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7 602 (0,196s) •

Project

Replication of mammalian genome ? 4D view (KJB500390701)

of reconstitution of early and late RDs will be tested. Finally, formation of pre-initiation complex at early and late replicating origins will be addressed with respect......

EA - Morfologické obory a cytologie

  • 2007 - 2009
    • •
  • 1 710 tis. Kč
    • •
  • 1 710 tis. Kč
    • •
  • AV ČR
Project

Deciphering Origins of DNA replication in genome integrity (GM22-20303M)

initiates at replication origins by the formation of pre-replicative complexes (pre-RCs). The pre-RCs are essential drivers of replication forks; however, the mechanism(s) of pre-RCs formation an...

Cell biology

  • 2022 - 2026
    • •
  • 24 928 tis. Kč
    • •
  • 24 928 tis. Kč
    • •
  • GA ČR
Project

Development of initial genetic resources of cereals with a complex of economic and qualitative parameters (IE0950975078)

Development of initial genetic resources of cereals with a complex of economic and qualitative parameters...

GE - Šlechtění rostlin

  • 1995 - 1998
    • •
  • 5 989 tis. Kč
    • •
  • 4 375 tis. Kč
    • •
  • MZe
Project

Analysis of splicing factor mutations connected with the inherited retinitis pigmentosa (1K05009)

and hPrp3 influence the formation of splicing complexes and pre-mRNA splicing.Pre-mRNA splicing is one of the key steps in the regulation of gene expression and mutations influencing pre-mRNA splicing were found i...

EB - Genetika a molekulární biologie

  • 2005 - 2006
    • •
  • 1 506 tis. Kč
    • •
  • 1 481 tis. Kč
    • •
  • MŠMT
Project

Mitoribosome in Trypanosoma brucei biogenesis and unique traits of a divergent protein synthesis machine (GJ20-04150Y)

, a putative post-recycling/pre-initiation complex. Here, we propose to build the atomic models of the latter two complexes. Next, we will complement the structural data) our cryoEM datasets yielded sub-3.5 Å maps ...

Biochemistry and molecular biology

  • 2020 - 2023
    • •
  • 6 855 tis. Kč
    • •
  • 6 855 tis. Kč
    • •
  • GA ČR
Project

Regulating the balance between differentiation and pluripotency; molecular characterisation of p38-MAPK function in mouse blastocyst ICM maturation. (GA18-02891S)

(supplementing those we have hypothesised) responsible for initiating PrE differentiationWe previously uncovered a novel role for p38-Mapks in enabling initially the primitive endoderm (PrE) lineage, in a process ...

Developmental biology

  • 2018 - 2021
    • •
  • 6 455 tis. Kč
    • •
  • 6 247 tis. Kč
    • •
  • GA ČR
Project

Legal, Social and Psychological, medica and Therapeutic Aspects of Protective Measures (RN19992001006)

Faktors analysis (legal and psychologic-pedagogical, medical and therapeutic) of imposing and implemeating protective measures at presenting initiatives for deepening preventive effect and social integracion.......

AG - Právní vědy

  • 1999 - 2001
    • •
  • 412 tis. Kč
    • •
  • 412 tis. Kč
    • •
  • MV
Project

The dynamics of dense star clusters with primordial binaries and massive black holes (GA20-21855S)

code for rapidly dynamically pre-evolving a binary-rich initial stellar population clusters initialised with this pre-evolved population will allow a unique link between a realistic initial stellar population and ...

Astronomy (including astrophysics,space science)

  • 2020 - 2022
    • •
  • 6 085 tis. Kč
    • •
  • 6 085 tis. Kč
    • •
  • GA ČR
Project

Study of integrase and pre-integration complex of monkey retrovirus (GP203/05/P557)

. Second part of this work will be focused on a detail characterization of M-PMV pre-integration complexes (PICs), which are formed immediately after reverse transcription......

CE - Biochemie

  • 2005 - 2007
    • •
  • 1 140 tis. Kč
    • •
  • 1 140 tis. Kč
    • •
  • GA ČR
Project

New insights into cooperation of micro- and nano-scale elementary structural chromatin units in decision-making on DNA damage repair pathway (NANOREP) (GC20-04109J)

Based on the novel strategy we proposed, the project attempts to bring the answers on a long-time unresolved fundamental biological ‘hen and egg’ question, whether it is the pre-existing chromatin architecture that determines initiation<...

Cell biology

  • 2020 - 2022
    • •
  • 9 816 tis. Kč
    • •
  • 9 786 tis. Kč
    • •
  • GA ČR
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