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56 (0,064s) •

Project

Neuroactive steroids in male reproduction (1A8235)

The aim of the project is the study of the participation of neuroactive steroids (pregnenolone and isomers of pregnanolone) in the course of the male orgasm and ejaculation as a basis of potential treatment of their disturbances.......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 1 331 tis. Kč
    • •
  • 1 287 tis. Kč
    • •
  • MZ
Project

20alpha-hydroxy-metabolites of neuroactive pregnenolone isomers, progesterone and pregnenolone around parturition and the importace in physiology and diagnostics (NR9156)

The project investigates a possibility of influencing of the onset of parturition by changes in activity of 20alfa-hydroxysteroid dehydrogenase, which could contribute to the accelerating catabolism of progesterone and neuroinhibiting pregnanolon...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2009
    • •
  • 7 161 tis. Kč
    • •
  • 5 883 tis. Kč
    • •
  • MZ
Project

Changes in the profile of steroids and their neuroactive metabolites in relation to prediction of term (NS9834)

, 5beta- and 3alpha- isomers of pregnanolone in human. The obtained information-pregnanolonone isomers and competing 3beta-isomers or sulfated antagonists. The main focus......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2008 - 2011
    • •
  • 5 646 tis. Kč
    • •
  • 5 646 tis. Kč
    • •
  • MZ
Project

Haptens for immunoassays of neuroactive steroids of pregnanolone type (GA203/04/0123)

isomers of pregnanolone and use them as components for development of immunoassaysNatural pregnanolone derivatives with hydroxyl group in position 3 and ketone,5beta(pregnanolone) have function both in the central...

CC - Organická chemie

  • 2004 - 2005
    • •
  • 1 051 tis. Kč
    • •
  • 1 051 tis. Kč
    • •
  • GA ČR
Project

New Methods for Determination of Neuroactive Steroids and Their Polar Conjugates in Human Tissues and Serum (NR7768)

We intend to develop new high sensitive and selective methods for determination of neuroactive pregnanolone isomers by means of gass chromatgraphy with mass spectrometry (GC-MS) with new derivatization techniques. The new quick and ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 4 691 tis. Kč
    • •
  • 4 194 tis. Kč
    • •
  • MZ
Project

Laser separation of radioactive isotopes and nuclear isomers of europium (GA202/97/0445)

of the effective separation of nuclear isomers on examples of radioactive isomers of europium. Separation of the nuclear isomers has a large methodical and practical importance of 'exotic' isomer for investigation...

BG - Jaderná, atomová a molekulová fyzika, urychlovače

  • 1997 - 1998
    • •
  • 680 tis. Kč
    • •
  • 500 tis. Kč
    • •
  • GA ČR
Project

Neuroendocrine and neurophysiological changes in patients after brain injury. (IZ4207)

We will follow the levels of LH, FSH, PRL, E2, testosterone, dihydrotestosterone, cortisol, TSH, fT4, progesterone and its brain metabolite, pregnanolone and its relationship to brainedema evolution in patients after brain contusion. We will...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1997 - 1999
    • •
  • 1 787 tis. Kč
    • •
  • 1 461 tis. Kč
    • •
  • MZ
Project

Shape of mobility peaks as a tool for discrimination of isomers by ion mobility-mass spectrometry (GA23-07254S)

Ion mobility coupled to mass spectrometry enables the separation of isomers, which, however, is limited by its low resolving power. In the separation of isomers of one isomer, but the zones of the two isomers still...

Analytical chemistry

  • 2023 - 2025
    • •
  • 5 927 tis. Kč
    • •
  • 5 927 tis. Kč
    • •
  • GA ČR
Project

Electron density and structure of light-induced metastable linkage isomers (GC202/07/J007)

and the structure of complexes, in which light-induced metastable linkage isomers can of these metastable linkage isomers shall be identified, which allows for deducing and testing. Two long-lived metastable linkage isomers

BM - Fyzika pevných látek a magnetismus

  • 2007 - 2009
    • •
  • 1 305 tis. Kč
    • •
  • 1 305 tis. Kč
    • •
  • GA ČR
Project

Evaluation of chiral SFC-MS for the analysis of positional isomers and enantiomers of biologically significant lipids (GA24-12234S)

to sample complexity, time- and experimentally demanding isomer separation, or lack isomers and enantiomers. This project focuses on multidisciplinary research of separation selectivity of lipid classes and positional isomers

Analytical chemistry

  • 2024 - 2026
    • •
  • 7 302 tis. Kč
    • •
  • 7 302 tis. Kč
    • •
  • GA ČR
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