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3 060 (0,115s) •

Project

Enzyme hydration and flexibility studied by advanced structural and biophysical methods (GA17-24321S)

An integrated view of protein structure, solvation, dynamics, and function is emerging where internal protein motions are closely linked to enzyme catalysis. The main objective of this project is to investigate connection between hy...

CE - Biochemie

  • 2017 - 2019
    • •
  • 9 834 tis. Kč
    • •
  • 9 578 tis. Kč
    • •
  • GA ČR
Project

Study of the interaction between 14-3-3 protein and regulator of G protein signaling RGS3. (IAA501110801)

protein?dependent regulation of function of RGS3 protein. 14-3-3 proteins are regulatory molecules that bind to other proteins in a phosphorylation dependent manner. RGS proteins function both as GTPase a...

BO - Biofyzika

  • 2008 - 2012
    • •
  • 5 095 tis. Kč
    • •
  • 5 095 tis. Kč
    • •
  • AV ČR
Project

Self-organization, crystallization and structure determination of protein based macromolecular systems (IAA500500701)

Persistent problem of the protein crystallography is low efficiency protein complexes showed high efficacy. They often proved to bind partly at specific siteson the protein surface and partly they remain solvated i...

CE - Biochemie

  • 2007 - 2011
    • •
  • 2 786 tis. Kč
    • •
  • 2 786 tis. Kč
    • •
  • AV ČR
Project

Role of the 14-3-3 protein in the regulation of phosducin function (GAP305/11/0708)

ultracentrifugation and protein crystallography will be used as principal tools. PhosducinThe main goal is to study the structural basis for the 14-3-3 protein-dependent and Ser73 and the binding to the regulatory 14-3-3 <...

EB - Genetika a molekulární biologie

  • 2011 - 2015
    • •
  • 6 340 tis. Kč
    • •
  • 6 340 tis. Kč
    • •
  • GA ČR
Project

Molecular interactions of polymers for biomedical applications (GA305/07/1073)

, no attempt was noticed to use protein crystallography probably due to the wide spread advances of protein crystallography. New methods of  sample preparation and new mathematical procedures now allow direct exper...

CD - Makromolekulární chemie

  • 2007 - 2011
    • •
  • 3 136 tis. Kč
    • •
  • 3 136 tis. Kč
    • •
  • GA ČR
Project

Vývoj metod pro studium struktury farmakologicky aktivních enzymů (8X17050)

expertise and resources in structural bioinformatics (Serbia), protein crystallization. X-ray crystallography provides details of interatomic interactions necessary for understanding protein function and rational design o...

BO - Biofyzika

  • 2017 - 2018
    • •
  • 110 tis. Kč
    • •
  • 110 tis. Kč
    • •
  • MŠMT
Project

Structure analysis of complexes of HIV protease with selected ligands (GA204/00/P091)

The methodology of protein crystallography - the method for experimental. The aim of this project is to verify precision and correctness of the protein crystallography results and to recommend optimal procedures fo...

CF - Fyzikální chemie a teoretická chemie

  • 2000 - 2002
    • •
  • 806 tis. Kč
    • •
  • 599 tis. Kč
    • •
  • GA ČR
Project

Automac interpretation of electron density maps for structure genomics (GA204/06/1007)

The aim of this project is development of an automatic expert system and a computer program for electron density map interpretation and for automatic model building in the protein and nucleic acids crystallography. Such a system is ...

FR - Farmakologie a lékárnická chemie

  • 2006 - 2008
    • •
  • 695 tis. Kč
    • •
  • 695 tis. Kč
    • •
  • GA ČR
Project

Structural biology using new generation X-ray sources (8J23FR035)

and transform projects beyond classical "static" crystallography. It will open up a unique opportunity to get a practical insight into serial crystallography......

Biophysics

  • 2023 - 2024
    • •
  • 156 tis. Kč
    • •
  • 156 tis. Kč
    • •
  • MŠMT
Project

Novel flavin-dependent enzymes of Paracoccus denitrificans reaction mechanisms, metabolic functions and their role in cellular oxidative stress (GAP503/12/0369)

for the FerA will be isolated and the prepared corresponding recombinant protein will be characterized enzymologically, by X-ray crystallography and by site-directed mutagenesis. It will be determined whether FerA acts alone or in ...

CE - Biochemie

  • 2012 - 2017
    • •
  • 4 924 tis. Kč
    • •
  • 4 924 tis. Kč
    • •
  • GA ČR
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