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5 105 (0,1s) •

Project

Stabilization of commercially-relevant FGF proteins using advanced automated methods of protein engineering (FW03010208)

of protein engineering. This project is focused on development of stable proteins FGF4 of the native forms of these proteins complicates and often prevents their practical use in research and medicine. FGF stabili...

Health-related biotechnology

  • 2021 - 2024
    • •
  • 24 890 tis. Kč
    • •
  • 17 410 tis. Kč
    • •
  • TA ČR
Project

Engineering radionuclide - labeled antibodies (OE 210)

production of prototype radioimunological agent based on protein-engineered antibody with required combination of desirable properties......

EC - Imunologie

  • 2006 - 2009
    • •
  • 18 186 tis. Kč
    • •
  • 9 093 tis. Kč
    • •
  • MŠMT
Project

Nové koncepty a nástroje pro racionální design enzymů (LH14027)

-year project will be a new concept engineered proteins, mutant proteinsThe project aims to develop a new concept for the rational engineering modelling of energetically favored protein conformations which...

CE - Biochemie

  • 2014 - 2016
    • •
  • 1 943 tis. Kč
    • •
  • 1 943 tis. Kč
    • •
  • MŠMT
Project

Rational re-design of microbial enzymes involved in degradation of toxic organic pollutants. (ME 276)

aliphatic hydrocarbons. The structures of the proteins from the family of haloalkane dehalogenases will be rationaly modified using the methods of genetic engineering. The impact of the changes in proteins structure on act...

EB - Genetika a molekulární biologie

  • 1998 - 2002
    • •
  • 3 260 tis. Kč
    • •
  • 1 160 tis. Kč
    • •
  • MŠMT
Project

Construction of a synthetic metabolic pathway for degradation of important environmental pollutant using protein and metabolic engineering (GAP503/12/0572)

by cloning the genes optimized by protein engineering to native bacteria, leading of a microorganism constructed by protein and matabolic engineering, applicable for the cleanup......

DJ - Znečištění a kontrola vody

  • 2012 - 2016
    • •
  • 8 980 tis. Kč
    • •
  • 8 980 tis. Kč
    • •
  • GA ČR
Project

Production of stable fibroblast growth factors for research, therapeutic and cosmetic applications (TH02010219)

The aim of the project is to remove low stability of fibroblast growth factors (FGFs) that prevents their practical use. FGFs are proteins that promote cell efficiency and increases the cost of final products. In the project, advanced pr...

EI - Biotechnologie a bionika

  • 2017 - 2020
    • •
  • 20 364 tis. Kč
    • •
  • 12 186 tis. Kč
    • •
  • TA ČR
Project

Structure, function, substrate specificity and inhibition of retroviral proteinases protein engineering study of retroviral processing (IA455102)

CE - Biochemie

  • 1993 - 1994
    • •
  • 0 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • AV ČR
Project

Exploring the acquisition of novel protein functions within haloalkane dehalogenase family (GA22-09853S)

systems and can be given non-natural catalytic functions by protein engineering-underexplored protein elements – flexible loops and access tunnels – play a pivotal role protein and catalytic functions. The gained ...

Arts, Art history

  • 2022 - 2024
    • •
  • 13 757 tis. Kč
    • •
  • 13 677 tis. Kč
    • •
  • GA ČR
Project

Resolving the puzzle of resonance energy transfer in bioluminescence (GX25-17329X)

excitation energy from a luminescent protein donor to a fluorescent protein acceptor, has this significance, key questions remain unanswered: how do proteins physically interact approach. We aim to reveal molecular details...

Biochemistry and molecular biology

  • 2025 - 2029
    • •
  • 49 906 tis. Kč
    • •
  • 49 906 tis. Kč
    • •
  • GA ČR
Project

CETOCOEN UPgrade (ED2.1.00/19.0382)

(extension of (i) research program of protein engineering) 3b) detailed microscopic (extension of (i) research program of protein engineering) 4a) researchof new biomarkers on environmental chemistry and modeling,...

DA - Hydrologie a limnologie

  • 2015 - 2015
    • •
  • 26 809 tis. Kč
    • •
  • 4 021 tis. Kč
    • •
  • MŠMT
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