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68 (0,131s) •

Project

Identification and characterization of genetic factors and pathogenetic mechanism of defects affecting de novo purine metabolism (NU23-01-00500)

Purine metabolism is integral to human life, and purines are the essential compounds providing energy to the body and forming our genetic code. Purines in the cell cytoplasm upon purine demand. Intermediates of

Biochemistry and molecular biology

  • 2023 - 2026
    • •
  • 9 637 tis. Kč
    • •
  • 9 637 tis. Kč
    • •
  • MZ
Project

Application of 7,8-Dihydropurines in the Synthesis of New Purine Derivatives with Potential Biological Activity (GA203/09/1552)

Reduction of purine derivatives to 7,8-dihydropurines and their easy re-oxidation back to the purines will be used in combination with suitable protective groups for the preparation of new purine derivatives that are not ea...

CC - Organická chemie

  • 2009 - 2012
    • •
  • 1 484 tis. Kč
    • •
  • 1 484 tis. Kč
    • •
  • GA ČR
Project

Synthesis of purine-purine and purine-pyrimidine dimers and purine trimers as analogues of Watson-Crick base pairs and Hoogsteen triplets (GA203/00/0036)

The aim of the project is the synthesis of several novel types of analogues of Watson-Crick base pairs and Hoogsteen triplets. Biaryl-type directly bound purine-purine and purine-pyrimidine dimers will be the first type of ...

CC - Organická chemie

  • 2000 - 2002
    • •
  • 1 659 tis. Kč
    • •
  • 1 456 tis. Kč
    • •
  • GA ČR
Project

Chemical and electrochemical analysis of purine derivatives and their copper complexes (LH13053)

devices of purine derivatives. The determination of purine derivatives has recently considerable effort has been devoted to the detection of normal purines using high and well suited for the detection of purines i...

CG - Elektrochemie

  • 2013 - 2015
    • •
  • 1 763 tis. Kč
    • •
  • 1 763 tis. Kč
    • •
  • MŠMT
Project

Synthesis of novel purine derivatives bearing functionalized C-substituents in the position 6 (GA203/03/0035)

The aim of this project is the development of the methodology of synthesis of purine derivatives bearing diverse highly functionalized C-substituents with enolates derived from ketones, carboxylates and amino acids, iii) generation of (p...

CC - Organická chemie

  • 2003 - 2005
    • •
  • 3 237 tis. Kč
    • •
  • 2 259 tis. Kč
    • •
  • GA ČR
Project

PURINE DE NOVO SYNTHESIS DEFECTS - METABOLIC STUDY (NR7796)

Purine bodies are synthesized de novo in ten step enzymatic pathway. Only two inherited metabolic defects have been identified. The reason is that current diagnostic of our work are to develop methods capable to follow human intracellular

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 1 419 tis. Kč
    • •
  • 1 412 tis. Kč
    • •
  • MZ
Project

New purine nucleoside analogues for therapeutic applications (OC D13.20)

Synthesis of purine nucleosides, heir acyclic analogues and analogues of nucleotides substituted by C=alkyl, aryl and cycloalkyl substituents as purinoceptor modulators.......

CC - Organická chemie

  • 2001 - 2003
    • •
  • 2 662 tis. Kč
    • •
  • 1 335 tis. Kč
    • •
  • MŠMT
Project

New purine nucleoside analogues for therapeutic applications (1P04OCD13.20)

Synthesis of purine nucleosides, heir acyclic analogues and analogues of nucleotides substituted by C=alkyl, aryl and cycloalkyl substituents as purinoceptor modulators.......

FR - Farmakologie a lékárnická chemie

  • 2004 - 2004
    • •
  • 891 tis. Kč
    • •
  • 400 tis. Kč
    • •
  • MŠMT
Project

European structure for coordination of research and diagnosis of inherited purine and pyrimidine disorders (OK 352)

Inborn errors of purine and pyrimidine metabolism represent quite new disorders.The number of the enzyme defects has increased rapidly and now totals more than and frequently misdianosed.Objectives: a) To collect informations about purin...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1998 - 2001
    • •
  • 1 450 tis. Kč
    • •
  • 1 400 tis. Kč
    • •
  • MŠMT
Project

New screening system of genetic defects of the de novo purines synthesis and its application in differential diagnosis of patients with psychomotor retardation of unknown etiology (LH11031)

1)Preparation of the commercionally unavailable, isotopicaly labeled and non-labeled intermediates of the de novo purine synthesis (DNPS) in the ammount and purity allowing the calibration of the choosen detection methods. 2)Implementation o...

EB - Genetika a molekulární biologie

  • 2011 - 2013
    • •
  • 2 954 tis. Kč
    • •
  • 2 954 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 68