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7 (0,068s) •

Project

Phenotypic reversion of v- src- transformed mammalian cells- a model for the mechanism of the host cell- mediated regulation of the proviral expression (GA312/95/0583)

FD - Onkologie a hematologie

  • 1995 - 1997
    • •
  • 1 246 tis. Kč
    • •
  • 1 246 tis. Kč
    • •
  • GA ČR
Project

Overcoming the transcriptional inhibition of the Rous sarcoma virus in mammalian cells by the anti-methylation effects on the virus regulatory sequences (GA312/97/P082)

Rous sarcoma virus (RSV) integrated into the mammalian host genome is generally inactivated on the level of transcription of the proviral DNA. Basis, and cytosine methylation of proviral DNA. Our project is aimed to gain some knowle...

EE - Mikrobiologie, virologie

  • 1997 - 1999
    • •
  • 640 tis. Kč
    • •
  • 530 tis. Kč
    • •
  • GA ČR
Project

Pattern of DNA methylation in retroviral regulatory sequences (GA204/01/0632)

CpG methylation of proviral DNA is the key mechanism of transcriptional regulation of retroviruses by the host cell. We and others have obtained preliminary data that the sequence-specific pattern of methylation, i.e. the methylation status ...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 4 657 tis. Kč
    • •
  • 2 210 tis. Kč
    • •
  • GA ČR
Project

Epigenomics of retroviral integration (GA14-34873S)

and correlate the proviral expression with genomic/epigenomic parameters of the integration interest will be the proviral silencing during the integration process, where......

EB - Genetika a molekulární biologie

  • 2014 - 2018
    • •
  • 5 836 tis. Kč
    • •
  • 5 836 tis. Kč
    • •
  • GA ČR
Project

Development of CpG methylation of HIV-1 promoter and its stabilizing effect on the latent provirus reservoir longitudinal study in patients (GAP304/12/1736)

Existence of latent HIV-1 reservoir makes the eradication of HIV-1 infection unreal. DNA methylation of retroviral 5' long terminal repeat (LTR) is one of the mechanisms of latency maintenance. In our previous work we have shown that CpG methylation ...

EE - Mikrobiologie, virologie

  • 2012 - 2016
    • •
  • 3 885 tis. Kč
    • •
  • 3 885 tis. Kč
    • •
  • GA ČR
Project

Interactions betwen viral and host cell proteins from purification of macromolecular complexes to high-resolution structures (GESCO/06/E001)

of proviral DNA into the host genome, in targeting of retroviral polyproteins...

CE - Biochemie

  • 2006 - 2009
    • •
  • 4 500 tis. Kč
    • •
  • 4 500 tis. Kč
    • •
  • GA ČR
Project

V-src oncogenes the dominant players in a hierarchy of events leading to cancer (GA204/02/0407)

genome, of a proviral structure corresponding to v-src mRNA (LTR,v-src,LTR); viral...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 5 847 tis. Kč
    • •
  • 2 262 tis. Kč
    • •
  • GA ČR
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