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Relationship between structure of acetylcholinesterase reactivators and their reactivation potency (GP305/07/P162)
of anticholinergics (atropine mainly) and acetylcholinesterase (AChE) reactivators (pralidoxime reactivators are not able to reactivate AChE inhibited by all potential nerve agents, the development of new AChE reactiva...
FR - Farmakologie a lékárnická chemie
- 2007 - 2009 •
- 963 tis. Kč •
- 963 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2007 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Biodistribution and real-time monitoring of free or apoferritin-encapsulated charged cholinesterase reactivators (GA22-14568S)
Oxime cholinesterase reactivators are used for life endangering intoxications reactivators) or experimental uncharged reactivators have very limited penetration to encapsulate the oxime reactivators, help their blo...
Toxicology
- 2022 - 2024 •
- 11 763 tis. Kč •
- 11 208 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2022 - 31. 12. 2024
Uznané náklady
Podpora ze státního rozpočtu (95%)
Poskytovatel: Grantová agentura České republiky
Encapsulation of cholinesterase reactivators using apoferritin for enhanced bioavailability in central nervous system (GA19-13628S)
, acetylcholinesterase reactivators (oximes) are used as causal antidotes. Currently, clinically used or promising experimental reactivators (so-called quaternary reactivators) have major, biocompatible delivery systems are...
Other clinical medicine subjects
- 2019 - 2023 •
- 7 996 tis. Kč •
- 7 996 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2019 - 31. 12. 2023
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Encapsulation of bisquaternary oxime reactivators into solid lipid nanoparticles for enhanced reactivation of cholinesterases in CNS (GA25-15339S)
Quaternary oxime reactivators of cholinesterases are used for life endangering of reactivators in CNS are studied. This project is focused on the proof of concept of encapsulation of bisquaternary oxime reactivators into so...
Neurosciences (including psychophysiology)
- 2025 - 2027 •
- 13 027 tis. Kč •
- 13 027 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2025 - 31. 12. 2027
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The Evaluation of Penetration of Different Acetylcholinesterase Reactivators through Blood-Brain Barrier (NS9748)
A penetration of different acetylcholinesterase reactivators through the blood-brain barrier will be studied. Firstly, the AChE reactivators will be assessed, the promising reactivators for in vivo evaluation will be chosen...
FR - Farmakologie a lékárnická chemie
- 2008 - 2010 •
- 928 tis. Kč •
- 928 tis. Kč •
- MZ
Řešení projektu: 1. 7. 2008 - 31. 12. 2010
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Utilization of special analytical methods for determination of the reactivity of raw materials (UEPRKKK201406)
The project deals with the reactivity of raw and technologically modified materials. Reactivity of the raw materials will be evaluated by the pozzolanic activity, and by the heat evolution of the reaction of Portland cement and mate...
JH - Keramika, žáruvzdorné materiály a skla
- 2014 - 2014 •
- 205 tis. Kč •
- 170 tis. Kč •
- KKV
Řešení projektu: 1. 5. 2014 - 30. 10. 2014
Uznané náklady
Podpora ze státního rozpočtu (83%)
Poskytovatel: Karlovarský kraj
Characteristics of chemically reactive liquids produced by non-equilibrium plasma (GA19-25026S)
promising way how to transfer reactivity from the plasma into the liquid and to produce a chemically reactive liquids with unique properties. The objective of this project is to advance fundamental understanding of chemical process...
Physical chemistry
- 2019 - 2022 •
- 7 375 tis. Kč •
- 6 454 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2019 - 30. 6. 2022
Uznané náklady
Podpora ze státního rozpočtu (88%)
Poskytovatel: Grantová agentura České republiky
New possibilities of therapy of cyclosin intoxication Synthesis and testing of new acethylcholinesterase reactivators (ONVLAJEP20031)
The aim of this project is synthetizing, in vitro and in vivo testing of new acetylcholinesterase reactivators that will be effective enough for treatment of cyclosin intoxication. Potentially effective compounds will be chosen from original...
FP - Ostatní lékařské obory
- 2003 - 2005 •
- 1 429 tis. Kč •
- 864 tis. Kč •
- MO
Řešení projektu: 1. 1. 2003 - 1. 1. 2005
Uznané náklady
Podpora ze státního rozpočtu (60%)
Poskytovatel: Ministerstvo obrany
The concept of organophosphate-inhibited non-selective cholinesterase reactivators (LUAUS23275)
new structural types of cholinesterase reactivators bearing two nucleophilic of the reactivator in the organophosphate-inhibited enzyme to achieve efficient enzyme reactivation (AChE, BChE or both). We expect to develop at...
Other medical science
- 2023 - 2027 •
- 9 736 tis. Kč •
- 9 736 tis. Kč •
- MŠMT
Řešení projektu: 1. 3. 2023 - 31. 12. 2027
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
Influence of the nerve agent and reactivators of Acetyl Choline Esterase on the Guinea Pig (OVUOFVZ200905)
, cyklosarine and reactivators AChE pralidoxim, obidoxim, trimedoxim, HI-6, methoxim. Next task is assesprotective effectively of reactivators. Also detection of AChE activity in organs after intoxication with nerve compound and fol...
FP - Ostatní lékařské obory
- 2009 - 2011 •
- 2 384 tis. Kč •
- 894 tis. Kč •
- MO
Řešení projektu: 1. 7. 2009 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (38%)
Poskytovatel: Ministerstvo obrany
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