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10 (0,066s) •

Project

Effect of mixture on the development of tree species composition, structure and biomass (LD14063)

The aim of the proposed project is to determine long-term effects of development of mixture stands growth and coupling processes. Long term effects will be evaluated on the basis of historical data from previous projects, reports and analyses regardi...

GK - Lesnictví

  • 2014 - 2017
    • •
  • 2 202 tis. Kč
    • •
  • 2 202 tis. Kč
    • •
  • MŠMT
Project

THE USING OF THE TRAINER (COMPUTER) EQUIPMENT FOR THE WEAPONS AND WEAPON SYSTEMS (MO60010896301)

KA - Vojenství

  • 1996 - 1998
    • •
  • 399 tis. Kč
    • •
  • 399 tis. Kč
    • •
  • MO
Project

Improvement of the diagnostics of disorders of growth hormone secretion with the follow- up of growth hormone binding protein and IGF-binding protein 3 (IZ2344)

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1994 - 1997
    • •
  • 589 tis. Kč
    • •
  • 706 tis. Kč
    • •
  • MZ
Project

Identification of novel therapeutic approaches to achondroplasia via analysis of FGFR3 interaction with adapter protein Frs2 (NV15-33232A)

Activating mutations in fibroblast growth factor receptor 3 (FGFR3) account for the most prevalent form of dwarfism in humans, the achondroplasia. Excessive activation of FGFR3 causes premature chondrocyte growth arrest, abnormal extracellular matrix...

EB - Genetika a molekulární biologie

  • 2015 - 2018
    • •
  • 9 730 tis. Kč
    • •
  • 9 730 tis. Kč
    • •
  • MZ
Project

ESTABLISHING GENETIC DIAGNOSIS IN CHILDREN WITH GROWTH DISORDERS USING NEXT GENERATION SEQUENCING METHODS - A PATHWAY TOWARDS INDIVIDUALIZED THERAPY (NV16-31211A)

Human growth is strongly genetically determined. Four clinically defined conditions with short stature of unknown origin include (1) familiar short stature, (2) idiopathic short stature, (3) intrauterine growth retardation followed by postnatal growt...

FG - Pediatrie

  • 2016 - 2019
    • •
  • 10 673 tis. Kč
    • •
  • 10 673 tis. Kč
    • •
  • MZ
Project

Studies of aetiopathogenesis and optimising management in children with intrauterine growth restriction and persistent postnatal growth failure (NV18-07-00283)

About 5% of all neonates are born small-for-gestational-age (SGA) due to intrauterine growth restriction (IUGR) - with birth weight and/or length below -2 SD. About 90% of them experience spontaneous catch-up growth within the first two years of life...

Endocrinology and metabolism (including diabetes, hormones)

  • 2018 - 2022
    • •
  • 11 406 tis. Kč
    • •
  • 11 406 tis. Kč
    • •
  • MZ
Project

Prenatal treatment of achondroplasia (NU23-10-00550)

Achondroplasia (ACH) is the most common genetic form of human dwarfism, caused by activating mutations in receptor tyrosine kinase FGFR3. ACH is severe dwarfism, with adult stature height of 110-140 cm, and profound malformations involving head and s...

Cell biology

  • 2023 - 2026
    • •
  • 15 116 tis. Kč
    • •
  • 15 116 tis. Kč
    • •
  • MZ
Project

Short stature in children clinical, genetic and in vitro functional study of hormonal and molecular regulation and therapeutic options (NW25-07-00164)

Genetic regulation of growth involves hormonal systems (e.g. growth hormone [GH], sexual hormones), growth plate factors, and fundamental intracellular and intranuclear processes. The etiology of short stature, defined as body height lower than -2 st...

Paediatrics

  • 2025 - 2028
    • •
  • 12 221 tis. Kč
    • •
  • 12 221 tis. Kč
    • •
  • MZ
Project

Affordable and accessible Redefining the future of achondroplasia treatment with repurposed FGFR inhibitors (NW25-10-00107)

Achondroplasia (ACH) is the most common genetic form of human skeletal dysplasia and is caused by activating mutations in the FGFR3 receptor tyrosine kinase. ACH is a severe dwarfism with an adult height of about 140 cm and skeletal malformations tha...

Medicinal chemistry

  • 2025 - 2028
    • •
  • 12 008 tis. Kč
    • •
  • 12 008 tis. Kč
    • •
  • MZ
Project

Analysis of genetic causes of overgrowth and assessment of related oncological, musculoskeletal and cardiovascular risks (NU21-07-00335)

Human growth is genetically determined and represents a fundamental characteristic of healthy child development. Tall stature (+2 SD above the mean for age and sex) is a less frequent reason for detailed clinical investigation if compared to short st...

Human genetics

  • 2021 - 2025
    • •
  • 13 320 tis. Kč
    • •
  • 13 320 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 10