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The analysis of molecular organization of the retrovirus particle and interactions leading to its assembly (ME 904)
The aim is to employ a multi-methodical approach to study various aspects of formation of retroviral particles. This will be made possible by the employment. Hunter resides in a multi-methodical approach to the study of the mechanism of ...
EE - Mikrobiologie, virologie
- 2007 - 2011 •
- 2 391 tis. Kč •
- 2 391 tis. Kč •
- MŠMT
Řešení projektu: 1. 5. 2007 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
Structural study of protein domains of monkey retrovirus (IAA4055304)
domains involved in the assembly of retroviral capsid.Temporal and spatial separation of assembly of immature capsid particles from their release makes Mason-Pfizer monkey virus (M-PMV), inducing an AIDS like syndrom in no...
CE - Biochemie
- 2003 - 2007 •
- 11 354 tis. Kč •
- 4 282 tis. Kč •
- AV ČR
Řešení projektu: 1. 1. 2003 - 1. 12. 2007
Uznané náklady
Podpora ze státního rozpočtu (38%)
Poskytovatel: Akademie věd České republiky
Modulation of capsid protein hexameric lattice stability a promising target for HIV-1 inhibition (GA20-19906S)
The immature and mature lattices of retroviral particles are both formed of capsid protein (CA) hexamers, however their inter-hexamer and intra-hexamer contacts differ. Any modulation of both immature and mature CA lattices stabilit...
Virology
- 2020 - 2022 •
- 6 940 tis. Kč •
- 6 604 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2020 - 31. 12. 2022
Uznané náklady
Podpora ze státního rozpočtu (95%)
Poskytovatel: Grantová agentura České republiky
Structural and functional study of matrix protein and proteinaseof monkey immunosuppressive retrovirus (GA203/97/0416)
of retroviral capsid assembly. Matrix gene will be cloned and expressed in E. coli model system for its intracytoplasmic assembly of capsid shell. A point mutation-type (e.g. HIV-1) which assembles its capsids at ...
CE - Biochemie
- 1997 - 1999 •
- 2 843 tis. Kč •
- 1 809 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 1997 - 1. 1. 1999
Uznané náklady
Podpora ze státního rozpočtu (64%)
Poskytovatel: Grantová agentura České republiky
Structure and assembly of retroviral proteins - specific domains responsible for these processes (GA203/00/1005)
The mechanism of retroviral capsid formation is still poorly understood despite the extensive scientific effort aimed at these steps in HIV. The inhibition of any step in assembly and intracellular transport of viral proteins would ...
CE - Biochemie
- 2000 - 2002 •
- 2 415 tis. Kč •
- 2 115 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2000 - 1. 1. 2002
Uznané náklady
Podpora ze státního rozpočtu (88%)
Poskytovatel: Grantová agentura České republiky
Study of relationships between structure and function of phenotypically relevant mutants of Mason-Pfizer monkey virus matrix protein (GA203/03/0490)
of phenotypically relevant mutants of retroviral matrix protein (MA), which is common to all andplays a key role in the process of capsid assembly. It is responsible for assembly or for transport of capsids to the plasma m...
CE - Biochemie
- 2003 - 2005 •
- 5 104 tis. Kč •
- 3 346 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2003 - 1. 1. 2005
Uznané náklady
Podpora ze státního rozpočtu (66%)
Poskytovatel: Grantová agentura České republiky
The effect of mutations and morphogenetic differences in matrix proteins on assembly and transport of retroviral capsids (GA203/98/P151)
Matrix protein (MA) of Mason-Pfizer monkey virus (M-PMV), which is the prototype of the type D retroviruses, plays a critical role in retroviral replication cycle. A mutant of MA, which changes morphogenetic type D to that of C will be clone...
CE - Biochemie
- 1998 - 2000 •
- 822 tis. Kč •
- 703 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 1998 - 1. 1. 2000
Uznané náklady
Podpora ze státního rozpočtu (86%)
Poskytovatel: Grantová agentura České republiky
In vitro preparation of recombinant capsids for nucleic acids incorporation and internalization in the cell tissue (GP203/03/P094)
compounds into their particles. Detailed research of retroviral life cycle, process of capsid assembly and mechanism of infections can significantly contribute to better will further study binding of nucleic acids to proteins formi...
EE - Mikrobiologie, virologie
- 2003 - 2005 •
- 750 tis. Kč •
- 750 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2003 - 1. 1. 2005
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Interactions betwen viral and host cell proteins from purification of macromolecular complexes to high-resolution structures (GESCO/06/E001)
of the retroviral life cycle. Such complexes remain poorly characterized despite being essential of proviral DNA into the host genome, in targeting of retroviral polyproteins in the intracellular sites of assembly of immature c...
CE - Biochemie
- 2006 - 2009 •
- 4 500 tis. Kč •
- 4 500 tis. Kč •
- GA ČR
Řešení projektu: 1. 6. 2006 - 31. 5. 2009
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Study of interactions of biological macromolecules and nanolayers with a view to research of polymer microfluidic biosensors and therapeutic nanoparticles (KAN208240651)
Aim of the proposed project is a research of highly integrated microfluidic equipment (biosensors) based on the detection of biologically specific components from the sample using immobilized protein nanolayers and a research of organization of macro...
CI - Průmyslová chemie a chemické inženýrství
- 2006 - 2010 •
- 19 997 tis. Kč •
- 17 458 tis. Kč •
- AV ČR
Řešení projektu: 1. 7. 2006 - 31. 12. 2010
Uznané náklady
Podpora ze státního rozpočtu (87%)
Poskytovatel: Akademie věd České republiky
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