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3 010 (0,057s) •

Project

Effect of protein hydration shell on the stability of protein complexes. (GPP205/12/P729)

Protein-protein interactions are at the basis of almost all cellular processes, but plays an active part in determining the structure and dynamics of both proteins and protein complexes. However, the exact molecula...

CF - Fyzikální chemie a teoretická chemie

  • 2012 - 2017
    • •
  • 2 037 tis. Kč
    • •
  • 2 037 tis. Kč
    • •
  • GA ČR
Project

Study of the interaction between 14-3-3 protein and regulator of G protein signaling RGS3. (IAA501110801)

protein?dependent regulation of function of RGS3 protein. 14-3-3 proteins are regulatory molecules that bind to other proteins in a phosphorylation dependent manner. RGS proteins function both as GTPase a...

BO - Biofyzika

  • 2008 - 2012
    • •
  • 5 095 tis. Kč
    • •
  • 5 095 tis. Kč
    • •
  • AV ČR
Project

Molecular basis of the 14-3-3 protein-dependent regulation of protein kinase activity (GA19-00121S)

14-3-3 proteins, a family of highly conserved dimeric proteins ubiquitously proteins including many disease-relevant protein kinases. However, our understanding of how the 14-3-3 proteins regulate the acti...

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 8 340 tis. Kč
    • •
  • 8 034 tis. Kč
    • •
  • GA ČR
Project

Study of WD-protein function in actinomycetes (IAA5020207)

Proteins with WD40 motif are directly involved in signal transduction and transport. The function of WD40 repeats themselves in particular proteins, insofar as their function is known, consists in protein-protein i...

EB - Genetika a molekulární biologie

  • 2002 - 2005
    • •
  • 3 839 tis. Kč
    • •
  • 3 186 tis. Kč
    • •
  • AV ČR
Project

New tools of label-free electrochemical analysis of protein interactions with nucleic acids and proteins (GA18-18154S)

that can contribute by new insights about complex protein systems. We wish to take advantage of electrochemical approaches to design new tools for the analysis of protein in the Applicant laboratory, showing that particularly all <...

Biophysics

  • 2018 - 2021
    • •
  • 3 613 tis. Kč
    • •
  • 3 433 tis. Kč
    • •
  • GA ČR
Project

Molecular studies on the structure of the heteromeric GABA-B receptors (NF6704)

The aim of our studies is to map portions of the BR1 and BR2 proteins that are in close proximity and contribute to the protein-protein interactions that are involvolved in the structural formation of the functional GABA-B ...

FE - Ostatní obory vnitřního lékařství

  • 2001 - 2003
    • •
  • 1 849 tis. Kč
    • •
  • 1 723 tis. Kč
    • •
  • MZ
Project

Occurence of WD repeat proteins in prokaryotic cells and their possible role in a new type of regulation of gene expression in prokaryotes (GA204/96/1262)

The WD-repeat proteins carrying 4-8 repeats of conserved amino acid motif have been found to be regulatory proteins in eukaryotes. None is an enzyme. The WD-repeats play a role in protein-protein interaction. Up to...

EE - Mikrobiologie, virologie

  • 1996 - 1998
    • •
  • 2 038 tis. Kč
    • •
  • 1 624 tis. Kč
    • •
  • GA ČR
Project

Regulatory mechanism of kinase activity of protein kinase ASK1 (GA14-10061S)

The main goal of this project is to study the role of the 14-3-3 proteins in the regulation of the kinase activity of the catalytic domain of protein kinase ASK1 (Apoptosis signal-regulating kinase 1). The 14-3-3 protein bi...

CE - Biochemie

  • 2014 - 2016
    • •
  • 5 937 tis. Kč
    • •
  • 5 937 tis. Kč
    • •
  • GA ČR
Project

Interaction proteins with surfaces. New biophysical methods for analysis of tumor supressos protein p53 (GP202/07/P497)

The tumor suppressor protein plays a critical role in the control of cell suppressor function of the p53 protein and enhance the metastatic potential. Point. At present time new methods are sought suitable for analysis of protei...

BO - Biofyzika

  • 2007 - 2009
    • •
  • 1 164 tis. Kč
    • •
  • 1 164 tis. Kč
    • •
  • GA ČR
Project

Investigation of molecular architecture and molecular interactions of biologically important proteins and their protein domains (VS96141)

of the current project is the preparation of key protein components from selected biological, molecular genetics, recombinant expression of proteins, protein and peptide mass spectrometry These studies will be performed on...

EA - Morfologické obory a cytologie

  • 1996 - 2000
    • •
  • 36 562 tis. Kč
    • •
  • 30 374 tis. Kč
    • •
  • MŠMT
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