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Projects

38 projects (0,097s) •

Project

Selective inhibition of the babesial proteasome (GA17-14631S)

specificity profiling of catalytic units of the Plasmodium falciparum proteasome enabled the babesial 20S proteasome substrate preferences and compare them to the preferences 20S proteasome catalytic subunits. Furthermore,...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2017 - 2021
    • •
  • 6 898 tis. Kč
    • •
  • 5 959 tis. Kč
    • •
  • GA ČR
Project

Pseudopeptide proteasome inhibitors (GA18-03847S)

. Some proteasome inhibitors have been validated as drugs for the treatment further development. Our preliminary experiments identified new proteasomal inhibitors to the proteasome inhibitor and clinically used anticancer d...

Medicinal chemistry

  • 2018 - 2022
    • •
  • 7 637 tis. Kč
    • •
  • 6 680 tis. Kč
    • •
  • GA ČR
Project

Involvement of nuclear Vinculin in ubiquitin relay of proteasomes during early meiotic events. (GA18-19714S)

-proteasome system (UPS) is a key regulators of cellular proteostasis. It is implicated in prophase I nuclei revealed the prominent part of the proteasome regulation part as well and their direction to the proteasome during...

Cell biology

  • 2018 - 2022
    • •
  • 9 515 tis. Kč
    • •
  • 8 543 tis. Kč
    • •
  • GA ČR
Project

Identification and functional validation of proteasome mutations in multiple myeloma patients resistant to therapy with proteomal inhibitors (8E18B035)

generation sequencing panel enriched for genes that confer resistance to proteasomal expecting to reveal new molecular mechanisms of the resistance to proteasomal inhibitors) Identification of proteasome mutations in patie...

Hematology

  • 2018 - 2020
    • •
  • 2 028 tis. Kč
    • •
  • 978 tis. Kč
    • •
  • MŠMT
Project

The possibilities to affect the negative protein balance in severe illness - the effect of proteasome inhibitors (GA303/03/1512)

demonstrates, that the stimulation of ubiquitin-proteasome system is the main cause information concerning the effect of proteasome inhibitors on protein and amino acid. Specific aims of the project are a) to select the suitable

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
    • •
  • 2 862 tis. Kč
    • •
  • 2 862 tis. Kč
    • •
  • GA ČR
Project

Role of yeast Mmi1 in autophagy of protein aggregates, proteasomes and mitochondria (8J20AT023)

aggregates, ii) autophagy of inactive proteasomes and iii) autophagy of mitochondria. We for autophagy of protein aggregates and proteasomes, and the negative regulator of mitophagy......

Microbiology

  • 2020 - 2022
    • •
  • 83 tis. Kč
    • •
  • 83 tis. Kč
    • •
  • MŠMT
Project

Targeted protein degradation in plant hormone cytokinin responses (7AMB17AT027)

-wide analysis of the effects of disturbance in proteasome-dependent signaling lines with disrupted proteasome or cytokinin homeostasis. We will focus our work-proteasome cascade and/or manipulating cytokinin signaling, the...

CE - Biochemie

  • 2017 - 2018
    • •
  • 175 tis. Kč
    • •
  • 175 tis. Kč
    • •
  • MŠMT
Project

Clinically relevant substrates of proteasome degradation in MDS. (NU21-08-00312)

category represents MDS with deletion of chromosome 5q. A prototype of proteasome (AZA). The mechanism how proteasome inhibitors function as oncotherapy involves resistance towards proteasome inhibitors?......

Biochemistry and molecular biology

  • 2021 - 2024
    • •
  • 12 919 tis. Kč
    • •
  • 12 919 tis. Kč
    • •
  • MZ
Project

Influence of dithiocarbamate complexes with Pt(II) and Au(III) on NF-?B pathway in human tumor lines HepG2 and SK-HEP-1 (GP303/08/P137)

and proteasome. Compounds will be tested in two human tumor lines (HepG2 and SK-HEP-1...

FD - Onkologie a hematologie

  • 2008 - 2010
    • •
  • 1 414 tis. Kč
    • •
  • 1 414 tis. Kč
    • •
  • GA ČR
Project

Novel chemotherapy for piroplasmosis based on both repurposed and newly tailored inhibitors of essential proteolytic enzymes of Babesia parasites. (LUC24047)

The aim of the project is to prepare recombinant proteases BdASP3 and active 20S proteasome of Babesia divergens using optimized expression systems and to test their enzymatic activity. In the second phase, biochemical characterisation of th...

Microbiology

  • 2024 - 2026
    • •
  • 4 056 tis. Kč
    • •
  • 4 056 tis. Kč
    • •
  • MŠMT
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