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14 031 (0,104s) •

Project

Polyomavirus Pseudocapsids as Vectors Applications for Genetic and Immunological Therapeutic Purposes of Modified VP1 Pseudocapsids (OK 372)

to the nuclus, b) to manipulate original viral structures for the specific tissue targeting of immune system of organism on the presence of viral structures and to manipulate the structures to mask targets of antibodies......

EE - Mikrobiologie, virologie

  • 1998 - 2001
    • •
  • 2 773 tis. Kč
    • •
  • 1 853 tis. Kč
    • •
  • MŠMT
Project

Studies of molecular mechanism of polyomavirus infection aimed to the development of capsid-like particles for the gene delivery systém (GA204/03/0593)

intotarget cells. On the basis of unique properties of the polyomavirus major structural protein, VP1 (ability of spontaneous self-assembly, receptor recognition, DNA nonStudying the properties of viral coat s...

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 3 271 tis. Kč
    • •
  • 3 271 tis. Kč
    • •
  • GA ČR
Project

Polyomaviruses Cellular responses to virion components (GA16-07977S)

of the major capsid protein VP1 with microtubules, likely affecting cell cycle progression will be studied. Also, further screening of VP1 interactions will be performed. The research......

EE - Mikrobiologie, virologie

  • 2016 - 2020
    • •
  • 7 254 tis. Kč
    • •
  • 7 254 tis. Kč
    • •
  • GA ČR
Project

Tumour virus antigens Properties, functions and interactions with host cell structures (VS96135)

of polyomaviral proteins and their interactions with host cell proteins. We would likeThe study of viral replication, functions of viral proteins and their interactions with host cell structures helps to ...

EA - Morfologické obory a cytologie

  • 1996 - 2000
    • •
  • 15 063 tis. Kč
    • •
  • 11 286 tis. Kč
    • •
  • MŠMT
Project

Expanded and refined instrumentation IET (ED2.1.00/19.0388)

The main objective is to strengthen and develop the following research programs: VP1 - Research energy waste processing VP2 - technology research removing products on the environment VP1 and VP2 is solved by the applicant Project Te...

DM - Tuhý odpad a jeho kontrola, recyklace

  • 2015 - 2015
    • •
  • 17 980 tis. Kč
    • •
  • 2 697 tis. Kč
    • •
  • MŠMT
Project

Study of the novel human polyomavirus (MCPyV) discovered in Merkel cell carcinomas. (GAP304/10/1511)

construction of expression vectors for production of individual viral proteins in insect in cells and functions of individual MCPyV proteins will be studied. Virus-like......

EE - Mikrobiologie, virologie

  • 2010 - 2014
    • •
  • 7 567 tis. Kč
    • •
  • 7 567 tis. Kč
    • •
  • GA ČR
Project

Design, characterization and mechanism of action of novel inhibitors of HIV assembly (GA13-19561S)

AIDS remains one of the major infectious diseases. The current therapeutic arsenal against HIV comprises compounds blocking all major steps of HIV replication of HIV capsid protein, thereby preventing virus assembly. The de...

EB - Genetika a molekulární biologie

  • 2013 - 2016
    • •
  • 11 267 tis. Kč
    • •
  • 11 267 tis. Kč
    • •
  • GA ČR
Project

MAMMALIAN MICROSOMAL CYTOCHROME P450 INTERACTION WITH REDOX PARTNERS - TOPOLOGY AND STRUCTURE-FUNCTION RELATIONSHIPS (GAP207/12/0627)

is an opportunity to examine native structure of the proteins directly in the membraneThe grant proposal is aimed to reveal the molecular structure, topology, organization and structure-function relationships of c...

CE - Biochemie

  • 2012 - 2015
    • •
  • 7 574 tis. Kč
    • •
  • 7 574 tis. Kč
    • •
  • GA ČR
Project

Reliable calculations and predictions of NMR chemical shifts for the structural characterization of phosphorylated intrinsically disordered proteins (GJ19-14886Y)

of the proteins become a major hurdle in structural studies by experimental techniques, the project will facilitate the structural characterization of the proteins in question disordered proteins

Physical chemistry

  • 2019 - 2022
    • •
  • 5 250 tis. Kč
    • •
  • 5 250 tis. Kč
    • •
  • GA ČR
Project

Blood coagulation proteins and oxidative stress (GA303/03/0249)

are protein adsorption and activation. Fibrinogen seems to play a major role becauseThere is a mounting evidence that oxidatively modified forms of proteins accumulate during oxidative stress. It was found that plasma ...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2003 - 2005
    • •
  • 4 688 tis. Kč
    • •
  • 3 585 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 14 031