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3 067 (0,144s) •

Project

The chaperones and stress factors effect on folding and stability of the wild type and mutant cystathionine beta-synthase (CBS) (GP305/02/D167)

of given protein in a cell. The fate of the mutant proteins is result of competition between folding, aggregation and degradation of given protein. The aim of this project isto study protein folding

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 580 tis. Kč
    • •
  • 580 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanism of protein translocation through the bacterial Type I secretion system (GA15-11851S)

) proteins characterized by the C-terminal calcium-binding repeats. We shall investigate the structure-function relationships underlying the folding of RTX repeats and their role insight into molecular basis of a calcium-dependent <...

EE - Mikrobiologie, virologie

  • 2015 - 2017
    • •
  • 7 053 tis. Kč
    • •
  • 7 053 tis. Kč
    • •
  • GA ČR
Project

Fundamental Principles of Protein Folding and Protein-Ligand Interactions Revealed by High-Level Quantum Chemical Calculations (GA20-08772S)

in protein structure, design, and protein-ligand interactions. Specifically, we will map and study the so-called protein frustration (strain) of the peptide fragments within the context of the protein. We will com...

Physical chemistry

  • 2020 - 2022
    • •
  • 8 433 tis. Kč
    • •
  • 6 555 tis. Kč
    • •
  • GA ČR
Project

Characterization of protein homeostasis mechanisms and their abnormalities in human cancer (GA16-07321S)

demands on folding of unstable oncogenic proteins, increased proteosynthesis will analyse 1) Hsp70/ Hsp90 complexes and their client proteins; 2) translation-stress protein homeostasis pathways.......

FD - Onkologie a hematologie

  • 2016 - 2018
    • •
  • 4 863 tis. Kč
    • •
  • 4 479 tis. Kč
    • •
  • GA ČR
Project

The role of the chaperone system in malignant transformation and response to anti-cancer therapy (GAP301/11/1678)

activities of chaperones that act to ensure correct folding of proteins in deciding whether a protein is targeted for folding or degradation is unclear suppressor protein is regulated by the Hsp70/Hsp90 s...

FD - Onkologie a hematologie

  • 2011 - 2015
    • •
  • 9 187 tis. Kč
    • •
  • 9 187 tis. Kč
    • •
  • GA ČR
Project

Structural and functional analysis of Hsp70/Hsp90 chaperone complexes. (GA16-20860S)

reveal new factors influencing the activity of Hsp70 and Hsp90, uncover new protein be exploited in biotechnology industry including rational drug design or folding of recombinant proteins.......

CE - Biochemie

  • 2016 - 2020
    • •
  • 7 015 tis. Kč
    • •
  • 6 571 tis. Kč
    • •
  • GA ČR
Project

Molecular and cellular consequences of p53 manipulation using heat shock protein inhibitors and E3-ligases. (GA301/08/1468)

circumstances. Many p53 mutant proteins found in human tumours are stabilised compared ligases in their folding and stabilisation. We will accompany our study with functional and stability analyses of these proteins, with ...

FD - Onkologie a hematologie

  • 2008 - 2010
    • •
  • 3 063 tis. Kč
    • •
  • 2 925 tis. Kč
    • •
  • GA ČR
Project

Development of theoretical and spectroscopic tools for studies of amyloid fibrils (GA15-09072S)

, the knowledge about protein folding will contribute to the diagnostics and treatment of protein misfolding diseases. Three senior researchers and two PhD studentsPeptide and protein fibrils have been attracting c...

BO - Biofyzika

  • 2015 - 2017
    • •
  • 3 616 tis. Kč
    • •
  • 3 616 tis. Kč
    • •
  • GA ČR
Project

Exploring Conformational Space of Short Peptides by Advanced Quantum Chemical and Solvation Methods A Key to Understand Protein Structures? (GA17-24155S)

the variability of this space and protein folding. This involves development and calibration with the existing folds in proteins which may ultimately answer the fundamental question: ”How much of the protein

CF - Fyzikální chemie a teoretická chemie

  • 2017 - 2019
    • •
  • 5 100 tis. Kč
    • •
  • 3 531 tis. Kč
    • •
  • GA ČR
Project

Biological code of knots – identification of knotted patterns in biomolecules via AI approach (GF23-04260L)

The goal of this project is to understand the knotting phenomena in proteins based on Artificial Intelligence (AI) approach, and to develop means to predict de novo knotted protein structures. The scope of the project belongs to the...

Biophysics

  • 2023 - 2025
    • •
  • 4 137 tis. Kč
    • •
  • 4 137 tis. Kč
    • •
  • GA ČR
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