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1 072 (0,122s) •

Project

Influence of allosteric modulators on specificity of coupling with G-proteins and desensitization of muscarinic receptors (GA305/05/0452)

In spite of preferential coupling of muscarinic receptors to distinct classes modulators that bind at secondary domains on the receptor not only influence receptor affinity for orthosteric ligands but also partially activat...

ED - Fyziologie

  • 2005 - 2007
    • •
  • 4 992 tis. Kč
    • •
  • 4 992 tis. Kč
    • •
  • GA ČR
Project

The role of angiotensin II type 2 receptors in the pathophysiology of renovascular hypertension (GA305/07/0167)

of the RAS is angiotensin II (ANG II) acting via two main receptors, namely AT1 and AT2 receptors. Most "classical" biological effects of ANG II (vasoconstriction, increased renal sodium reabsorption) are mediated through activatio...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2007 - 2009
    • •
  • 3 296 tis. Kč
    • •
  • 3 296 tis. Kč
    • •
  • GA ČR
Project

Functional consequences of GABAb receptor and the deubiquitinating enzyme USP14 association (GA204/05/0920)

Neurotransmitter receptors are expressed, targeted, modulated and destroyed. Proteins that interact with the receptors are the regulators. Ubiquitination is oneof of many proteins. In search for function of intracellular portions of...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 4 149 tis. Kč
    • •
  • 4 149 tis. Kč
    • •
  • GA ČR
Project

Intermittent androgen blockade abd androgen receptor mutation (NR7798)

Mechanism why intermittent androgen blockade selects androgen receptor. Whether androgen receptor mutations are responsible for progression to hormonally escaped tumourwill be examined. Changes of androgen receptors during ...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 478 tis. Kč
    • •
  • 398 tis. Kč
    • •
  • MZ
Project

Receptor-specific radiopharmaceuticals for imaging and therapy of cancers (GA305/07/0535)

Receptor imaging with radiolabelled receptor-specific peptides has proven. A new application is the use of these peptides for receptor-mediated therapy and biodistribution of new radiolabelled receptor-specific pep...

FR - Farmakologie a lékárnická chemie

  • 2007 - 2009
    • •
  • 2 670 tis. Kč
    • •
  • 2 670 tis. Kč
    • •
  • GA ČR
Project

Allosteric modulation of nicotinic receptors (IAA100110501)

receptor function. We will concentrate on analysis of physostigmine allosteric action on embryonic and adult mouse muscle nicotinic receptors. Wildtype receptors will be compared with receptors with reduced effica...

BO - Biofyzika

  • 2005 - 2008
    • •
  • 1 792 tis. Kč
    • •
  • 1 792 tis. Kč
    • •
  • AV ČR
Project

The role of cyroskeleton in degradation of glucocorticoid receptor GR) and aromatic hydrocarbon receptor (AhR) (1P05ME767)

clarification of molecular mechanisms involved in the transcription activity and degradation of GR as a result of disintegradion of cytosceleton...

CE - Biochemie

  • 2005 - 2006
    • •
  • 650 tis. Kč
    • •
  • 168 tis. Kč
    • •
  • MŠMT
Project

Glutamate receptor modulators synthesis and activity (GA203/01/0084)

Glutamate receptors in neuronal membranes affect many life functions in organisms. One type of glutamate receptors is connected with ion selective cationic channels and their activity depends on several ligands (modulators) bound to...

CC - Organická chemie

  • 2001 - 2003
    • •
  • 3 951 tis. Kč
    • •
  • 1 512 tis. Kč
    • •
  • GA ČR
Project

Quantitative analysis of somatostatin receptors in pituitary adenomas. (NT11344)

The aim of the study is quantitative analysis of somatostatin receptors expression in pituitary tumours and correlation of receptors expression profile with clinical and laboratory data. The second goal is to introduce PCR analysis ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2010 - 2013
    • •
  • 2 704 tis. Kč
    • •
  • 2 704 tis. Kč
    • •
  • MZ
Project

Structural determinants of transduction of the metabotropic glutamate receptors (NL6114)

Functional tests in the heterologous systems of glutamate metabotropic receptors modified using classical mutagenesis techniques will reveal the portions of the receptors involved in signal transduction determination Understanding t...

ED - Fyziologie

  • 2000 - 2002
    • •
  • 2 031 tis. Kč
    • •
  • 1 886 tis. Kč
    • •
  • MZ
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