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81 (0,091s) •

Project

Functional and structural consequences of pilocarpineinduced status epilepticus in immature and adult rats (IAA7011603)

Consequences of epileptic seizures may depend not only on seizure type and severity, but also on the age when seizures appear. These factors will be studied in a model of pilocarpineinduced seizures in rats. High d...

ED - Fyziologie

  • 1996 - 1998
    • •
  • 3 166 tis. Kč
    • •
  • 1 585 tis. Kč
    • •
  • AV ČR
Project

Cellular, network and metabolic mechanisms responsible for long-term fluctuations in seizure probability (GA21-17564S)

to a contrasting state like a seizure, depressive episode, or panic attack, is not well understood. A seizure is one of the most extreme states, and the reasons behind its on our recent breakthroughs that the seizure repre...

Neurosciences (including psychophysiology)

  • 2021 - 2023
    • •
  • 10 954 tis. Kč
    • •
  • 10 954 tis. Kč
    • •
  • GA ČR
Project

The role of miRNA in development of glutamatergic and GABAergic signaling after early-life seizures (GA19-11931S)

Recurrent or prolonged seizures in the developing brain are associated in the altered excitability and thus higher susceptibility to seizures. Early developmental have been previously associated with both seizures and neuro...

Developmental biology

  • 2019 - 2022
    • •
  • 10 218 tis. Kč
    • •
  • 9 723 tis. Kč
    • •
  • GA ČR
Project

Large-scale dynamics and critical transitions in neuronal networks and their role in limbic seizure genesis. (GA14-02634S)

Transition to epileptic seizure represents sudden and abrupt shift between demonstrated that seizures are preceded by detectable changes in neuronal behaviour which to transition to seizure. These processes correspond to ph...

FH - Neurologie, neurochirurgie, neurovědy

  • 2014 - 2018
    • •
  • 7 697 tis. Kč
    • •
  • 7 697 tis. Kč
    • •
  • GA ČR
Project

The mechanisms of respiratory and cardiac dysfunction responsible for the increased risk of sudden unexpected death in epilepsy. (NU21-04-00601)

research and practice. These deaths follow generalized tonic clonic seizures to investigate apnoeas and bradyarrhythmias associated with tonic clonic seizures repeated seizures, as found in rats, also occurs in humans afte...

Clinical neurology

  • 2021 - 2024
    • •
  • 10 808 tis. Kč
    • •
  • 10 808 tis. Kč
    • •
  • MZ
Project

Synthesis and evaluation of neurosteroids as possible antiepileptics (IBS5011007)

New types of compounds, capable of binding to the steroid site of GABA-A receptor supramolecular complex, will be synthesized. Anticonvulsant action of these compounds will be tested against motor seizures induced by pentylenetetrazol in adu...

CC - Organická chemie

  • 2000 - 2004
    • •
  • 4 397 tis. Kč
    • •
  • 2 085 tis. Kč
    • •
  • AV ČR
Project

Vascular and nonvascular nature of ischemia-induced seizures in immature rats (GPP304/11/P386)

which is a frequent cause of seizures in this age group. This pathology can. To understand better the mechanisms of seizure generation, we will inject ET-1 in microdialysate. These data will be correlated with videoEEG monitoring f...

ED - Fyziologie

  • 2011 - 2015
    • •
  • 2 172 tis. Kč
    • •
  • 2 172 tis. Kč
    • •
  • GA ČR
Project

Mechanisms and consequences of brain damage associated with seizure activity in immature rats (GA309/02/1238)

Prolonged seizures in early development can cause brain damage and lead seizures in immature 12-day-old rats by i.c.v. infusion of DL-homocysteic acid associated with seizure activity and to elucidate conditions leading to ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2002 - 2004
    • •
  • 7 582 tis. Kč
    • •
  • 3 072 tis. Kč
    • •
  • GA ČR
Project

Daily evolution of brain connectivity during the pre-ictal period in intracerebral recordings of epileptic patients (8J20FR037)

worldwide, characterized by repeated brain seizures, the neurophysiological mechanisms brain state before seizure. We aim to identify changes in brain connectivity brain areas as the brain is approaching a seizure. Based o...

Neurosciences (including psychophysiology)

  • 2020 - 2022
    • •
  • 151 tis. Kč
    • •
  • 151 tis. Kč
    • •
  • MŠMT
Project

Detection of seizure onset zone in multi-lesional epilepsies using multimodal imaging methods (NU21-04-00254)

worldwide (WHO, 2009). The number of epileptic seizures can be decreased with medication, but in 30% of the cases the seizures are resistant to antiepileptic drugs and surgery for seizures can be identified while the other...

Clinical neurology

  • 2021 - 2024
    • •
  • 11 819 tis. Kč
    • •
  • 11 819 tis. Kč
    • •
  • MZ
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