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8 047 (0,096s) •

Project

Triplex-forming DNA and its interactions with p53 proteins (GP204/06/P369)

in superhelical DNA (scDNA). Interaction of p53 with DNA involving the triplex structures will be applied. Particular attention will be aimed to the methodsdetectionof DNA-protein interaction and...

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 1 197 tis. Kč
    • •
  • 1 197 tis. Kč
    • •
  • GA ČR
Project

Protein-DNA Complexes and Force Field Development (GA20-28231S)

The aim of this proposal is to explore protein-DNA interactions hand in hand and we have indications that these problems may propagate to protein-DNA interactions. Because systematic studies of FF...

Physical chemistry

  • 2020 - 2022
    • •
  • 2 687 tis. Kč
    • •
  • 2 687 tis. Kč
    • •
  • GA ČR
Project

Interactions of p73 protein and its isoforms with DNA. Influences of DNA supercoiling, conformation and anticancer drugs (GP204/07/P476)

The p73 protein shares a remarkable homology with closely related protein p53 in development of an organism. The p73 proteins are able to induce p53-target genes (such as p21, mdm2, bax, etc.). This project is focused on st...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 1 056 tis. Kč
    • •
  • 1 056 tis. Kč
    • •
  • GA ČR
Project

Influence of conformation motifs and epigenetic modifications to DNA binding properties of p53 family proteins (GA15-21855S)

understand how protein-DNA interactions maybe regulated by post translational modifications and local DNA structures (cruciform, triplexes and quadruplexes) on protein-DNA interaction. W...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 6 795 tis. Kč
    • •
  • 6 795 tis. Kč
    • •
  • GA ČR
Project

Analysis of the interactions of mutagens, carcinogens and anti-cancer drugs with biopolymers by means of electrochemical and biochemical methods. (IAA4004901)

with proteins (including DNA covalent adduct-specific antibodies, enzymes and protein p53 with mercury abd solid electrodes in studies of covalent and/or non-covalent interactions of nucleic acids (NA) and pro...

CE - Biochemie

  • 1999 - 2001
    • •
  • 2 422 tis. Kč
    • •
  • 827 tis. Kč
    • •
  • AV ČR
Project

Interactions of wild type and mutant p53 proteins with damaged DNA and their roles in cellular response to anticancer chemotherapy (IAA500040701)

Interactions of tumor suppressor protein p53 with DNA are crucial for its and molecular-biologicaltechniques, interactions of purified proteins with DNA in cell-free and mut p53 interactions

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 824 tis. Kč
    • •
  • 4 824 tis. Kč
    • •
  • AV ČR
Project

Interactions of supercoiled DNA with tumor-supressor protein p53 (IAA5004803)

interactions with DNA understanding of which we feel to be essential for rationalizing how this key protein exerts its multiple functions in the cell. The contemplated studies will be directed at: a) the influence of the <...

EB - Genetika a molekulární biologie

  • 1998 - 2000
    • •
  • 2 899 tis. Kč
    • •
  • 990 tis. Kč
    • •
  • AV ČR
Project

Electrodes modified with nucleic acids and proteins.New tools in biochemical and biomedical research. (GV204/97/K084)

the interaction of DNA with specific proteins and anticancer drugs, etc. In addition the DNA-p53 protein interactions in human cancer will be obtained. The m and in the studies of interaction...

CE - Biochemie

  • 1997 - 2001
    • •
  • 36 964 tis. Kč
    • •
  • 19 597 tis. Kč
    • •
  • GA ČR
Project

Platinum Metal Complexes as DNA-Protein Cross-Linking Agents (ME08017)

This project is aimed to find out data on covalent interactions of DNA modified by platinum complexes with proteins....

BO - Biofyzika

  • 2008 - 2010
    • •
  • 2 226 tis. Kč
    • •
  • 2 226 tis. Kč
    • •
  • MŠMT
Project

Interactions of mutant p53 with genomic DNA in vitro and in vivo (1K04119)

for the detection of DNA-protein interactions, computer analysis of DNA structure, chemical and enzymatic probes, electrochemical analysis of DNA and proteins and techniques mutp53 DNA b...

EB - Genetika a molekulární biologie

  • 2004 - 2007
    • •
  • 2 672 tis. Kč
    • •
  • 2 420 tis. Kč
    • •
  • MŠMT
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