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458 (0,111s) •

Project

The analysis of molecular organization of the retrovirus particle and interactions leading to its assembly (ME 904)

interesting retroviral mutants that are studied in the laboratory of PI will be comparedThe aim is to employ a multi-methodical approach to study various aspects of formation of retroviral particles. This will be made poss...

EE - Mikrobiologie, virologie

  • 2007 - 2011
    • •
  • 2 391 tis. Kč
    • •
  • 2 391 tis. Kč
    • •
  • MŠMT
Project

Interactions betwen viral and host cell proteins from purification of macromolecular complexes to high-resolution structures (GESCO/06/E001)

of the retroviral life cycle. Such complexes remain poorly characterized despite being essential mutants by identification new targets for drug design. Here we propose toanalyze of proviral DNA into the host genome, in targeting of...

CE - Biochemie

  • 2006 - 2009
    • •
  • 4 500 tis. Kč
    • •
  • 4 500 tis. Kč
    • •
  • GA ČR
Project

Dimerisation of retroviral proteinases characterisation, structure-activity and inhibition study (GA303/98/1559)

All retroviral proteins are expressed as polyprotein precursors. Specific of mature, infectious particles. Retroviral PRs are thus an attractive target for antiviral chemotherapy. All retroviral PRs are active as dimers. Th...

CE - Biochemie

  • 1998 - 2000
    • •
  • 2 878 tis. Kč
    • •
  • 2 643 tis. Kč
    • •
  • GA ČR
Project

The effect of mutations and morphogenetic differences in matrix proteins on assembly and transport of retroviral capsids (GA203/98/P151)

Matrix protein (MA) of Mason-Pfizer monkey virus (M-PMV), which is the prototype of the type D retroviruses, plays a critical role in retroviral replication cycle. A mutant of MA, which changes morphogenetic type D to that of C will...

CE - Biochemie

  • 1998 - 2000
    • •
  • 822 tis. Kč
    • •
  • 703 tis. Kč
    • •
  • GA ČR
Project

Study of structure, function and inhibition of retroviral integrase and proteinase (IAA4055904)

of integration, we will express the integrase (IN) and the mutants of IN of virus M-PMV, will be tested. For activation of retroviral proteolysis, we will express the proteinase (PR......

CE - Biochemie

  • 1999 - 2001
    • •
  • 8 099 tis. Kč
    • •
  • 1 959 tis. Kč
    • •
  • AV ČR
Project

Structure of retroviral particle and intracellular transport of its components. (LH12011)

Vectors expressing fluorescently tagged envelope and structural protein mutants of M-PMV altering assembly, transport or capsid release will be prepared. ?Live transport in cells co-transfected with mutants of viral glycoproteins an...

EE - Mikrobiologie, virologie

  • 2012 - 2015
    • •
  • 1 990 tis. Kč
    • •
  • 1 990 tis. Kč
    • •
  • MŠMT
Project

Interactions of syncytins with specific cell receptors (GA17-14356S)

fusion instead of cell-to-cell fusion. We plan to prepare infectious retroviral with wild-type or mutant receptors. We will delete extracellular loops in order......

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 7 524 tis. Kč
    • •
  • 6 717 tis. Kč
    • •
  • GA ČR
Project

Structure, function, substrate specificity and inhibition of retroviral proteinases protein engineering study of retroviral processing (IA455102)

CE - Biochemie

  • 1993 - 1994
    • •
  • 0 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • AV ČR
Project

The role of the ubiquitin and ubiquitin-like proteins in life cycle of the Mason-Pfizer monkey virus (GP301/06/P278)

for the forming of infective retroviral particles have been proved. Tha major aim of retroviral particle of Mason-Pfizer Monkey Virus (M-PMV). The goal is to find and transport of retroviral RNA, course of assembly and inf...

EE - Mikrobiologie, virologie

  • 2006 - 2008
    • •
  • 1 167 tis. Kč
    • •
  • 1 167 tis. Kč
    • •
  • GA ČR
Project

Study of relationships between structure and function of phenotypically relevant mutants of Mason-Pfizer monkey virus matrix protein (GA203/03/0490)

The project is focused on a structural study of functional domains of phenotypically relevant mutants of retroviral matrix protein (MA), which is common to all replication competent viruses. MA protein forms the outer protein shell ...

CE - Biochemie

  • 2003 - 2005
    • •
  • 5 104 tis. Kč
    • •
  • 3 346 tis. Kč
    • •
  • GA ČR
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