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3 410 (0,115s) •

Project

Role of yeast Mmi1 in autophagy of protein aggregates, proteasomes and mitochondria (8J20AT023)

for autophagy of protein aggregates and proteasomes, and the negative regulator of mitophagy homeostasis and survival under stress conditions. Yeast protein Mmi1 is an ortholog of the mammalian “translationally controlled ...

Microbiology

  • 2020 - 2022
    • •
  • 83 tis. Kč
    • •
  • 83 tis. Kč
    • •
  • MŠMT
Project

Interfacial properties of alpha-synuclein and aggregation of this protein in Parkinson's disease (KJB100040901)

and deposition of amyloid fibrils of the protein alpha-synuclein (AS). Studies of AS aggregation invitro are associated with hopes for better understanding, diagnosing of AS aggregation and particularly of formation of the...

BO - Biofyzika

  • 2009 - 2011
    • •
  • 1 620 tis. Kč
    • •
  • 1 620 tis. Kč
    • •
  • AV ČR
Project

New imaging and spectroscopic methods for biological studies (8J20PL040)

and imaging procedures for chiral biomolecules such as protein fibrils, nucleic acid, supramolecular assemblies, and carotenoid aggregates. We will broaden the existing and spectral response of protein amyloid fibrils. Thi...

Biophysics

  • 2020 - 2022
    • •
  • 141 tis. Kč
    • •
  • 141 tis. Kč
    • •
  • MŠMT
Project

A Microfluidic Platform for Investigating the Mechanism of Action of Alzheimer's Drug Candidates (GF25-15784L)

Protein aggregation lies at the root of Alzheimer's disease, as well as other of aggregation and amyloid formation is a promising concept for the development of disease protein reconstitution aiming to develop on-c...

Biophysics

  • 2025 - 2027
    • •
  • 9 906 tis. Kč
    • •
  • 9 906 tis. Kč
    • •
  • GA ČR
Project

Protein and DNA-modified electrodes. New tools for biomedicine (GA301/07/0490)

of early changes preceding aggregation of amyloidogenic proteins involved in the mutated proteins caused to single amino acid exchange. The ability of thiolated signals will be utilized in the development of sensors for DN...

CE - Biochemie

  • 2007 - 2009
    • •
  • 3 395 tis. Kč
    • •
  • 3 395 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of the reactive oxygen species induced damage to proteins of the photosystem II complex (GA203/00/1257)

types of the protein photodamage can be distinguished: (1) modification, reflected by the shift of the protein electrophoretic mobility; (2) adduct formation and (3) aggregation, typical by crosslinking of two (adduct) or ...

CE - Biochemie

  • 2000 - 2002
    • •
  • 1 520 tis. Kč
    • •
  • 1 375 tis. Kč
    • •
  • GA ČR
Project

Label-free super-resolution microscopy based on single-protein fluctuations to study the assembly of tau protein envelopes (GA23-07703S)

in the observation of assembling protein structures hinders our understanding of some of the key processes including the earliest stages of the tau aggregate formation. To capture the mechanisms of tau aggregates formation...

Cell biology

  • 2023 - 2025
    • •
  • 9 981 tis. Kč
    • •
  • 9 981 tis. Kč
    • •
  • GA ČR
Project

Combinatorial approach to myelin and/or beta-sheet breakers. Implication for the therapeutic approaches to Alzheiner's and prion diseases (GA203/02/1379)

fragment fromhuman prion protein (HuPrP106-26) which is able of the aggregation similarly to prion proteins in sick organisms. In the biological and physico-chemical interaction of HuPrP106-26 with DNA (which is aggreg...

CC - Organická chemie

  • 2002 - 2004
    • •
  • 1 840 tis. Kč
    • •
  • 1 327 tis. Kč
    • •
  • GA ČR
Project

Identification and RNAi silencing of aggregation pheromone production genes in the spruce-killing bark beetles (Ips typographus) (GA23-07916S)

is coordinated by the male-produced aggregation pheromone containing 2-methyl-3-buten-2-ol the stability of respective proteins, the pheromone production in beetles will be induced by juvenile hormone. Changes in metabolites, RNA-t...

Biochemistry and molecular biology

  • 2023 - 2025
    • •
  • 6 338 tis. Kč
    • •
  • 6 338 tis. Kč
    • •
  • GA ČR
Project

Development of Chiral Spectroscopic Methods for Intermolecular Interaction Studies (GA20-10144S)

, such as molecular aggregates and chiral liquids. In the project, we focus on three application areas, amyloidal protein aggregates present during neurodegenerative diseases, low......

Physical chemistry

  • 2020 - 2022
    • •
  • 7 447 tis. Kč
    • •
  • 6 210 tis. Kč
    • •
  • GA ČR
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