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6 612 (0,122s) •

Project

Replication of mammalian genome ? 4D view (KJB500390701)

complex at early and late replicating origins will be addressed with respectEucaryotic DNA replication ensures accurate and efficient genome duplication. Although a lot of findings about DNA replication is known, ...

EA - Morfologické obory a cytologie

  • 2007 - 2009
    • •
  • 1 710 tis. Kč
    • •
  • 1 710 tis. Kč
    • •
  • AV ČR
Project

Deciphering Origins of DNA replication in genome integrity (GM22-20303M)

DNA replication is fundamental to cell proliferation, but its malfunctions can cause genome instability and trigger diseases including cancer. DNA replication initiates at replication origins by the formation of pre

Cell biology

  • 2022 - 2026
    • •
  • 24 928 tis. Kč
    • •
  • 24 928 tis. Kč
    • •
  • GA ČR
Project

Study of integrase and pre-integration complex of monkey retrovirus (GP203/05/P557)

replication. Mason-Pfizer Monkey Virus (M-PMV), a representative of ß-retrovirus family. Second part of this work will be focused on a detail characterization of M-PMV pre-integration complexes (PICs), which are formed imm...

CE - Biochemie

  • 2005 - 2007
    • •
  • 1 140 tis. Kč
    • •
  • 1 140 tis. Kč
    • •
  • GA ČR
Project

Exploring mechanisms of DNA replication restart upon collisions between transcription and replication complexes (GA19-07674S)

Transcription-replication collisions (TRCs) represent a significant source of genomic instability in cells experiencing DNA replication stress. Although, understanding of how a replication fork restarts DNA synthesis upon a...

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 10 396 tis. Kč
    • •
  • 9 563 tis. Kč
    • •
  • GA ČR
Project

Role of DNA clamp complexes in the maintenance of genome stability in Arabidopsis (GA25-15186S)

The PCNA and 9-1-1 DNA clamps serve as processivity factors for the replicative DNA Polymerases and as scaffolds for proteins involved in replication, chromatin is ensured by the four RFC complexes involved in their loading...

Plant sciences, botany

  • 2025 - 2027
    • •
  • 9 975 tis. Kč
    • •
  • 9 975 tis. Kč
    • •
  • GA ČR
Project

Role of RECQ5 DNA helicase in maintenance of genomic stability (GA204/09/0565)

-transcription complexes that can cause replication fork collapse; (iv) to prove that RECQ5DNA replication forks often pause upon encounter of DNA damage in the DNA replication forks and restore the replication...

EB - Genetika a molekulární biologie

  • 2009 - 2013
    • •
  • 8 570 tis. Kč
    • •
  • 8 570 tis. Kč
    • •
  • GA ČR
Project

Deciphering the relationship between homologous recombination and gene silencing (GA23-05284S)

The simultaneous activity of transcription and replication or DNA repair is an inherent mechanism of the recombination-dependent replication pathway. We will show that silencing depends on replication fork barriers and occu...

Biochemistry and molecular biology

  • 2023 - 2025
    • •
  • 7 260 tis. Kč
    • •
  • 7 260 tis. Kč
    • •
  • GA ČR
Project

Structural characterisation of RAD51-G4 complex and its biological role (GA25-17326S)

of the molecular mechanism of RAD51-G4 complex interaction and its role in DNA replication DNA replication or transcription. RAD51 is a recombinase that functions in homologous recombination, promotes the processing of sta...

Biochemistry and molecular biology

  • 2025 - 2027
    • •
  • 8 703 tis. Kč
    • •
  • 8 703 tis. Kč
    • •
  • GA ČR
Project

Identification of protein complexes associated with genotoxic RNA DNA hybrids and their role in maintenance of genomic stability (LH14037)

The aim of this project is to prepare tools for the isolation of proteins associated with R-loops, identify proteins associated with these structures under different conditions promoting transcription/replication collision and R-loop formati...

EB - Genetika a molekulární biologie

  • 2014 - 2016
    • •
  • 1 823 tis. Kč
    • •
  • 1 823 tis. Kč
    • •
  • MŠMT
Project

Contribution of (pre)lamin A - phosphoinosites complexes to intranuclear order. (GA16-03346S)

functions, such as regulation of gene expression, DNA replication, DNA repair, chromatin preliminary data demonstrate that lamin A forms a complex with nuclear myosin I to characterize these complexes in detail by biochemi...

EA - Morfologické obory a cytologie

  • 2016 - 2018
    • •
  • 9 051 tis. Kč
    • •
  • 8 349 tis. Kč
    • •
  • GA ČR
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