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Molecular biological perspectives of the pharmacological modulation of the activation of professional phagocytes (MEB0810013)
Activation of tissue and blood phagocytes results in a production of reactive oxygen species during the oxidative stress. The response of professional phagocytes after their activation may be diminished by many drugs, natur...
FR - Farmakologie a lékárnická chemie
- 2010 - 2011 •
- 86 tis. Kč •
- 86 tis. Kč •
- MŠMT
Řešení projektu: 1. 1. 2010 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
The role of serotonin in mutual interactions of platelets and professional phagocytes (GA524/04/0897)
Accumulating evidence suggests that serotonin is a very important mediator of mutual interactions between platelets and professional phagocytes. However on the differentiation and oxidative burst of professional phagocy...
GJ - Choroby a škůdci zvířat, veterinární medicina
- 2004 - 2006 •
- 2 359 tis. Kč •
- 2 359 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2004 - 1. 1. 2006
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Antioxidative properties of flavonoids with respect to the oxidative burst of phagocytes and cooperation between phagocytes and endothelial cells (IAB6004204)
The major aim of the project is to test the hypothesis that flavonoids do affect the redox status of tissues also via regulating the differentiation, activation and function of professional phagocytes with respect to their cell-cell...
ED - Fyziologie
- 2002 - 2004 •
- 3 395 tis. Kč •
- 1 609 tis. Kč •
- AV ČR
Řešení projektu: 1. 1. 2002 - 1. 1. 2004
Uznané náklady
Podpora ze státního rozpočtu (47%)
Poskytovatel: Akademie věd České republiky
Effects of polyunsaturated fatty acids and their metabolites on the physiological functions of professional phagocytes (OC08058)
and nitrogen species (RONS) by resting and activated phagocytes, to investigate effects of phagocytes stimulated with compounds simulating bacterial or viral infection on the lipid phagocyte mediators with PUFAs during chr...
ED - Fyziologie
- 2008 - 2010 •
- 1 608 tis. Kč •
- 1 608 tis. Kč •
- MŠMT
Řešení projektu: 1. 1. 2008 - 31. 5. 2010
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
The influence of L-arginine and its analogues on the generation of reactive oxygen and nitrogen species by professional phagocytes (GA524/08/1753)
The aim of the project is to determine the effects of L-arginine and its analogues on the activity of NADPH oxidase, myeloperoxidase and inducible nitric oxide synthase. The activity of enzymes will be analysed in: i) ?chemical? system (pure enzymes)...
GJ - Choroby a škůdci zvířat, veterinární medicina
- 2008 - 2012 •
- 4 969 tis. Kč •
- 4 969 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2008 - 31. 12. 2012
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Interactions among collagen, platelets and phagocytes in modulation of reactive oxygen and nitrogen species production (OC10044)
to modulate the oxidative burst of phagocytes, production of reactive oxygen and nitrogen species by phagocytes and the extent of oxidative stress under pathological conditions species by phagocytes under physiological as ...
EC - Imunologie
- 2010 - 2011 •
- 742 tis. Kč •
- 742 tis. Kč •
- MŠMT
Řešení projektu: 1. 5. 2010 - 30. 6. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
New Role for Nitrated Fatty Acid in Modulation of Phagocyte-derived Inflammatory Responses (GP13-40824P)
-FAs to the phagocyte and endothelial cell alterations that are characteristic of phagocyte-derived inflammation and endothelial dysfunction related to these processes. Attention will be mainly directed toward how the NO2-FAs exert ...
EC - Imunologie
- 2013 - 2016 •
- 2 471 tis. Kč •
- 2 471 tis. Kč •
- GA ČR
Řešení projektu: 1. 2. 2013 - 24. 11. 2016
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Interactions between collagen, platelets and neutrophils with respect to wound healing (GA524/07/1511)
or not reactive oxygen and nitrogen species produced by professional phagocytes could modify that a phagocyte- derived oxidative stress could occur and participate in the pathophysiology, platelets and neutrophils cooperat...
EC - Imunologie
- 2007 - 2009 •
- 3 013 tis. Kč •
- 3 013 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2007 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Pnpt1 as a regulator of metabolic reprogramming in phagocytes (GA23-06536S)
Excessive activation of tissue resident phagocytes can lead to tissue damage and autoimmunity. It is known that the pathology is driven mainly by specific phagocyte, the underlying mechanisms controlling phagocyte metabolic...
Cell biology
- 2023 - 2025 •
- 9 913 tis. Kč •
- 9 913 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2023 - 31. 12. 2025
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The effects of histamine receptor H4R antagonists on the production of reactive oxygen and nitrogen metabolites by phagocytes (LD11010)
on haemopoietic cells including phagocytes. Whereas the effect of H1R antagonists on the production of phagocyte-derived RONM is relatively well described, the published studies about the relation of H4R with functional properties ...
EC - Imunologie
- 2011 - 2013 •
- 1 506 tis. Kč •
- 1 506 tis. Kč •
- MŠMT
Řešení projektu: 1. 3. 2011 - 30. 4. 2013
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
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