinuclear platinum complexes represent a novel class of antitumor compounds. The development of polynuclear platinum complexes is based platinum complexes. This joint project has be...

FR - Farmakologie a lékárnická chemie

  • 1998 - 2000
    • •
  • 5 344 tis. Kč
    • •
  • 2 127 tis. Kč
    • •
  • MŠMT
Project

The study of the thermodynamic stability of DNA modified by new anticancer platinum complexes (LZ1K03010)

The project is focused on studies of the mechanism underlying anticancer effects of platinum complexes. The activity of platinum compounds is generally associated with their ability to bind covalently to DNA. The effect of ...

BO - Biofyzika

  • 2003 - 2004
    • •
  • 1 066 tis. Kč
    • •
  • 799 tis. Kč
    • •
  • MŠMT
Project

Effects of geometric isomerism in antitumor dinuclear platinum complexes on binding properties and conformational alterations in DNA (IAA5004702)

application of platinum complexes with unique DNA binding activities capable of overcoming is to find the DNA adduct of dinuclear platinum complexes most likely relevant complexes structurally distinct fr...

EB - Genetika a molekulární biologie

  • 1997 - 2000
    • •
  • 5 177 tis. Kč
    • •
  • 2 673 tis. Kč
    • •
  • AV ČR
  • 1 - 10 out of 5 680