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3 129 (0,199s)

Project

Deciphering the relationship between homologous recombination and gene silencing (GA23-05284S)

is an inherent mechanism of the recombination-dependent replication pathway. We will show that silencing depends on replication fork barriers and occurs primarily during DNAThe simultaneous activity of tr...

Biochemistry and molecular biology

  • 2023 - 2025
  • 7 260 tis. Kč
  • 7 260 tis. Kč
  • GA ČR
Project

Srs2 protein and its multifunctional role in recombination/repair processes (ME 888)

characterisation of anti-recombinant activity of Srs2 protein, its role in replication and DNA synthesis, regulation of its activity......

EI - Biotechnologie a bionika

  • 2006 - 2008
  • 6 586 tis. Kč
  • 2 200 tis. Kč
  • MŠMT
Project

Role of RECQ5 DNA helicase in maintenance of genomic stability (GA204/09/0565)

DNA replication forks often pause upon encounter of DNA damage in the DNA recombination, which can give rise to chromosomal rearrangements and induced tumorigenesis replication forks and restore the replication pro...

EB - Genetika a molekulární biologie

  • 2009 - 2013
  • 8 570 tis. Kč
  • 8 570 tis. Kč
  • GA ČR
Project

Resolution of replication-recombination DNA intermediates and its role in genomic instability (GA301/09/1917)

that are required for cleavage of replication and recombination intermediates with the possibleDNA replication is fundamental process of living cells that need to overcome the obstacles causing replication to stal...

CE - Biochemie

  • 2009 - 2011
  • 4 013 tis. Kč
  • 4 013 tis. Kč
  • GA ČR
Project

Loss of specific DNA repeats in response to dysfunction of CAF1 in plants (GAP501/11/0289)

replication, repair and recombination, telomere maintenance) in genome stability control. depositing histones H3/H4 onto replicating DNA. Arabidopsis CAF1 mutants show abnormal morphology, changes in gene silencing and inc...

EB - Genetika a molekulární biologie

  • 2011 - 2015
  • 8 686 tis. Kč
  • 8 686 tis. Kč
  • GA ČR
Project

Structural characterisation of RAD51-G4 complex and its biological role (GA25-17326S)

G-quadruplexes (G4s) are non-canonical DNA secondary structures that regulate DNA replication or transcription. RAD51 is a recombinase that functions in homologous recombination, promotes the processing of stalled replication

Biochemistry and molecular biology

  • 2025 - 2027
  • 8 703 tis. Kč
  • 8 703 tis. Kč
  • GA ČR
Project

Application of replication methods in pricing and hedging of financial derivatives at non-perfect market (GP402/05/P085)

replication methods. The strategy is based on setting-up of a portfolio that should have the same character as the replicated asset. Hence, we need to create a new "synthetic" asset.We can distinguish various kinds of replicati...

AH - Ekonomie

  • 2005 - 2007
  • 540 tis. Kč
  • 520 tis. Kč
  • GA ČR
Project

Mechanisms and dynamics of macromolecular complexes (EF15_003/0000441)

Project will clarify mechanism and operating of large macromolecular complexes such as complexes of photosynthetic pigments, a role in the replication of RNA viruses and folding and regulation of cellular processes, recombination me...

EE - Mikrobiologie, virologie

  • 2016 - 2023
  • 207 410 tis. Kč
  • 194 945 tis. Kč
  • MŠMT
Project

Study of electron-ion and ion-ion recombination in low temperature plasma (GA202/99/D061)

Recombination is one of processes leading to losses of ionization in the plasma. Recombination coefficients depend strongly on type of recombination, type of particles involved in recombination, temperatur...

BL - Fyzika plasmatu a výboje v plynech

  • 1999 - 2002
  • 704 tis. Kč
  • 605 tis. Kč
  • GA ČR
Project

HMGB1 role in modulation of tumor suppressors and telomere integrity (GA204/05/2031)

including DNA replication, recombination, transcription, cell signaling, tumor growth and metastasis) could differentially modulate p53-dependent transactivation of genes involved is to decipher arole of Rb and HMGBl in p5...

CE - Biochemie

  • 2005 - 2007
  • 3 528 tis. Kč
  • 3 528 tis. Kč
  • GA ČR
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