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2 762 (0,082s) •

Project

Use of New Molecular Genetic Methods for the Early Detection of Disease Progression in Patients with Resectable, Primary Colorectal Carcinoma Based On Circulating Tumor Cells and Free Tumor Nucleic (NS9809)

the course of subsequent treatment and follow-up. Tissue resections from primary tumorsProject is directed at detection of circulating tumor cells and free circulating tumor nucleic acids from peripheral blood of ...

FE - Ostatní obory vnitřního lékařství

  • 2008 - 2011
    • •
  • 7 755 tis. Kč
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  • 7 755 tis. Kč
    • •
  • MZ
Project

Humanized patient-derived murine xenografts for experimental therapy of hematologic malignancies and for the study of in vivo acquired drug-resistance (NV19-08-00144)

of the principle obstacle in PDX derivation is low engraftment of primary tumor cells within of mesenchymal stem cells that would support survival and growth of primary tumor cellsHematologic malignancies represen...

Hematology

  • 2019 - 2022
    • •
  • 16 966 tis. Kč
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  • 16 966 tis. Kč
    • •
  • MZ
Project

Elucidating the relationship between Trop2 expression and metastasis in cancer (GA24-11793S)

, Trop2 depletion led to a paradoxical reduction in primary tumor size, but increased the context-dependent role of Trop2 in metastasis, the paradox of Trop2 in primary tumorTrop2 is a transmembrane glycoprotein im...

Pathology

  • 2024 - 2026
    • •
  • 9 360 tis. Kč
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  • 9 221 tis. Kč
    • •
  • GA ČR
Project

Specific metastatic site prediction due to the expression of "homing" factors in circulating tumor cells in experimental metastatic models (ME10045)

expression of CTC homing factors. CTC are disseminated cells produced by primary tumor expression analysis of primary tumor cells, circulating tumor cells and metastatic cells should help us to identify t...

EB - Genetika a molekulární biologie

  • 2010 - 2012
    • •
  • 3 063 tis. Kč
    • •
  • 3 063 tis. Kč
    • •
  • MŠMT
Project

Telomere homeostasis from colorectal adenoma to metastatic cancer. (GA21-27902S)

to migrate from the primary site of the tumor. Here we will investigate telomere proliferation, survival and differentiation. The hTERT subunit adopts tumor suppressing cancer. In advanced tumors the telomerase ac...

Oncology

  • 2021 - 2024
    • •
  • 12 958 tis. Kč
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  • 12 958 tis. Kč
    • •
  • GA ČR
Project

Explaining transition from stage II to stages III and IV colon cancer through assessment of tumor microenvironment and actionable somatic mutations (NW24-03-00521)

therapy. Our hypothesis posits that histopathological changes in the primary tumor and RLNs along with immune tumor microenvironment (TME) and cancer genomics will reveal patterns between primary tumor, ...

Oncology

  • 2024 - 2027
    • •
  • 14 502 tis. Kč
    • •
  • 14 502 tis. Kč
    • •
  • MZ
Project

TUMOR CELL AND MUTATIONAL LANDSCAPE IN COLORECTAL CANCER DEVELOPMENT (NU21-03-00506)

+ and CD8+) in the primary tumor. The immunoscore was shown to provide a better covering normal colon tissue, primary tumor and metastasis from the same individual. We, primary tumor and liver met...

Oncology

  • 2021 - 2025
    • •
  • 12 905 tis. Kč
    • •
  • 12 905 tis. Kč
    • •
  • MZ
Project

The value of tumor marker follow up in diagnosing, monitoring and prognosing primary breast cancer. (IZ3767)

FD - Onkologie a hematologie

  • 1996 - 1998
    • •
  • 1 681 tis. Kč
    • •
  • 1 661 tis. Kč
    • •
  • MZ
Project

The role of microRNA expression in HPV-associated and HPV-independent head and neck tumors (GAP304/12/2244)

their role in the development of malignant tumors. Levels of expression of some miRNAs are different in tumors and in normal tissues and miRNA expression profiles are specific for different tumors. Studies on head and neck...

FF - ORL, oftalmologie, stomatologie

  • 2012 - 2017
    • •
  • 7 056 tis. Kč
    • •
  • 7 056 tis. Kč
    • •
  • GA ČR
Project

Targeting genomic diversity in primary and recurrent gliomas for further understanding of brain tumor pathogenesis. (NU21-04-00100)

Diffuse gliomas are the most common primary brain tumors in adults of tumors that differ in malignant potential and therapy response. The treatment, despite recent molecular genetic findings, our knowledge of the evolution ...

Oncology

  • 2021 - 2025
    • •
  • 13 243 tis. Kč
    • •
  • 13 193 tis. Kč
    • •
  • MZ
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