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1 899 (0,108s) •

Project

Systems genetic approach for identifying genes predisposing to salt-sensitive hypertension in the rat (LUAUS25164)

) is a key model for the study of salt-sensitive hypertension. In search of the molecular mechanisms underlying salt-sensitive hypertension, we studied a set of recombinant inbred (RI) HXB/BXH strains (N=30) derive...

Cardiac and Cardiovascular systems

  • 2025 - 2028
    • •
  • 5 172 tis. Kč
    • •
  • 5 172 tis. Kč
    • •
  • MŠMT
Project

Contribution of the RAAS to the pathophysiology of salt-sensitive hypertension a study in renin transgenic rats with inducible hypertension (GP305/08/P053)

Recent studies have implicated an important role of the renin-angiotensin-aldosterone system (RAAS) in the development of salt-sensitive hypertension. This study should address the issue whether the salt sensitivity

ED - Fyziologie

  • 2008 - 2010
    • •
  • 1 485 tis. Kč
    • •
  • 1 485 tis. Kč
    • •
  • GA ČR
Project

Salt sensitivity of blood pressure in the rat membrane-related markers and genetic factors (GA306/95/0614)

ED - Fyziologie

  • 1995 - 1997
    • •
  • 710 tis. Kč
    • •
  • 710 tis. Kč
    • •
  • GA ČR
Project

on pathophysiology of salt-sensitive hypertension and renal injury (LH11116)

The main objective of our projects is to identify the functional interactions between RAAS and CYP450 effect that are involved in the regulation of blood pressure and its impact on pathophysiology of salt-sensitive and angiotensin I...

ED - Fyziologie

  • 2011 - 2013
    • •
  • 1 120 tis. Kč
    • •
  • 1 120 tis. Kč
    • •
  • MŠMT
Project

Positional cloning of a gene on chromosome 18 that is repsonsible for hypertension and salt sensitivity in the spontaneously hypertensive rat (GA301/04/0390)

on blood pressure and salt sensitivity. To test this hypothesis, we developed a new congenicstrain, to genetically isolate QTL responsible for hypertension and salt sensitivity to salt-induced increases i...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 3 828 tis. Kč
    • •
  • 3 828 tis. Kč
    • •
  • GA ČR
Project

European Project on Genes in Hypertension (EPOGH) (OK 375)

variability, examination of ion handling (salt sensitivity by means of lithium clearance...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 1999 - 2002
    • •
  • 1 197 tis. Kč
    • •
  • 1 157 tis. Kč
    • •
  • MŠMT
Project

Abnormalities of red cell potassium and sodium transport as markers for salt sensitivity of blood pressure. (IZ3509)

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 1996 - 1998
    • •
  • 804 tis. Kč
    • •
  • 616 tis. Kč
    • •
  • MZ
Project

Central and peripheral modulation of vascular tone and sodium excretion the role of brain and kidney in pathophysiology of hypertension (NV15-25396A)

of vascular tone and is also responsible for abnormal renal function in salt-sensitive of several forms of experimental hypertension resembling human salt-sensitive or salt regulator of renal function in ...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2015 - 2019
    • •
  • 9 534 tis. Kč
    • •
  • 9 534 tis. Kč
    • •
  • MZ
Project

Neurohumoral control of calcium influx nifedipine-sensitive component of blood pressure in experimental hypertension (IAA500110902)

Both spontaneous and salt hypertension are characterized by sympathetic hyperactivity and relative NO deficiency resulting in the imbalance of pressor and depressor rats is associated with enhanced nifedipine-sensitive blood pressur...

ED - Fyziologie

  • 2009 - 2011
    • •
  • 4 157 tis. Kč
    • •
  • 4 157 tis. Kč
    • •
  • AV ČR
Project

Mechanisms of Salt-Induced Hypertension in Primary Aldosteronism (LUAUS23095)

of salt-sensitivity in PA are the subject of intense interest. The current proposal is the hemodynamic abnormality through which aldosterone enables increases in salt intake are addressing is whether aldosterone enables in...

Cardiac and Cardiovascular systems

  • 2023 - 2027
    • •
  • 3 362 tis. Kč
    • •
  • 3 362 tis. Kč
    • •
  • MŠMT
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