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3 248 (0,084s) •

Project

Mechanistic insights into microtubule polyglutamylations by tubulin tyrosine ligase-like 11 (TTLL-11) (GA23-07149S)

variants together with tubulins harboring defined post-translational modificationsMicrotubules (MTs) are decorated by a variety of post-translational modifications that control the prope...

Biochemistry and molecular biology

  • 2023 - 2025
    • •
  • 9 864 tis. Kč
    • •
  • 9 864 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of microtubule dysfunction in Parkinson's disease (LUC23123)

to the understanding of the role of neuronal tubulin isotypes and their post-translational modifications in the pathogenesis of PD. The objectives of the project include: 1/ Analysis cells after PD neurotoxin trea...

Cell biology

  • 2023 - 2026
    • •
  • 5 400 tis. Kč
    • •
  • 5 400 tis. Kč
    • •
  • MŠMT
Project

Molecular analysis of structure and function of gamma-tubulin (GA204/98/1054)

will be used for finding of elution conditions for isolation of soluble gama-tubulin(s) from cultured mammalian cell lines. Purified gama-tubulin will be thereafter usefor studyof its post-translational modifi...

EA - Morfologické obory a cytologie

  • 1998 - 2000
    • •
  • 1 863 tis. Kč
    • •
  • 1 318 tis. Kč
    • •
  • GA ČR
Project

Analysis of gama-tubulin forms and other spindle pole components (GA304/04/1273)

. The key component of centrosomes is gamma-tubulin that is important for nucleation of microtubules but may have other functions, which could be regulated by post-translational modifications. The aim of this resea...

EA - Morfologické obory a cytologie

  • 2004 - 2006
    • •
  • 1 911 tis. Kč
    • •
  • 1 911 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms in the regulation of mammalian sperm capacitation (LUAUS25072)

on the identification of proteins and their post-translational modifications, the detection of which) Detection of enzymes involved in post-translational modifications of sperm proteins 3) Assess...

Cell biology

  • 2025 - 2027
    • •
  • 7 471 tis. Kč
    • •
  • 6 809 tis. Kč
    • •
  • MŠMT
Project

Molecular basis of substrate recognition by histone deacetylase 6. (GA15-19640S)

cellular processes and its extent and importance match other post-translational modifications, such as phosphorylation. Histone deacetylase 6 (HDAC6) stands out with tubulin, the most prominent HDAC6 target. We ha...

CE - Biochemie

  • 2015 - 2019
    • •
  • 6 852 tis. Kč
    • •
  • 6 852 tis. Kč
    • •
  • GA ČR
Project

Unravelling the regulation and interactions of p63. (GA19-06530S)

, but, unlike p53, how p63 is regulated at transcriptional/post-transcriptional levels is unclear. Similarly, unlike the myriad of post-translational modifications known on p53 conditions. We will use state-of-the-...

Cell biology

  • 2019 - 2023
    • •
  • 8 388 tis. Kč
    • •
  • 7 809 tis. Kč
    • •
  • GA ČR
Project

Translating microtubule envelope sectioning into cytoskeletal structure and function (GA20-04068S)

Modulating the accessibility of microtubules for associated proteins is a fundamental mechanism of cytoskeletal self-organization. Our recent findings show that the intrinsically-disordered protein (IDP) tau, in a phase separation-like process, rever...

Biophysics

  • 2020 - 2022
    • •
  • 7 804 tis. Kč
    • •
  • 7 804 tis. Kč
    • •
  • GA ČR
Project

Molecular analysis of components that make up microtubule organizing center (IAA5052605)

This proposal aims to understand the role gama-tubulin and other components and some newly prepared monoclonal antibodies against gama-tubulin will be employed for purification of this protein. Purified gama-tubulin will be...

CE - Biochemie

  • 1996 - 1998
    • •
  • 1 887 tis. Kč
    • •
  • 1 137 tis. Kč
    • •
  • AV ČR
Project

Differential proteome analysis of bacterial Francisella tularensis glyco- and phospho- proteins (ME08105)

Post-translational modifications (PTM) of proteins play crucial role in the assembly, degradation, structure, and function of exprimed genes. PTM of proteins of Francisella tularensis proteins, their post-trans...

CB - Analytická chemie, separace

  • 2008 - 2010
    • •
  • 2 802 tis. Kč
    • •
  • 2 082 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 3 248