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2 811 (0,194s) •

Project

The role of the JAK/STAT signalling pathway in cellular senescence (GA204/08/1418)

Cellular senescence is proposed to be a tumorigenesis barrier to slow or inhibit the progression of proneoplastic lesions to neoplasia. In our recent work we found persistent activation of JAK/STAT signaling pathway during drug-indu...

CE - Biochemie

  • 2008 - 2012
    • •
  • 6 643 tis. Kč
    • •
  • 6 643 tis. Kč
    • •
  • GA ČR
Project

Establishing the signaling pathway associated with secondary injury, reactive oxygen species and inflammation in spinal cord injury and during its repair. (LTAUSA17120)

To study signalling pathways activated during spinal cord injury, particularly mTOR pathway in cells and in spinal cord tissue. To study inhibition of mTOR pathway using blocators of mTORC1 or mTORC2 complex. To st...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2020
    • •
  • 7 673 tis. Kč
    • •
  • 7 673 tis. Kč
    • •
  • MŠMT
Project

Molecular mechanisms of non-canonical Wnt signaling in leukemia (GAP301/11/0747)

Wnts, a family of glycoproteins, signal through a variety of signaling pathways of non-canonical Wnt signalling (Wnt/PCP pathway) in context of B-Cell Chronic LymphocyticLeukaemia (CLL). Functional studies...

FD - Onkologie a hematologie

  • 2011 - 2014
    • •
  • 5 360 tis. Kč
    • •
  • 5 360 tis. Kč
    • •
  • GA ČR
Project

Disentangling the Notch signalling pathway in Myxozoa (GJ19-25536Y)

Notch signalling is among the oldest known signalling pathways of metazoans. The fundamental role of this pathway lies in affecting a multitude of developmental mechanisms. To extend the knowledge on Notch sign...

Developmental biology

  • 2019 - 2023
    • •
  • 5 178 tis. Kč
    • •
  • 5 178 tis. Kč
    • •
  • GA ČR
Project

Alterations in translational control through signal transduction pathways in v-Src-transformed cells as a model target for cancer therapy (GA301/04/0550)

distinct signal transduction pathways that control mRNA translation are activated: the mTOR/S6K pathway that is controlled by the rapamycin-sensitive mechanisms and the signalling pathway of phospoinosito...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 2 648 tis. Kč
    • •
  • 2 648 tis. Kč
    • •
  • GA ČR
Project

Novel pathways of FGFR3 signaling in achondroplasia (GA301/09/0587)

. Specific inhibition of known FGFR3 signaling pathways in cartilage rescues the FGFR3 effects onlypartially, strongly suggesting the existence of yet unknown pathways. Our proposal aims on discovery of such pathways

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 2 850 tis. Kč
    • •
  • 2 850 tis. Kč
    • •
  • GA ČR
Project

A continuum model for tumour suppressor mechanism orchestrated by the Hippo signalling pathway. (GP14-21095P)

Hippo signalling pathway represents an universal organ-size control and tumour-suppressor mechanism constrained between all metazoans. Hippo pathway was recently mechanisms responsible for the Hippo signalling acti...

EB - Genetika a molekulární biologie

  • 2014 - 2016
    • •
  • 2 448 tis. Kč
    • •
  • 2 448 tis. Kč
    • •
  • GA ČR
Project

The role of feedback circuits and the mechanisms of acoustical signal processing in the central auditory system (GA309/01/1063)

Feedback circuits play an important role in the processing of acoustical signals in the central auditory system. The aim of the proposed project is to investigate the role of corticothalamic and corticotectal auditory pathways as we...

ED - Fyziologie

  • 2001 - 2003
    • •
  • 7 651 tis. Kč
    • •
  • 4 977 tis. Kč
    • •
  • GA ČR
Project

Control of mTOR and MAPK pathways by Src tyrosine kinase activity - implication for cancer therapy by protein kinase inhibitors (NT11231)

proteins in the mTOR signalling pathway. It indicates that, besides rapamycin and its in the deregulated signalling of two important pathways, the mTOR pathway and the MAPK cascade against tumors with dif...

FD - Onkologie a hematologie

  • 2010 - 2013
    • •
  • 3 723 tis. Kč
    • •
  • 3 723 tis. Kč
    • •
  • MZ
Project

The impact of cytokinin-ethylene signaling crosstalk to Arabidopsis growth (GJ19-23108Y)

signaling pathways. Our preliminary data suggest that not only cytokinins but also (CTR1/EIN2/EIN3) ethylene signaling pathways in the root growth and development. phosphorelay (MSP) pathway. However, bot...

Plant sciences, botany

  • 2019 - 2022
    • •
  • 5 966 tis. Kč
    • •
  • 5 966 tis. Kč
    • •
  • GA ČR
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