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7 738 (0,244s) •

Project

Induction of apoptosis in cancer cells by mitochondria-specific compounds; the role of respiratory complex II (GAP301/12/1851)

Redox-silent vitamin E (VE) analogues, such as alpha-tocopheryl succinate (aTOS), eliminate cancer cells by mitochondrially-mediated apoptosis. Respiratory complex II (CII), which converts succinate to fumarate in the Krebs...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 5 217 tis. Kč
    • •
  • 5 217 tis. Kč
    • •
  • GA ČR
Project

Mitochondrial respiratory complex II deficiency in cancer development (GA17-20904S)

Respiratory complex II (CII) deficiency leads to cancer, with reactive oxygen species (ROS) and increased succinate suggested as causal agents. For unclear reasons, the clinical outcomes differ substantially depending on wh...

CE - Biochemie

  • 2017 - 2019
    • •
  • 5 724 tis. Kč
    • •
  • 5 724 tis. Kč
    • •
  • GA ČR
Project

Composition and Function of CII-low, an Alternative Assembly Form of Respiratory Complex II (GA19-20553S)

Recently we identified an alternative form of respiratory complex II (CII) that we designated CII-low. CII-low consists of the SDHA subunit associated with an incompletely defined set of its assembly factors, and becomes th...

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 8 113 tis. Kč
    • •
  • 8 113 tis. Kč
    • •
  • GA ČR
Project

Consequences of respiratory complex II deficiency for endothelial cell physiology (GN24-10588I)

A policeman that directs traffic between the tricarboxylic acid cycle and the electron transport chain. Complex II/Succinate dehydrogenase (CII/SDH) manages two major metabolic pathways, but its role in endothelial physiology is not...

Cell biology

  • 2024 - 2026
    • •
  • 6 546 tis. Kč
    • •
  • 6 546 tis. Kč
    • •
  • GA ČR
Project

Mitochondrial respiratory complex II aberrations as complication in renal cancer therapy based on mitochondrial targeting (NU23-03-00226)

with the agent. Since MitoTam has mitochondrial respiratory complex I (CI) as its molecular target and since renal cancer has anomalies in the expression of complex II (CII......

Biochemistry and molecular biology

  • 2023 - 2026
    • •
  • 12 546 tis. Kč
    • •
  • 12 546 tis. Kč
    • •
  • MZ
Project

Alternative splicing of SUCLG2 and mitochondrial complex II regulation in endocrine cancer (NW25-03-00282)

We have recently described mutations in SUCLG2, a subunit of SUCL, in endocrine tumours, and found that this affected considerably assembly and function of mitochondrial respiratory complex II (CII). When studying the role ...

Biochemistry and molecular biology

  • 2025 - 2028
    • •
  • 15 457 tis. Kč
    • •
  • 15 457 tis. Kč
    • •
  • MZ
Project

Maturation of mitochondrial energy metabolism in perinatal period (NE6555)

of the project is to study proces of maturation of PDH and respiratory chain complexes and respiratory chain complexes in muscle mitochondria due to low amount of mitochondrial......

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 5 560 tis. Kč
    • •
  • 3 639 tis. Kč
    • •
  • MZ
Project

Modelling of the Human Respiratory System (GP102/09/P618)

Transdisciplinary Research in the Field of Biomedical Engineering II. The main activity of the project is modelling of the respiratory system.In spite of substantial development. The necessary trend is minimization of the risk of t...

JA - Elektronika a optoelektronika, elektrotechnika

  • 2009 - 2009
    • •
  • 172 tis. Kč
    • •
  • 172 tis. Kč
    • •
  • GA ČR
Project

Etiopathogenetic factors in complex treatment of recurrent respiratory papillomatosis (IZ3167)

9F - 9

  • 1995 - 1996
    • •
  • 150 tis. Kč
    • •
  • 150 tis. Kč
    • •
  • MZ
Project

Pathophysiological function of mitochondrial glycerophopsphate dehydrogenase - production of reactive oxygen species (GA303/06/1261)

, respiratory chain complexes I, III, and ketoglutarate dehydrogenase and dependency of ROS production by particular enzyme complex on mitochondrial membrane potential, DpH, which can be responsible for low protection of mG...

CE - Biochemie

  • 2006 - 2008
    • •
  • 4 089 tis. Kč
    • •
  • 4 089 tis. Kč
    • •
  • GA ČR
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