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Serpins from the salivary glands of Lyme disease vector, the tick Ixodes ricinus, and their role in the tick-host-pathogen interaction (GJ16-07117Y)
of host defensive mechanisms. Tick salivary protease inhibitors, serpins, were shown glands of Ixodes ricinus secrete high number of serpins that can protect tick from. ricinus salivary serpins, in order to better understa...
EB - Genetika a molekulární biologie
- 2016 - 2020 •
- 5 616 tis. Kč •
- 5 616 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2016 - 22. 7. 2020
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Anti-hemostatic serpins from the tick Ixodes ricinus and their role in pathogen transmission (GJ19-14704Y)
salivary serpins represent unique group that can be targeted by anti-tick serpin anti-hemostatic activity and the rejection of ticks by the host. Main objective of herein proposed project is to analyze recombinant tick salivary
Biochemistry and molecular biology
- 2019 - 2023 •
- 7 739 tis. Kč •
- 7 739 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2019 - 31. 12. 2023
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Molecular and cellular mechanisms of immunomodulatory activities of tick salivary serpins (GA25-18392S)
Serpins are protease inhibitors, regulating many physiological processes. In humans, they are involved in the pathology of hematological and immune-mediated diseases. Serpins from tick saliva have anti-hemostatic and immunomodulator...
Biochemistry and molecular biology
- 2025 - 2027 •
- 10 000 tis. Kč •
- 10 000 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2025 - 31. 12. 2027
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
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