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8 (0,072s) •

Project

Biosynthesis of asukamycin polyketide chains Prospects for hybrid antibotics (KJB5020306)

typically consist of two cyclic carbon unitslinked by two polyketide chains structure with that of manumycin gene cluster, focusing on thebiosynthesis of polyketide of the genes encoding relevant polyketide synthases of bo...

EE - Mikrobiologie, virologie

  • 2003 - 2005
    • •
  • 1 267 tis. Kč
    • •
  • 1 109 tis. Kč
    • •
  • AV ČR
Project

Unique biosynthetic enzymes as the key to novel bioactive compounds (NV17-30091A)

aminolevulinate synthase and a novel type of type II polyketides synthase specific for short linear polyketide chains, will be employed in the project.......

EE - Mikrobiologie, virologie

  • 2017 - 2020
    • •
  • 7 493 tis. Kč
    • •
  • 7 493 tis. Kč
    • •
  • MZ
Project

Bioinspired Approaches to Polycyclic Phenolic Indane- and Tetraline-Containing Stilbenolignans, Stilbenes, and Polyketides (GA19-22085S)

Polycyclic phenolic natural products containing indane or tetraline units are distinguished by their significant biological activities, such as antitumor, antiinflammatory, or antimicrobial activities. Many classes exist and among them stilbenolignan...

Organic chemistry

  • 2019 - 2023
    • •
  • 2 898 tis. Kč
    • •
  • 2 508 tis. Kč
    • •
  • GA ČR
Project

Aromatic and isoprenoid cytokinins in poplar biosynthesis and perception (GA15-16888S)

, phenylpropanoid and polyketide pathways using immunoaffinity extraction, scintilation counter...

CE - Biochemie

  • 2015 - 2019
    • •
  • 4 248 tis. Kč
    • •
  • 4 248 tis. Kč
    • •
  • GA ČR
Project

New manumycins by means of the specific genetic screening of natural streptomycete isolates and of the combinatorial biosynthesis (LH12191)

in the structure of manumycins, mainly in the upper polyketide chain, which is the main...

EE - Mikrobiologie, virologie

  • 2012 - 2015
    • •
  • 2 375 tis. Kč
    • •
  • 2 375 tis. Kč
    • •
  • MŠMT
Project

Collaborative research on the assessment to the safety and functions for Monascus products based on European standards (8H17043)

Main project goal is to support joint solution of specified problems by personal meetings of Czech and Chinese collaborators. The joint research interest can be defined as evaluation of safety and testing biological effects of traditional Chinese pro...

GM - Potravinářství

  • 2017 - 2018
    • •
  • 268 tis. Kč
    • •
  • 268 tis. Kč
    • •
  • MŠMT
Project

The effect of manumycin-related compounds on innate immunity cells and their interactions (NT13012)

, construction of cosmid libraries, and genetic manipulations with the upper polyketide chain...

EC - Imunologie

  • 2012 - 2015
    • •
  • 7 827 tis. Kč
    • •
  • 7 827 tis. Kč
    • •
  • MZ
Project

Evolution of secondary metabolism in actinomycetes exploitation of genetic variability (IAA600200519)

secondary metabolic genes coding for common enzymes, e.g. polyketide synthases, or rare...

EE - Mikrobiologie, virologie

  • 2005 - 2009
    • •
  • 3 127 tis. Kč
    • •
  • 3 127 tis. Kč
    • •
  • AV ČR
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