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21 (0,057s) •

Project

Changes in the microbiome composition as a risk factor in the development of psoriasis (NV15-30782A)

Affecting 2-3% of population, psoriasis is a chronic, autoimmune skin disease for psoriasis induction and perpetuation. Our main goal is to find new markers associated with psoriasis that could be included in preventive med...

FO - Dermatovenerologie

  • 2015 - 2018
    • •
  • 6 426 tis. Kč
    • •
  • 6 426 tis. Kč
    • •
  • MZ
Project

Health risk level evaluation of Goeckerman`s therapy (UV-B and coal tar) of psoriasis in adults (NR8154)

PAU and UV-B represent mutagenic (carcinogenic) and immunotoxic environmental agents. Incidence of psoriasis is growing. Goeckerman`s therapy of psoriasis (GT) exposes patients to combined effect PAH and UV-B (often used as method o...

FM - Hygiena

  • 2004 - 2006
    • •
  • 1 203 tis. Kč
    • •
  • 1 203 tis. Kč
    • •
  • MZ
Project

New approaches to evaluation and prevention of toxicity of long-term pharmacotherapy of psoriasis with methotrexate pharmacokinetics and influences of the genetic polymorphism (NR7947)

New approaches to evaluation and prevention of toxicity of long-term pharmacotherapy of psoriasis with low-dose oral methotrexate. A prospective, randomized double blind study of methotrexate effect and toxicity. The study is conducted in tw...

FR - Farmakologie a lékárnická chemie

  • 2004 - 2006
    • •
  • 1 482 tis. Kč
    • •
  • 1 431 tis. Kč
    • •
  • MZ
Project

The impact of psoriasis on the guality of life in the Czech Republic - comparison with the results in other countries (pilot study) (NK7727)

for the successfallmanagament of psoriasis a good compliance of the patient is necessary....

FO - Dermatovenerologie

  • 2003 - 2005
    • •
  • 919 tis. Kč
    • •
  • 897 tis. Kč
    • •
  • MZ
Project

Risk factors of comorbidities of Psoriasis usable in secondary prevention (NT13275)

Psoriasis is a chronic inflammatory skin disease with prevalence in population 2-3 %. Psoriasis is associated with other disorders like arthropathy, chronic inflammatory bowel diseases (Crohn disease, ulcerative colitis, coeliac dis...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2012 - 2015
    • •
  • 4 210 tis. Kč
    • •
  • 4 210 tis. Kč
    • •
  • MZ
Project

Personalized medicine approach based on analysis of immunity and microbiota interactions as a tool to predict therapeutic response in patients with psoriasis (NW24-06-00509)

Psoriasis is a chronic, systemic immune-mediated disease with complex, is of crucial importance for psoriasis development, where aberrant immune response of patients with psoriasis with established clinical (e.g. BMI) and m...

Dermatology and venereal diseases

  • 2024 - 2027
    • •
  • 11 273 tis. Kč
    • •
  • 11 273 tis. Kč
    • •
  • MZ
Project

(psoriatic and rheumatoid arthritis) and psoriasis vulgaris (NS10618)

1. The study of mRNA immune cells expression (CD14 cells ) in patiens suffering from SLE, rheumatoid arthritis, psoriatic arthritis, psoriasis vulgaris and kontrol group 2. To complete the immunogenetic study with the SLE, RA, PV and PsA ris...

FE - Ostatní obory vnitřního lékařství

  • 2009 - 2011
    • •
  • 4 447 tis. Kč
    • •
  • 4 447 tis. Kč
    • •
  • MZ
Project

Effect and pharmacokinetics of methotrexate in the treatment of psoriasis (IZ2960)

FR - Farmakologie a lékárnická chemie

  • 1995 - 1997
    • •
  • 1 473 tis. Kč
    • •
  • 1 373 tis. Kč
    • •
  • MZ
Project

Immunomodulatory ligands targeted to IL-23/Th17 pro-inflammatory axis as novel tools for development of topical drugs for treatment of psoriasis (NV16-27676A)

Psoriasis, an incurable chronic autoimmune skin disease affecting more than 100 milion population worldwide, has recently been closely associated with the role of Th17 cells. Differentiation of Th0 naive cells into the mature Th17 population...

FO - Dermatovenerologie

  • 2016 - 2019
    • •
  • 11 624 tis. Kč
    • •
  • 10 596 tis. Kč
    • •
  • MZ
Project

Population pharmacodynamic/pharmacokinetic modelling in clinical pharmacology. (OC B15.10)

Population pharmacodynamic/pharmacokinetic modelling in clinical pharmacology of antiepileptic and antipsoriatic drugs....

FR - Farmakologie a lékárnická chemie

  • 1999 - 2003
    • •
  • 5 480 tis. Kč
    • •
  • 3 095 tis. Kč
    • •
  • MŠMT
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