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150 (0,145s) •

Project

Immunohistochemical and ultrastructural evaluation of airway wall remodeling in experimentally provoked bronchial asthma (NT11459)

in the expression of several factors participating in the remodeling of bronchial walls. Wewill common mechanisms of the airway wall remodeling. We suppose the differences in the level of the airway remodeling and in the e...

EA - Morfologické obory a cytologie

  • 2010 - 2013
    • •
  • 3 044 tis. Kč
    • •
  • 3 044 tis. Kč
    • •
  • MZ
Project

Genetic determinants of interstitial fibrosis and coronary microvascular remodelation (LH11049)

We will use histomorphometric analyses to determine the presence and extent of coronary microvascular remodeling and myocardial fibrosis in the BXH/HXB recombinant inbred strains derived from the spontaneously hypertensive rats (SHR) and Bro...

EB - Genetika a molekulární biologie

  • 2011 - 2014
    • •
  • 3 564 tis. Kč
    • •
  • 3 564 tis. Kč
    • •
  • MŠMT
Project

The role of immune system in remodelation of pulmonary arteries during pulmonary hypertension (LTAUSA18107)

of pulmonary artery wall with pulmonary hypertension. Aim 3. To determine remodeling in pulmonary artery remodeling and to study remodeling of cells from pulmonary wall in vivo......

Physiology (including cytology)

  • 2019 - 2022
    • •
  • 7 928 tis. Kč
    • •
  • 7 928 tis. Kč
    • •
  • MŠMT
Project

Role of chromatin remodeling proteins in hematopoietic stem cells and leukemogenesis (LH15170)

The proposed results include: a) new gene-inactivated and b) transgenic models to study chromatin-remodeling gene Smarca5 (Snfa2h) in mouse. The results are primarily academic such as the new knowledge of a) what mechanisms utilize Smarca5 d...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 1 985 tis. Kč
    • •
  • 1 985 tis. Kč
    • •
  • MŠMT
Project

Alternative Right Ventricular Pacing Site A randomized study comparing the effect of apical versus midseptal pacing site on LV remodeling (NR8553)

The purpose of a prospective randomized study is to compare long-term effect of conventional and alternative right ventricular pacing site on left ventricular remodelling in patients with preserved left ventricular function. The assessment o...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2005 - 2007
    • •
  • 2 716 tis. Kč
    • •
  • 2 660 tis. Kč
    • •
  • MZ
Project

Impact of increased cardiomyocyte proliferation on cardiac electrical remodeling and vulnerability to arrhythmias in pressure overloaded neonatal heart (NU21J-02-00039)

Electrical remodeling of pressure overloaded myocardium represents an important risk factor for life-threatening arrhythmias development. Aim of this project is elucidate impact of increased cardiomyocyte proliferative activity on adverse e...

Cardiac and Cardiovascular systems

  • 2021 - 2025
    • •
  • 6 621 tis. Kč
    • •
  • 6 621 tis. Kč
    • •
  • MZ
Project

Ultra-high-frequency ECG for prediction of adverse left ventricular remodeling in permanent right ventricular pacing (NU21-02-00584)

for a method of pacing that can avoid adverse left ventricular (LV) remodeling and heart are at the highest risk of adverse LV remodeling. His bundle and left bundle branch pacings offer remodeling. Dyssynchronous ventricu...

General and internal medicine

  • 2021 - 2025
    • •
  • 12 075 tis. Kč
    • •
  • 10 993 tis. Kč
    • •
  • MZ
Project

Contribution of repeated measurement of B-type natriuretic peptide to standard management in patients with recently diagnosed and advanced heart failure (NR9400)

The value of repeated measurements of BNP will be studied in the patients with recent-onset and advanced chronic heart failure with special emphasis on prognosis and LV remodeling.......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2007 - 2009
    • •
  • 2 066 tis. Kč
    • •
  • 2 043 tis. Kč
    • •
  • MZ
Project

Understanding the factors critical for successful paternal genome remodelling Dissecting the role of oocyte components (GA20-04465S)

At fertilisation, two highly specialized cells, the egg and sperm, meet. To support development, the sperm head must be extensively remodelled by the egg. Factors critical for this remodelling and pronucleus formation reside in the ...

Reproductive biology (medical aspects to be 3)

  • 2020 - 2022
    • •
  • 6 645 tis. Kč
    • •
  • 6 645 tis. Kč
    • •
  • GA ČR
Project

The effect of histone deacetylase inhibitors on TEL/AML1 - positive leukaemic cells (NR8316)

Using histone deacetylase inhibitors, we will study chromatin remodelling leading to apoptosis and differentiation of TEL/AML1-positive leukaemic cells. We will analyse in vitro effect of this therapy on the changes of cell cycle and the gen...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 3 877 tis. Kč
    • •
  • 3 834 tis. Kč
    • •
  • MZ
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