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12 639 (0,169s) •

Project

Structure-function relationship of protein (GP204/01/P055)

The proposed method for the study of structure-function relations of proteins is based on an integration of information available on protein structure, given structure and function of proteins are...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 325 tis. Kč
    • •
  • 325 tis. Kč
    • •
  • GA ČR
Project

Structure-function relationships underlying protein-protein interactions (GAP305/10/2184)

Under this proposal molecular and structural biologists joined forces with computational chemists to unravel some fundamental principles underlying protein-protein interactions. In a case study building on several available...

EB - Genetika a molekulární biologie

  • 2010 - 2014
    • •
  • 8 276 tis. Kč
    • •
  • 8 276 tis. Kč
    • •
  • GA ČR
Project

Molecular studies on the structure of the heteromeric GABA-B receptors (NF6704)

The aim of our studies is to map portions of the BR1 and BR2 proteins that are in close proximity and contribute to the protein-protein interactions that are involvolved in the structural formation of the functiona...

FE - Ostatní obory vnitřního lékařství

  • 2001 - 2003
    • •
  • 1 849 tis. Kč
    • •
  • 1 723 tis. Kč
    • •
  • MZ
Project

Effect of protein hydration shell on the stability of protein complexes. (GPP205/12/P729)

, but plays an active part in determining the structure and dynamics of both proteins and protein complexes. However, the exact molecular details of water contribution, water molecule behavior at the protein surfac...

CF - Fyzikální chemie a teoretická chemie

  • 2012 - 2017
    • •
  • 2 037 tis. Kč
    • •
  • 2 037 tis. Kč
    • •
  • GA ČR
Project

Structural insight into E. coli protein WrbA, the founding member of a family of proteins implicated in defense of cells against oxidative stress (GAP207/10/1934)

for understanding structure and function in these proteins. The biochemical and biophysicalThe objective of the proposed work is to provide biochemical and structural in sight into the functions of the E. coli protein<...

BO - Biofyzika

  • 2010 - 2016
    • •
  • 6 081 tis. Kč
    • •
  • 6 081 tis. Kč
    • •
  • GA ČR
Project

New approaches for study of protein structure by means of vibrational spectroscopy (KJB101120805)

Determination of the protein structure represents one of the key tasks of present molecular biology. There is an urgent need for tree-dimensional structures of the secondary structures content of proteins ...

BO - Biofyzika

  • 2008 - 2010
    • •
  • 1 622 tis. Kč
    • •
  • 1 622 tis. Kč
    • •
  • AV ČR
Project

Stuctural study of new type of protein (WrbA),which is like flavodoxin. (ME 640)

Project is targeted on structural research of WrbA proteins....

BO - Biofyzika

  • 2003 - 2006
    • •
  • 1 135 tis. Kč
    • •
  • 785 tis. Kč
    • •
  • MŠMT
Project

Terrestrial protein sequence and structure space evolution (GJ17-10438Y)

protein structures/functions can be constructed. Diverse lines of evidence converge repertoire of protein structures. Two parallel approaches will be employed: (i) analysis of secondary structure motif fo...

CE - Biochemie

  • 2017 - 2021
    • •
  • 8 369 tis. Kč
    • •
  • 8 369 tis. Kč
    • •
  • GA ČR
Project

Fundamental Principles of Protein Folding and Protein-Ligand Interactions Revealed by High-Level Quantum Chemical Calculations (GA20-08772S)

information from structural database. We will apply them to answer fundamental questions in protein structure, design, and protein-ligand interactions. Specifically, we will map and study the so-called protein...

Physical chemistry

  • 2020 - 2022
    • •
  • 8 433 tis. Kč
    • •
  • 6 555 tis. Kč
    • •
  • GA ČR
Project

Mapping Accessible Surface Area of Soluble and Membrane Proteins by Employing Reactive Probes (GA25-18181S)

Structural proteomics is an emerging direction in structural biology. It covers targets amino acid side chains in the protein sequence so it provides complementary structural information. The original labeling app...

Analytical chemistry

  • 2025 - 2027
    • •
  • 6 606 tis. Kč
    • •
  • 6 606 tis. Kč
    • •
  • GA ČR
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