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Project

Sepsis Risk Evaluation in Children by Gene Polymorphism Study (NR8046)

The aim of this project is to introduce the genetic determination of sepsis in children based on polymorphism studies of certain genes. The results can reveal gene variant combinations predisposing to severe sepsis.......

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 3 411 tis. Kč
    • •
  • 2 963 tis. Kč
    • •
  • MZ
Project

Development of PCR tests for rapid diagnosis of sepsis (FW10010005)

The aim of the project is the development of methods and diagnostic kits for fast and sensitive diagnostics of the most common bacterial pathogens causing sepsis.......

Industrial biotechnology

  • 2024 - 2026
    • •
  • 32 924 tis. Kč
    • •
  • 22 490 tis. Kč
    • •
  • TA ČR
Project

The effect of immunosuppression on immunopathologic alterations in an animal model of sepsis (NS10556)

The aim of the project is to study differences in the course of clinical and laboratory parameters in the immunopathological response to sepsis in a group of experimental animals with and without immunosuppression.......

FJ - Chirurgie včetně transplantologie

  • 2009 - 2011
    • •
  • 5 148 tis. Kč
    • •
  • 5 148 tis. Kč
    • •
  • MZ
Project

Therapeutic potential of mesenchymal stem cells in experimental porcine sepsis. (NV15-32801A)

Sepsis (life-threatening infection) is a major public health problem with wide need to develop innovative and efficacious therapies for sepsis/septic shock. With regard to the complexity of the sepsis, a complex therapy aim...

FP - Ostatní lékařské obory

  • 2015 - 2018
    • •
  • 4 865 tis. Kč
    • •
  • 4 865 tis. Kč
    • •
  • MZ
Project

Biomarkers of endothelial injury diagnostic significance of endothelial microvesicles, soluble proteins and microRNA in neonatal sepsis (NU20-07-00109)

Neonatal sepsis is a leading cause of mortality in children younger than 5 years. Early-onset sepsis has mortality rates up to 30%. Accurate diagnosis presentation of neonatal sepsis is often subtle and nonspecific, and com...

Paediatrics

  • 2020 - 2023
    • •
  • 9 557 tis. Kč
    • •
  • 9 557 tis. Kč
    • •
  • MZ
Project

Continuous renal replacement methods in the treatment of sepsis (NI4972)

Evaluation of increased activation of the cellular immunity as a positive effect of haemofiltration (CRRT) in the treatment of sepsis and MOF. Evaluation of the problem of bio(in) compatibility of HD membranes in relation to lymphocyte activ...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1998 - 2000
    • •
  • 1 138 tis. Kč
    • •
  • 1 066 tis. Kč
    • •
  • MZ
Project

Immodin to influence immunoparalysis, MODS and sepsis course in long term ICU patients (NR7777)

of multiorgan dysfunction syndrome and sepsis in long term ICU patients. Hypothesis of multiorgan dysfunction syndrome and sepsis in long term ICU patients.......

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2004 - 2006
    • •
  • 3 152 tis. Kč
    • •
  • 3 152 tis. Kč
    • •
  • MZ
Project

Role of monocyte metabolism and transcription factor networks in progression of human sepsis. (NV18-06-00529)

of sepsis, but the mechanisms that lead to cellular dysfunction, organ failure and death molecules that are closely correlated with sepsis development and clinical outcomes. We that control monocyte function in human sepsis

Immunology

  • 2018 - 2021
    • •
  • 11 989 tis. Kč
    • •
  • 11 629 tis. Kč
    • •
  • MZ
Project

Genetic risk prediction to sepsis in children (GP301/03/D196)

plays an important role in surviving sepsis. Some of the most important with severe infections, development of sepsis, multiorgan failure and death. The aim predisposing to severe sepsis in children hospitalized at the Uni...

FG - Pediatrie

  • 2003 - 2006
    • •
  • 746 tis. Kč
    • •
  • 746 tis. Kč
    • •
  • GA ČR
Project

The role of autonomic nervous system in sepsis development (GA15-15716S)

Sepsis (life-threatening infection) is a major public health problem with broad in sepsis. There remain a number of questions (optimal modulation of vagus nerve in the sepsis and to define the most efficacious intervention ...

FE - Ostatní obory vnitřního lékařství

  • 2015 - 2019
    • •
  • 7 321 tis. Kč
    • •
  • 7 321 tis. Kč
    • •
  • GA ČR
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