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1 586 (0,161s) •

Project

Posttranslation protein modifications in activated blood platelets (NS10633)

The aim of the project is identication of posttranslation modifications (PTM) in proteins of both activated and non activated platelets with a special fokus on redox-dependent protein modifications. The platelets will be ac...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2009 - 2011
    • •
  • 6 990 tis. Kč
    • •
  • 6 990 tis. Kč
    • •
  • MZ
Project

Posttranslational modification of Dishevelled (KJB501630801)

and other possible posttranslational modifications. We expect that our findings by analyzing and mapping in detail the physiologically relevant posttranslational modifications of Dvl. We plan to use several approa...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 1 290 tis. Kč
    • •
  • 1 290 tis. Kč
    • •
  • AV ČR
Project

Influence of Dishevelled posttranslational modifications on Wnt signaling pathways (GP13-31488P)

mechanism very probably lies in the Dvl posttranslational modifications, but the exact posttranslational modifications induced by Dvl regulators using mass spectrometry. The role of individual identified modif...

EB - Genetika a molekulární biologie

  • 2013 - 2015
    • •
  • 1 806 tis. Kč
    • •
  • 1 806 tis. Kč
    • •
  • GA ČR
Project

Posttranslational phosphorylations of proteins and peptides (GA203/98/P201)

Phosphorylation of proteins is posttranslational modification, which of serine, tyrosine or threonine. Modification by phosphoryl group changes dramatically and cancerogenesis were proved. Modification of enzymes b...

CE - Biochemie

  • 1998 - 2001
    • •
  • 802 tis. Kč
    • •
  • 712 tis. Kč
    • •
  • GA ČR
Project

Novel mechanisms of CYP3A4 enzyme regulation based on posttranslational modification of nuclear receptors - implications for pharmacotherapy (GAP303/12/0472)

of posttranslational modifications of the NRs in hepatic CYP3A4 regulation. The aim of the project pathway on posttranslational status and activity of PXR and CAR in the hepatic......

FR - Farmakologie a lékárnická chemie

  • 2012 - 2016
    • •
  • 7 548 tis. Kč
    • •
  • 7 548 tis. Kč
    • •
  • GA ČR
Project

Study of posttranslation modification of the tumor suppressor protein p53, its homologues and interacting proteins in human cancer cell lines (GP301/07/P160)

in detail posttranslational modifications of the p53 protein, influence of p53 modification on its DNA binding and changes of the p53 activity induced by genotoxicDetailed knowledge of modification and DNA binding...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 1 365 tis. Kč
    • •
  • 1 365 tis. Kč
    • •
  • GA ČR
Project

Nature and role(s) of the posttranslational modification(s) required for activities of an RTX toxin the adenylate cyclase toxin of bordetella pertussis (GA310/95/1048)

EE - Mikrobiologie, virologie

  • 1995 - 1997
    • •
  • 1 030 tis. Kč
    • •
  • 1 030 tis. Kč
    • •
  • GA ČR
Project

Gene expression and posttranslational modification during germination of aerial spores of streptomycetes (GA203/02/1421)

Aim of the proposal is to clarify gene expression during germination of aerial spores of streptomycetes. Synchronous germination of spores makes it possible to examine expression and posttranslational modification of proteins before...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 3 109 tis. Kč
    • •
  • 1 573 tis. Kč
    • •
  • GA ČR
Project

Estimation of collagen and its modifications in tissues based on marker peptide fragments (GA203/00/D032)

It is proposed to apply advanced (capillary) electromigration methods for the characterization and localization of nonenzymatic posttranslational modifications arising from the interactions of vascular wall collagen with (i) metabol...

CB - Analytická chemie, separace

  • 2000 - 2003
    • •
  • 1 268 tis. Kč
    • •
  • 647 tis. Kč
    • •
  • GA ČR
Project

Investigation of posttranslational modifications of proteins with carbonyl compounds by using MALDI-TOF mass spectrometry and capillary electrophoresis. (ME 230)

Investigation of posttranslational modifications of proteins with carbonyl compounds by using MALDI-TOF mass spectrometry and capillary electrophoresis. In this project three types of protein modification will be studied: r...

CB - Analytická chemie, separace

  • 1998 - 2000
    • •
  • 1 314 tis. Kč
    • •
  • 264 tis. Kč
    • •
  • MŠMT
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