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Projects

39 projects (0,204s) •

Project

Regulation of active endogenous retroviruses in the mammalian genome (LK11215)

Characterization of epigenetic regulations in a unique model of a highly polymorphic mammalian endogenous retrovirus. Genetic and virological characterization of this endogenous retrovirus. Searching for a similar polymorphism in ot...

EE - Mikrobiologie, virologie

  • 2012 - 2016
    • •
  • 14 077 tis. Kč
    • •
  • 14 077 tis. Kč
    • •
  • MŠMT
Project

The Study of the Conformation of Structural Proteins of Monkey Retrovirus M-PMV Proteolytic Cleavage and Its Inhibition. (GA203/94/1323)

CE - Biochemie

  • 1994 - 1996
    • •
  • 2 188 tis. Kč
    • •
  • 2 441 tis. Kč
    • •
  • GA ČR
Project

IL-2 and IL-6 Therapy of Residual Disease in Preclinical Models of Myeloid Leukaemia, Plasmacytomas and Retrovirus-Induced Sarcomas (IAA752103)

9H - 9

  • 1993 - 1995
    • •
  • 232 tis. Kč
    • •
  • 464 tis. Kč
    • •
  • AV ČR
Project

Study of integrase and pre-integration complex of monkey retrovirus (GP203/05/P557)

replication. Mason-Pfizer Monkey Virus (M-PMV), a representative of ß-retrovirus family, has been intensively studied as a "model" retrovirus in our laboratory. Neither......

CE - Biochemie

  • 2005 - 2007
    • •
  • 1 140 tis. Kč
    • •
  • 1 140 tis. Kč
    • •
  • GA ČR
Project

Intracellular trafficking of retroviral proteins and recruitment of envelope glycoproteins (GA17-24281S)

of principles of late events of retrovirus life cycle by studying interactions and transport of structural proteins precursors (Gag) of morphogenetically distinct retroviruses. We recycling pathways in Gag trafficking and in recrui...

EE - Mikrobiologie, virologie

  • 2017 - 2019
    • •
  • 5 634 tis. Kč
    • •
  • 5 268 tis. Kč
    • •
  • GA ČR
Project

DNA-repair genes transfer to hematopoietic cells for protection against toxic and mutagenic effects of alkylating antitumor agents. (IZ3557)

FD - Onkologie a hematologie

  • 1996 - 1998
    • •
  • 3 160 tis. Kč
    • •
  • 3 160 tis. Kč
    • •
  • MZ
Project

Study of structure, function and inhibition of retroviral integrase and proteinase (IAA4055904)

Retroviruses encode the enzymes that catalyze essential steps in the replication cycle which become an attractive targets for antiviral chemotherapy. Despite concentrated research effort aimed at the understanding the molecular biology of

CE - Biochemie

  • 1999 - 2001
    • •
  • 8 099 tis. Kč
    • •
  • 1 959 tis. Kč
    • •
  • AV ČR
Project

Study of protein interaction involved in retrovirus particle assembly using two-hybrid systems (GP203/02/P020)

Late in the retrovirus life cycle the viral structural polyprotein, precursors form immature virus particles that are then released from the plasma membrane of the infected cell. Assembly of these immature structures is directed by the Gag p...

CE - Biochemie

  • 2002 - 2004
    • •
  • 835 tis. Kč
    • •
  • 698 tis. Kč
    • •
  • GA ČR
Project

Chicken polymorphisms in retroviral receptors and their potential for cross-species transmission (GA13-30983S)

The main goal of our project will be to characterize the polymorphisms in chicken XPR1, ASCT1, and Tvj, receptors for murine xenotropic viruses, endogenous retrovirus RD114, and subgroup J avian leukosis virus, respectively. Using viral th...

EB - Genetika a molekulární biologie

  • 2013 - 2017
    • •
  • 5 930 tis. Kč
    • •
  • 5 930 tis. Kč
    • •
  • GA ČR
Project

Characterization of the cellular receptor Tvc and its role in the pathogenesis of avian leukosis viruses subgroup C-induced diseases (GA523/07/1282)

Tvcs for different retroviruses of subgroup C. To get insight...

GG - Chov hospodářských zvířat

  • 2007 - 2009
    • •
  • 4 690 tis. Kč
    • •
  • 4 690 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 39