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1 265 (0,108s) •

Project

Replication and chromatin organization in human cells (GA304/05/0374)

cells is arranged into replication domains of similar size. We want to test whether this arrangement is common also for diploid human fibroblasts, replication domains have structural basis and the replication<...

EA - Morfologické obory a cytologie

  • 2005 - 2007
    • •
  • 4 362 tis. Kč
    • •
  • 4 362 tis. Kč
    • •
  • GA ČR
Project

Replication of mammalian genome ? 4D view (KJB500390701)

and formation of replication domains (RDs). These EM entities were earlier described in HeLa cells. In this respect, we want to test whether replication via RDs presents commonEucaryotic DNA replication ensures ac...

EA - Morfologické obory a cytologie

  • 2007 - 2009
    • •
  • 1 710 tis. Kč
    • •
  • 1 710 tis. Kč
    • •
  • AV ČR
Project

Compartmentalization of the Cell Nucleus Ultrastructural Immunocytochemistry Identifies Structure-Function Domains Induced by DNA Replication (IA73952)

9H - 9

  • 1992 - 1994
    • •
  • 0 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • AV ČR
Project

Spatial organisation of key nuclear domains and their protein components (LTC18048)

a) To determine the distribution of replication and transcription in the nucleolar subdomains b) To analyse distribution of histone variants in the nucleolar DNA fraction c) To create an interaction network of histone chaperones and select...

Plant sciences, botany

  • 2018 - 2021
    • •
  • 3 430 tis. Kč
    • •
  • 3 430 tis. Kč
    • •
  • MŠMT
Project

Molecular nature of DNA replication-coupled chromatin modulation (GA304/06/1691)

The aim of the project is to reveal molecular nature of recently described (Fidlerova et al, J. Cell. Biochem. 94: 899-916, 2005) replication-coupled, cell cycle dependent modulation of early replicating chromatin domains m...

EA - Morfologické obory a cytologie

  • 2006 - 2008
    • •
  • 4 731 tis. Kč
    • •
  • 4 731 tis. Kč
    • •
  • GA ČR
Project

Dynamic structure and function in the cell nucleus (GA304/00/1481)

aims: 1) To show that independent units of gene activity (= domains), into which theinterphase chromatin appears to be organized, correspond in fact to replication domains knowledge about the replication process i...

EA - Morfologické obory a cytologie

  • 2000 - 2002
    • •
  • 7 443 tis. Kč
    • •
  • 3 359 tis. Kč
    • •
  • GA ČR
Project

Functional organization of the cell nucleus (GA302/99/0587)

place in the cell nucleus, particularly about the integration of DNA replication (= domains) and we wanto characterize in Drosophila polytene chromosomes the higher order arrangement of chromatin in the boundary elements which insu...

EA - Morfologické obory a cytologie

  • 1999 - 2001
    • •
  • 7 773 tis. Kč
    • •
  • 6 632 tis. Kč
    • •
  • GA ČR
Project

Elucidating the molecular mechanisms of DNA crosslink repair by replication-coupled DNA repair (GA24-12306S)

and its zinc finger domain (NZF) to repair the Ap-ICL allowing the replication). Generally, ICLs block replication and can lead to genomic instability, cell death, or cancer. Upon collision with the Ap-ICL, the helicase of...

Biochemistry and molecular biology

  • 2024 - 2026
    • •
  • 8 858 tis. Kč
    • •
  • 8 489 tis. Kč
    • •
  • GA ČR
Project

Design, characterization and mechanism of action of novel inhibitors of HIV assembly (GA13-19561S)

arsenal against HIV comprises compounds blocking all major steps of HIV replication antiretroviral strategies and block the replication of resistant virus strains. Based on our the interaction of the C-terminal domain of H...

EB - Genetika a molekulární biologie

  • 2013 - 2016
    • •
  • 11 267 tis. Kč
    • •
  • 11 267 tis. Kč
    • •
  • GA ČR
Project

Cytogenetic study of nuclear chromatin organization in plants (GA522/03/0354)

, heterochromatin domains, location of prominent chromosomal structures as telomeres andcentomeres) has substantial significance on gene expression and DNA replication during of the correlation of chromatin activity with early r...

ED - Fyziologie

  • 2003 - 2005
    • •
  • 6 924 tis. Kč
    • •
  • 3 226 tis. Kč
    • •
  • GA ČR
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