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Projects

17 projects (0,107s) •

Project

20alpha-hydroxy-metabolites of neuroactive pregnenolone isomers, progesterone and pregnenolone around parturition and the importace in physiology and diagnostics (NR9156)

The project investigates a possibility of influencing of the onset of parturition by changes in activity of 20alfa-hydroxysteroid dehydrogenase, which could contribute to the accelerating catabolism of progesterone and neuroinhibiting pregna...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2009
    • •
  • 7 161 tis. Kč
    • •
  • 5 883 tis. Kč
    • •
  • MZ
Project

Development of immunoassay RIA kits based on steroid histamine derivatives (FV20061)

The main aim of this project is a development of immunodiagnostic kits for determination of free testosterone, progesterone, aldosterone and cortisol. The main aim information subjected as secret) 2. (2018). - Progesterone derivati...

CE - Biochemie

  • 2017 - 2020
    • •
  • 12 874 tis. Kč
    • •
  • 7 359 tis. Kč
    • •
  • MPO
Project

Changes in the profile of steroids and their neuroactive metabolites in relation to prediction of term (NS9834)

The parturition is a multi-factorial process. A trigger mechanism that could be associated with the induction of parturition could be the changes of progesterone levels and, in human, particularly the changes of progesterone neuroac...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2008 - 2011
    • •
  • 5 646 tis. Kč
    • •
  • 5 646 tis. Kč
    • •
  • MZ
Project

Neuroactive steriods and initiation of parturition in human (GA303/04/1086)

of positive feedback loops involving corticoids prostaglandins and cytokines (progesterone and prostaglandin synthesis. The effect of 5beta-reduced progesterone metabolites should be also......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 4 028 tis. Kč
    • •
  • 3 952 tis. Kč
    • •
  • GA ČR
Project

The role of oxidoreductases in the regulation of tissue-specific effect of steroids in birds (IAA6011201)

and progesterone signals in birds. Four specific aims are proposed: (1) metabolismof flucocorticosteroids and progesterone and its distribution i nthe intestine, oviduct, and brain, (2......

ED - Fyziologie

  • 2002 - 2006
    • •
  • 2 673 tis. Kč
    • •
  • 2 141 tis. Kč
    • •
  • AV ČR
Project

Neuroendocrine and neurophysiological changes in patients after brain injury. (IZ4207)

We will follow the levels of LH, FSH, PRL, E2, testosterone, dihydrotestosterone, cortisol, TSH, fT4, progesterone and its brain metabolite, pregnanolone and its relationship to brainedema evolution in patients after brain contusion. We will...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1997 - 1999
    • •
  • 1 787 tis. Kč
    • •
  • 1 461 tis. Kč
    • •
  • MZ
Project

Occurrence and fate of synthetic progestins in aquatic environment and their effect on fish (GJ16-09709Y)

The aim of the project is to investigate occurrence and fate of synthetic progestins and progesterone in aquatic environment of some European countries. At the same time progestagenic activity of collected samples analysed by in vitro bioass...

DN - Vliv životního prostředí na zdraví

  • 2016 - 2018
    • •
  • 5 795 tis. Kč
    • •
  • 5 795 tis. Kč
    • •
  • GA ČR
Project

Influence of smoking and its cessation on endocrine system (NR9055)

In common steroids, the effect of smoking was investigated but in neuroactive steroids there are a nuber of metabolic pathawas that were not examined. Nicotine metabolites inhibit 3alpha-hydroxysteroid oxidoreductase, which is the enzyme participatin...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2006 - 2009
    • •
  • 6 948 tis. Kč
    • •
  • 6 380 tis. Kč
    • •
  • MZ
Project

Development of biotechnological methods and improvement of porcine reproduction level (EP7157)

progesterone shock). Hormonal therapy, agents harmonizing activity of the organism...

GG - Chov hospodářských zvířat

  • 1997 - 2000
    • •
  • 4 280 tis. Kč
    • •
  • 2 870 tis. Kč
    • •
  • MZe
Project

Evolutionary psychology aspects of couple hierarchy disparity (GPP407/12/P616)

by hormonal changes we will compare levels of salivary testosterone, progesterone...

FL - Psychiatrie, sexuologie

  • 2012 - 2014
    • •
  • 894 tis. Kč
    • •
  • 894 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 17