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29 (0,077s) •

Project

Unknown and unexplored molecules and biological activities of silymarin (GA25-15246S)

" fraction of silymarin, an extract from the fruits of milk thistle (Silybum marianum L. Gaertn). Although many scientific groups are studying silymarin, no one has looked in silymarin. Since silymarin, including t...

Organic chemistry

  • 2025 - 2028
    • •
  • 11 276 tis. Kč
    • •
  • 10 520 tis. Kč
    • •
  • GA ČR
Project

Preparation of glycosylated silymarin for better solubility and targetting. (OK 184)

FR - Farmakologie a lékárnická chemie

  • 1996 - 1997
    • •
  • 667 tis. Kč
    • •
  • 463 tis. Kč
    • •
  • MŠMT
Project

The role of optically pure flavonolignans in cardiovascular effects of silymarin (GA18-00121S)

Biological activity of silymarin has traditionally been ascribed to silybin-dehydroflavonolignans. Moreover, the effect of silymarin constituents on the cardiovascular system to silymarin complex. The aim of this project is...

Pharmacology and pharmacy

  • 2018 - 2022
    • •
  • 6 459 tis. Kč
    • •
  • 6 459 tis. Kč
    • •
  • GA ČR
Project

Targeted chemotherapy towards diseases caused by endoparasites (LD15081)

The aims of the project are to investigate the utilization of some silymarin discovered antiparasitic activity of some of the silymarin flavonolignan derivatives and to try to enhance this activity by further derivatization. Main

CC - Organická chemie

  • 2015 - 2017
    • •
  • 1 322 tis. Kč
    • •
  • 1 322 tis. Kč
    • •
  • MŠMT
Project

Dehydro-derivatives of the silymarin flavonolignans metabolism and biological activity (GA15-03037S)

Silymarin, a mixture of flavonolignans extracted from the seeds of Silybum is traditionally ascribed to the main constituent, silybin. However, the mode of silymarin of biotransformations on silymarin bioactivity remain not...

FR - Farmakologie a lékárnická chemie

  • 2015 - 2017
    • •
  • 8 052 tis. Kč
    • •
  • 8 052 tis. Kč
    • •
  • GA ČR
Project

Inter-individual variability in the metabolism of silymarin flavonolignans in humans (GA18-00132S)

Silymarin, extract from the fruits of milk thistle (Silybum marianum), is used activity. The main silymarin constituents, i.e. silybin and related flavonolignans variability in silymarin metabolism have been performed to da...

Toxicology

  • 2018 - 2020
    • •
  • 8 012 tis. Kč
    • •
  • 7 587 tis. Kč
    • •
  • GA ČR
Project

Modulation of human skin cell responses to UVA radiation by silymarin components (GA15-10897S)

Silymarin, a standardized extract from the seeds of Silybum marianum, and its radiation (315-400 nm) has not been studied yet. Although silymarin and silybin are used been ignored. Further, transdermal delivery of silymarin...

DN - Vliv životního prostředí na zdraví

  • 2015 - 2017
    • •
  • 5 469 tis. Kč
    • •
  • 5 469 tis. Kč
    • •
  • GA ČR
Project

Effective production of Silymarin (EG19_262/0020147)

The aim of the project is to create a new production process of mechanical processing of the input substance, which will allow an overall increase in the content of silymarinated complex in the pre-extraction raw material to 6 - 8% with the ...

Pharmacology and pharmacy

  • 2020 - 2023
    • •
  • 8 260 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • MPO
Project

Gastrointestinal absorption and metabolism of drugs from the group of plant-derived phenylpropanoids (LTC19008)

metabolites of stilbenes and silymarin in human gastrointestinal tract using in vitro. Determination of catabolism of major dietary stilbenes and silymarin components. 3. Absorption of dietary stilbenes and silymarin in Ca...

Biochemistry and molecular biology

  • 2019 - 2021
    • •
  • 4 434 tis. Kč
    • •
  • 4 434 tis. Kč
    • •
  • MŠMT
Project

Combined hepatoprotective formulation based on silymarine and natural antioxidants. (PP-Z1/13)

The outcome will be a new preparation based on silymarin and/or its derivates in combination with natural antioxidants. It will be an original formula (subject to patent) and is to be sold without prescription for prevention purposes. The pr...

FR - Farmakologie a lékárnická chemie

  • 1996 - 2000
    • •
  • 9 747 tis. Kč
    • •
  • 6 230 tis. Kč
    • •
  • MPO
  • 1 - 10 out of 29