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3 598 (0,065s) •

Project

Fatty acid- and glucose-induced changes in gene expression of peroxisome proliferator-activated receptor (PPAR) signalling cascade molecules (OC 153)

investigation of effects of major energetic substrates on gene expression of major molecular components of signalling molecules...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2010
    • •
  • 2 910 tis. Kč
    • •
  • 1 895 tis. Kč
    • •
  • MŠMT
Project

Development of new chemical compounds with anti-tumor activities or use in regenerative medicine (FR-TI4/802)

is regulated by a limited set of signaling cascades. Interestingly, the dysregulation of these cascades can ultimately lead to the cellular transformation. The main goal of the project is to identify and characterize m...

CC - Organická chemie

  • 2012 - 2015
    • •
  • 25 398 tis. Kč
    • •
  • 19 971 tis. Kč
    • •
  • MPO
Project

Interaction of bacterial sensor kinase with peptidoglycan subunits and its impact on the cell wall biosynthesis (LH12055)

or abrogated binding ability for the ligand molecules. Consequently, kinase-dependent signalling cascade will be blocked. The collective set of experiments should shed definitive light on bacterial intracellular signal...

EE - Mikrobiologie, virologie

  • 2012 - 2015
    • •
  • 3 244 tis. Kč
    • •
  • 3 152 tis. Kč
    • •
  • MŠMT
Project

Cellular role of MAP kinase signaling cascade in plants through regulation of nucleation and organization of microtubular cytoskeleton. (7AMB13AT013)

to understant how external cues contribute through MAP kinases signaling cascade to changesCell respond to external and internal cues by activation of cellular signalling and phosphatases. This project aims to find the lin...

EB - Genetika a molekulární biologie

  • 2013 - 2014
    • •
  • 163 tis. Kč
    • •
  • 163 tis. Kč
    • •
  • MŠMT
Project

Uncovering the Wnt Destruction complex effects on NOTCH receptor signaling in vertebrates (GA24-10622S)

The cellular ability to communicate through cascades of molecular interactions - signaling pathways - is a defining aspect of multicellular life. Key signaling pathways to the possibility of direct molecular interaction bet...

Developmental biology

  • 2024 - 2026
    • •
  • 6 999 tis. Kč
    • •
  • 6 999 tis. Kč
    • •
  • GA ČR
Project

Molecular cloning and functional characterization of the Wnt signaling pathway components in man (IAA5052905)

Wnt proteins are secreted signaling molecules that regulate diverse developmental processes. The Wnt action is mediated via a signal transducing cascade including multiple components. Geneinactivation of one downst...

EB - Genetika a molekulární biologie

  • 1999 - 2002
    • •
  • 2 936 tis. Kč
    • •
  • 1 676 tis. Kč
    • •
  • AV ČR
Project

Roles of extracellular adenosine in hematopoiesis and innate immunity using Drosophila as a model to study these roles in vivo (KJB501410602)

Extracellular adenosine is a potent signaling molecule with various effects of adenosine in immunomodulation and its relationship with the NF-kB signaling cascade. We of adenosine as a developmental signal...

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 1 925 tis. Kč
    • •
  • 1 925 tis. Kč
    • •
  • AV ČR
Project

The dopamine and prolactin role during tumor progression and immunomodulatory effect of dopaminergic ergot alkaloids. (GA310/98/0347)

The neuroendocrine, and the immune systems contribute to the maintenance of homeostasis, comunicating through signal molecules and related receptors. According to our regulatory neurotransmitter ( dopamine ) in tumor growth and ...

FD - Onkologie a hematologie

  • 1998 - 2000
    • •
  • 2 607 tis. Kč
    • •
  • 2 489 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanism of apoptosis induced by alfa-tocopheryl succinate in cancer cells. (KJB500970904)

by ROS-mediated apoptotic cell death. However, little is known about signaling cascades and molecules responsible for this pro-apoptotic effect of alfa-TOS in cancer are involved in this process) and signaling pat...

EB - Genetika a molekulární biologie

  • 2009 - 2010
    • •
  • 971 tis. Kč
    • •
  • 971 tis. Kč
    • •
  • AV ČR
Project

Structure and function of sensor domain of proteinkinase StkP and its relationship to cellular processes (GAP207/12/1568)

affinity to the ligand molecules. Consequently, StkP-dependent signalling cascade will be blocked on the input. The effect of interruption of signal transduction on cellularPknB-like protein kinases make up a dist...

CE - Biochemie

  • 2012 - 2015
    • •
  • 4 374 tis. Kč
    • •
  • 4 374 tis. Kč
    • •
  • GA ČR
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