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14 (0,083s)

Project

Biodegradable polymer nanocomposite systems with improved thermal and mechanical properties (8J20PL026)

The project proposal aims at area of development of nanocomposite biodegradable polymer systems with improved thermal and mechanical properties that represent one of the possibilities of responsible attitude to the renewable resources for production ...

Composites (including laminates, reinforced plastics, cermets, combined natural and synthetic fibre fabrics; filled composites)

  • 2020 - 2022
  • 60 tis. Kč
  • 60 tis. Kč
  • MŠMT
Project

Butyrate and glutamine in the local rectal therapy of pouchitis radiation induced proctocolitis and rectal forms of inflammatory bowel diseases (ND6302)

The project deals with the local treatment of pouchitis, postradiation proctocolitis and rectal form of Crohn´s disease be means of rectal application of suppositories containing glutamine and butyrate. We suppose that this treatment improve...

FJ - Chirurgie včetně transplantologie

  • 2000 - 2002
  • 643 tis. Kč
  • 643 tis. Kč
  • MZ
Project

Changes of lipid metabolism and composition during colorectal carcinogenesis - the effects of butyrate and polyunsaturated fatty acids (GAP301/11/1730)

Dietary fiber and polyunsaturated fatty acids(PUFAs), especially omega-3, may function in prevention and therapy of colon carcinogenesis. Based on our previous results we suggest that butyrate and PUFAs alone or in combination induce cellula...

EB - Genetika a molekulární biologie

  • 2011 - 2013
  • 6 874 tis. Kč
  • 6 874 tis. Kč
  • GA ČR
Project

The interaction of cytokine TNF-alpha with butyrate during differentiation and apoptosis of color epithelial cells (GP524/02/P051)

This project is based on our own recently reported results. We demonstrated that TNF-alpha inhibits differentiation and increases apoptosis induced by butyrate in the HT-29 colon adenocarcinoma cell line. The proposed project concentrates on...

ED - Fyziologie

  • 2002 - 2004
  • 1 139 tis. Kč
  • 723 tis. Kč
  • GA ČR
Project

Gut microbiota and host intestinal inflammation. Mechanism of bacterial and butyrate action in alleviating the consequences of dysbiosis (GA19-08294S)

Short-chain fatty acids (SCFA-butyrate, propionate, acetate) are the intestinal bacterial fermentation of non-digestible fiber final products. Number of studies demonstrated their anti-inflammatory properties, positive effects on intestinal ...

Physiology (including cytology)

  • 2019 - 2023
  • 14 462 tis. Kč
  • 14 426 tis. Kč
  • GA ČR
Project

Mechanisms of the cell death induced by dietary lipid components and endogenous apoptotic regulators in colon epithelial cells (GA524/04/0895)

The molecular mechanism regulating anoikis (detachment-induced apoptosis) are not yet fully understood. The project follows up with our previous results showing interaction of polyunsaturated fatty acids (PUFAs) with butyrate and endogenous ...

ED - Fyziologie

  • 2004 - 2006
  • 3 247 tis. Kč
  • 3 247 tis. Kč
  • GA ČR
Project

Lipid nutritional factors as modulators of xenobiotic metabolism and toxicity in colon epithelial cells (GA13-09766S)

or short chain fatty acid butyrate, which both have a significant impact on colon...

DN - Vliv životního prostředí na zdraví

  • 2013 - 2017
  • 8 614 tis. Kč
  • 8 614 tis. Kč
  • GA ČR
Project

Artificial blood components biocompatible fluoroalkyl derivatives of polyhydroxy compounds and polyethers (GA203/98/1174)

Emulsions of perfluorocompounds are a subject of contemporary clinical trials as blood substitutes. Medicinal applications of these oxygen carriers comprise also curing of blood and ischaemic deseases, organ preservation, cell culture technology ets....

CC - Organická chemie

  • 1998 - 2000
  • 1 427 tis. Kč
  • 1 102 tis. Kč
  • GA ČR
Project

The role of extracellular matrix-mediated cell adhesion in maintenance of colonic tissue homeostasis and in colon carcinogenesis (GA305/09/1526)

membersand to differentiation inductor butyrate as the result of the changes in cell-ECM of butyrate on TNF-alpha-mediated mestatic potential increase of intestinal epithelial......

ED - Fyziologie

  • 2009 - 2011
  • 2 718 tis. Kč
  • 2 718 tis. Kč
  • GA ČR
Project

Regulation of PKC beta 2 in malignant and differentiating colorectal adenocarcinoma cells (GP301/02/D159)

epithelial cells of the large intestine. HT29 cells differentiate after sodium butyrate...

EB - Genetika a molekulární biologie

  • 2002 - 2005
  • 745 tis. Kč
  • 745 tis. Kč
  • GA ČR
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